2-Chloromethyl-3-Methyl-4-(3-Methoxypropoxy) Pyridine HCl

2-Chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine hydrochloride is an organic compound. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry.
In the research and development of Gain Medicine, the synthesis of many active pharmaceutical ingredients relies on this compound to participate in specific reactions to build key chemical structures. With its unique chemical structure and reactivity, it can cleverly interact with other reagents to build complex and biologically active molecular structures.
In the field of organic synthesis, it is also an important building block. Chemists design and execute various organic reactions with their special functional groups to realize the construction of complex organic molecules, providing the necessary material basis for the research and development of new materials and the total synthesis of natural products.
For example, in the synthesis path of a new type of antibacterial drug, 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine hydrochloride acts as a precursor. Through a series of reaction steps, key pyridine structural fragments are successfully introduced, which in turn endows the target drug with antibacterial activity.
In the exploration of materials science, using this compound as the starting material, the polymer material with special photoelectric properties is constructed by organic reaction, which opens up the possibility for the research and development of new photoelectric materials.

To prepare 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine hydrochloride, the common synthesis method is as follows.
First, you can take a suitable pyridine derivative as the starting material. In a suitable reaction vessel, add this pyridine derivative, and then dissolve it in a specific organic solvent, such as dichloromethane, which can provide a homogeneous environment for the reaction. Then, under low temperature and stirring conditions, slowly add chloromethylating reagents, such as chloromethyl methyl ether, and add an appropriate amount of base, such as triethylamine, to promote the reaction. The function of the base is to neutralize the acid generated by the reaction and move the reaction in a positive direction. At this stage, chloromethyl groups are selectively introduced into specific positions of the pyridine ring to form pyridine intermediates containing chloromethyl groups.
Second, for the above-mentioned intermediates, an etherification reaction is performed. The intermediate is placed in another reaction system, and 3-methoxypropanol is added to catalyze with a specific catalyst, such as p-toluenesulfonic acid. The reaction mixture is heated to maintain the temperature in a suitable range, such as 80-100 ° C. Under this condition, the alcohol hydroxyl group undergoes a nucleophilic substitution reaction with a specific position on the pyridine ring, thereby connecting the 3-methoxypropoxy group to obtain the target product precursor.
Third, the precursor product is further processed and converted into the hydrochloride form. Add an appropriate amount of hydrogen chloride gas or hydrochloric acid solution to the product, control the reaction conditions, and fully react with hydrogen chloride to obtain 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine hydrochloride.
During the entire synthesis process, close attention should be paid to the control of reaction conditions, such as temperature, reaction time, and reagent dosage, which all have an important impact on the yield and purity of the product. After each step of the reaction, suitable separation and purification methods, such as column chromatography and recrystallization, are also required to ensure the purity of the intermediate and final product, in order to achieve the ideal synthesis effect.

2-Chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine hydrochloride, this substance is an organic compound with specific physical and chemical properties.
Looking at its physical properties, under room temperature, or in solid form, in view of its structure containing polar groups, such as methoxy, pyridine ring, etc., it may have a certain solubility in polar solvents. However, due to the large organic group in the molecule, its solubility in non-polar solvents may be limited. Its melting point, boiling point and other parameters will be determined by intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. Among them, hydrogen bonds can be formed between polar groups, resulting in increased intermolecular force, melting point, boiling point or higher.
As for chemical properties, chloromethyl groups in this compound are active and prone to nucleophilic substitution. Nucleophilic reagents can attack the carbon atoms of chloromethyl groups, and chlorine atoms leave to form new compounds. If reacted with alcohol nucleophilic reagents, ether products can be formed. Pyridine rings are also chemically active, and their nitrogen atoms have lone pairs of electrons, which can be used as nucleophilic check points to participate in the reaction. For example, nucleophilic substitution occurs with halogenated hydrocarbons, and new groups are introduced on the nitrogen atoms of pyridine rings. In addition, the form of hydrochloric acid makes it acidic, and under appropriate conditions, it can neutralize with bases and convert into free base forms.
The physicochemical properties of this compound are determined by its molecular structure, and they have shown important uses in organic synthesis, medicinal chemistry, and other fields due to these properties.

There are 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine hydrochloride salts in the market today, but its price range is difficult to determine. According to Guan Fu's "Tiangong Kaiwu", the price of things in the past often varied according to time, place, quality and supply and demand. This compound, in the field of chemical industry, has a specific purpose, and its price must also be affected by various factors.
With common sense, if the preparation of this compound is difficult, the raw materials are rare, the process is complicated, and the market demand is strong, the price will be high. On the contrary, if the preparation is easy, the raw materials are sufficient, the supply exceeds the demand, and the price may be slightly cheaper. However, the current market conditions are unpredictable, and it is difficult to determine its exact value without detailed business conditions.
Or you can check the traces of its price at the place where the chemical materials are traded and various online chemical platforms to get a more accurate range. And different suppliers, batch sizes, and prices are also different. Generally speaking, if you want to know its price, you should search the market situation widely and compare it with everyone's reports. However, the exact price range is difficult to determine based on speculation.

2-Chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine hydrochloride, this medicine is a delicate chemical compound. Its storage conditions are very critical, related to the stability and efficacy of the drug.
According to the ancient method, it is necessary to choose a good place for storage, and this medicine is no exception. It should be placed in a cool place, because high temperature can easily cause structural variation of the medicine, and the efficacy of the medicine will be damaged. In the summer heat, do not expose this medicine to the hot sun, or close to warm sources, such as fires, heaters, etc.
Furthermore, keep the place of storage dry. Moisture is the enemy of medicine, which can cause deliquescence and deterioration. If placed in a humid place, the medicinal material is prone to mildew and rot. The medicine will also invade due to moisture, chemically react, and lose its original properties.
And it needs to be sealed and stored. Oxygen, carbon dioxide, etc. in the air can react with the medicine. Open to the air, the medicine is easily oxidized or combined with carbon dioxide, and the efficacy of the medicine is greatly reduced.
As for the use, also be cautious. The utensils used must be clean and dry to prevent impurities from mixing in and damaging its quality.
In this way, follow the tips of cool, dry, and sealed, and store properly to maintain the excellent properties of 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine hydrochloride for a long time for medicinal purposes.