2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDINE-4-CARBONITRILE

2-Chloro-6- (trifluoromethyl) pyridine-4-formonitrile has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Complex compound structures with specific pharmacological activities can be constructed through a series of chemical reactions. For example, when developing some new antibacterial drugs, it can participate in the synthesis of pyridine ring derivatives. By modifying the substituents on the pyridine ring, the physicochemical properties and biological activities of the drug molecules can be changed to improve the antibacterial effect and selectivity.
In the field of pesticide creation, 2-chloro-6- (trifluoromethyl) pyridine-4-formonitrile also plays an important role. It can be used as a starting material for the synthesis of high-efficiency, low-toxicity and environmentally friendly pesticides. Through chemical transformation, compounds with insecticidal, bactericidal or herbicidal activities are derived. For example, by reacting with other reagents containing functional groups such as nitrogen and oxygen, pesticide molecules with specific structures are generated. With its unique chemical structure, it enhances the specificity and affinity for target organisms, realizes precise killing of pests, and reduces the impact on non-target organisms.
In addition, in the field of materials science, it may be used to prepare functional materials. Due to the fluorine atoms in the molecule, the material is endowed with unique physical and chemical properties, such as improving the corrosion resistance, thermal stability and low surface energy of the material. It can participate in the synthesis of new fluoropolymer materials for special coatings, electronic materials, etc., to meet the specific needs of material properties in different fields.

2-Chloro-6- (trifluoromethyl) pyridine-4-formonitrile, this is an organic compound. Its physical properties are quite critical and it has many applications in various fields of chemistry.
Looking at its appearance, it is often in the form of white to light yellow crystalline powder. This state is easy to identify and process, and it is conducive to accurate access in many chemical operations.
When talking about the melting point, it is about [X] ° C. The melting point is an important characteristic of the substance and can be used to identify the purity. When the purity is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point decreases and the range becomes wider.
In terms of boiling point, it is about [X] ° C. The boiling point reflects the temperature at which a substance changes from a liquid state to a gaseous state. In the separation process such as distillation, the mixture can be separated according to the difference in boiling point.
The solubility of this compound cannot be ignored. In organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), this compound exhibits good solubility. This makes it possible to choose these solvents to build a reaction system in organic synthesis, which promotes the smooth progress of the reaction. However, in water, its solubility is poor. This property is instructive in the separation and purification of products. The insolubility of water and organic solvents can be used to achieve the purpose of separation by extraction and other operations.
The density is about [X] g/cm ³. Density data is very important in material accounting and design of chemical equipment, and is related to the calculation of reaction vessel size, material feeding volume, etc.
In addition, the vapor pressure of this compound is relatively low. The vapor pressure reflects the tendency of material volatilization. Low vapor pressure means slow volatilization at room temperature. During storage and use, less volatilization loss and higher stability.
The above physical properties are of important guiding value for the synthesis, storage, transportation and application of 2-chloro-6- (trifluoromethyl) pyridine-4-formonitrile. Knowing these properties allows chemists to use this compound rationally in different scenarios to achieve the desired chemical purpose.

The synthesis method of 2-chloro-6- (trifluoromethyl) pyridine-4-formonitrile can be obtained from several ways. One method is to take pyridine compounds as the starting material and react through various steps such as halogenation, cyanation, and trifluoromethylation. First, take a suitable pyridine substrate, and under suitable conditions, use a chlorinated reagent to perform halogenation to make the chlorine atom occupy the designated position in the pyridine ring. In this step, appropriate reaction conditions, such as temperature, solvent, catalyst, etc., are selected to increase the selectivity and yield of the reaction.
Then, the halogenated product is cyanidated. The cyanidation method often uses cyanide reagents, such as potassium cyanide, sodium cyanide, etc., to react with halides with the help of phase transfer catalysts to replace halogen atoms with cyanyl groups to obtain cyanide-containing pyridine intermediates. In this step, attention should be paid to the toxicity of cyanide, the operation should be in a well-ventilated place, and the temperature and reaction process should be carefully controlled. After
, trifluoromethylation is performed. Trifluoromethylation reagents are commonly used, such as trifluoromethyl halogenation reagents or reagents with trifluoromethylation function. In a specific reaction system, trifluoromethyl is connected to the corresponding check point of the pyridine ring, and then the target product 2-chloro-6- (trifluoromethyl) pyridine-4-formonitrile is obtained. This step also requires fine-tuning the reaction conditions to achieve satisfactory results.
Another synthesis method, or you can start from other nitrogen-containing heterocyclic compounds and gradually construct the target molecular structure through multi-step functional group transformation. The choice of starting materials and the sequence of reaction steps need to be carefully determined according to the specific reaction mechanism and experimental conditions. In each step of the reaction, the product needs to be separated and purified to ensure the purity of the reaction and the smooth subsequent reaction. Successful synthesis of 2-chloro-6- (trifluoromethyl) pyridine-4-formonitrile.

I look at your question, and I am inquiring about the market price of 2-chloro-6- (trifluoromethyl) pyridine-4-formonitrile. However, the price of this chemical often varies due to factors such as time, place, supply and demand, and it is difficult to directly determine.
Looking at the market conditions in the past, the price of such fine chemicals often depends on their purity, output and demand. If the purity is extremely high, it is suitable for high-end scientific research or special industrial processes, and the price is high. For example, in the field of fine chemical research and development, extremely high purity is required to ensure experimental accuracy, so I am willing to pay a high price.
Yield is also key. If the output is scarce, or the raw materials are difficult to obtain, the preparation process is complicated, and the production cost is high, the price in the market will also be high. On the contrary, if the output is sufficient, the scale effect is obvious, the cost can be reduced, and the price may become easier.
Furthermore, the ups and downs of market demand also affect its price. If the demand for 2-chloro-6- (trifluoromethyl) pyridine-4-formonitrile in a certain industry increases sharply, such as the pharmacy developing new drugs requires a large amount of this product, the supply is in short supply, and the price will rise; if the demand is weak and the supply exceeds the demand, the price may decline.
And in different regions, due to different transportation costs, tax policies, and the degree of development of the local chemical industry, prices vary. In places with developed chemical industries, raw materials are easy to obtain, production is convenient, or the price is slightly lower; while in remote places with weak chemical bases, the price may be higher due to the superposition of transportation and other costs.
Therefore, if you want to know the exact market price, you should consult chemical raw material suppliers, chemical trading platforms, or pay attention to chemical industry information to get real-time and accurate price information.

2-Chloro-6- (trifluoromethyl) pyridine-4-formonitrile is a commonly used chemical raw material in organic synthesis. During storage and transportation, many things must be paid attention to:
First, the storage environment is the most critical. This chemical should be stored in a cool, dry and well-ventilated place. High temperature and humidity can easily cause its deterioration. Be sure to keep away from fires and heat sources. When heated, the stability of the chemical may be damaged or dangerous chemical reactions may occur. Warehouse temperature should be controlled within an appropriate range to prevent temperature fluctuations from adversely affecting it.
Second, it needs to be isolated from contraindications. 2-Chloro-6- (trifluoromethyl) pyridine-4-formonitrile shall not be mixed with strong oxidants, strong acids, strong bases and other co-storage. Such substances come into contact with it, or trigger violent chemical reactions, resulting in serious consequences such as combustion and explosion. When storing, it should be strictly divided, classified and stored in different warehouses according to the nature of the chemical.
Third, the packaging must be tight. Before transportation, ensure that the packaging is intact and the packaging materials used must adapt to its characteristics. If the packaging is not strict, it may cause leakage during transportation, which will not only pollute the environment, but also endanger the safety of transporters and surrounding facilities.
Fourth, the transportation process should be cautious. Select transportation enterprises and personnel with professional qualifications, and the transportation vehicles should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. During driving, avoid violent operations such as sudden braking and sharp turns to prevent damage to the packaging.
Fifth, do a good job of marking and recording. Storage containers and transportation vehicles should be clearly marked with chemical names, hazardous characteristics, emergency treatment methods and other information. At the same time, establish detailed warehousing records to trace the flow and use.
Only by strictly observing the above precautions can we ensure the safety of 2-chloro-6- (trifluoromethyl) pyridine-4-formonitrile during storage and transportation and prevent accidents.