2-chloro-6-methoxy-3-nitropyridine

2-Chloro-6-methoxy-3-nitropyridine is an important chemical substance in the field of organic synthesis. It has a wide range of main uses and is often a key intermediate in the synthesis of many drugs in medicinal chemistry. Due to the unique structure of the pyridine ring, this compound is endowed with specific reactive and biological activities. It can be introduced into other functional groups through a series of chemical reactions to construct complex molecular structures with specific pharmacological activities, which can be used to develop new drugs and treat various diseases.
In the field of pesticide chemistry, 2-chloro-6-methoxy-3-nitropyridine also has important applications. It can be used as a raw material to chemically synthesize pesticides, fungicides and other pesticide products. By modifying the substituents on the pyridine ring, the activity, selectivity and environmental compatibility of pesticides can be adjusted, the control effect of pesticides on specific pests or pathogens can be improved, and the adverse effects on the environment can be reduced.
In addition, in the field of materials science, this compound may also have potential uses. It can be introduced into the structure of polymer materials through special reactions, giving the material specific properties, such as improving the stability, conductivity or optical properties of the material, providing a new way for the research and development of new functional materials.
In conclusion, 2-chloro-6-methoxy-3-nitropyridine has shown important application value in many fields such as medicine, pesticides and materials science due to its unique chemical structure and reactivity, providing a key foundation for innovation and development in related fields.

There are several ways to prepare 2-chloro-6-methoxy-3-nitropyridine.
First, 2-hydroxy-6-methoxy pyridine can be started. React with a suitable chlorination reagent, such as phosphorus trichloride, to convert the hydroxyl group into a chlorine atom to obtain 2-chloro-6-methoxy pyridine. After that, nitrifying reagents, such as concentrated nitric acid and concentrated sulfuric acid, are used to nitrate them, and nitro groups are introduced at suitable positions in the pyridine ring to obtain 2-chloro-6-methoxy-3-nitropyridine. In this path, in the first step of chlorination, attention should be paid to the reaction temperature and reagent dosage to ensure that the reaction proceeds smoothly and there are few side reactions; in the second step of nitrification, the conditions should also be strictly controlled. Due to the harsh nitrification conditions of the pyridine ring, improper conditions can easily lead to the formation of polynitrification products.
Second, you can start from 2-chloro-6-methylpyridine. The methyl group is first oxidized to a carboxyl group, and the commonly used oxidants such as potassium permanganate. After obtaining 2-chloro-6-pyridinecarboxylic acid, the esterification reaction is carried out, and the reaction with methanol under the catalysis of sulfuric acid is carried out to generate 2-chloro-6-methoxy methyl pyridinecarboxylate. Next, nitrification is carried out with a nitrifying agent to obtain 2-chloro-3-nitro-6-methoxy methyl pyridinecarboxylate. Finally, the ester group is removed by hydrolysis reaction to obtain the target product. This route has a little more steps, and each step requires fine operation. Oxidation reaction should control the degree of oxidation to avoid excessive oxidation; esterification reaction should pay attention to the reversibility of the reaction to improve the yield; nitrification reaction should pay attention to the localization selectivity; hydrolysis reaction should choose appropriate conditions to ensure the purity of the product.
Third, 2-chloro-3-nitropyridine can be used as raw material to react with sodium methoxide to achieve methoxylation, thereby preparing 2-chloro-6-methoxy-3-nitropyridine. This method is relatively direct, but the acquisition of 2-chloro-3-nitropyridine raw material may be difficult. And in the methoxylation reaction, the amount of sodium methoxide and the reaction temperature and other conditions have a great impact on the reaction results, and need to be carefully regulated.
Where this number method has its own advantages and disadvantages, the actual synthesis, when the availability of raw materials, the ease of control of reaction conditions and product purity requirements and other factors, careful choice.

2-Chloro-6-methoxy-3-nitropyridine is one of the organic compounds. Its physical properties are quite important, and it is of great significance in chemical research and related applications.
Looking at its appearance, under room temperature and pressure, it is mostly in the shape of a solid state, and has a specific crystalline form, with a regular and orderly crystal form. The color of this compound is usually light yellow to yellow, with bright color and easy to distinguish.
When it comes to melting point, the melting point of 2-chloro-6-methoxy-3-nitropyridine is within a certain range, which is crucial for the identification and purification of this substance. The purity can be determined by accurately measuring the melting point.
The boiling point is also one of its important physical properties. Under specific pressure conditions, when the boiling point is reached, the compound changes from liquid to gaseous state. This boiling point data is of guiding significance for the separation, purification and control of reaction conditions.
In terms of solubility, among common organic solvents, 2-chloro-6-methoxy-3-nitropyridine exhibits different degrees of solubility. In some polar organic solvents, such as ethanol and acetone, it has a certain solubility, while in non-polar solvents such as n-hexane, the solubility is relatively weak. This difference in solubility provides a basis for the solvent selection and separation process of chemical reactions.
In addition, the density of the compound is also an inherent physical property. Although the numerical value or the measurement conditions are slightly different, it has a specific density value under the standard conditions, which is helpful for the quantitative analysis and related calculations of the substance.
The physical properties of 2-chloro-6-methoxy-3-nitropyridine, such as appearance, melting point, boiling point, solubility and density, are related and affect each other, and together constitute its unique physical properties. It plays an important role in the research and practical application fields of organic chemistry.

2-Chloro-6-methoxy-3-nitropyridine is one of the organic compounds. Its chemical properties are of great interest and are described in detail by you.
First of all, its substitution reaction. Due to the presence of chlorine atoms in the molecule, it is quite active and can be replaced by many nucleophiles under appropriate conditions. In case of alcohol nucleophiles, under the catalysis of bases, chlorine atoms may be replaced by alkoxy groups to form corresponding ether derivatives. This reaction is of great value in the construction of new compound structures in organic synthesis.
Re-discussion of the properties of its nitro groups. Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the pyridine ring, which increases the difficulty of electrophilic substitution reaction on the ring. However, at the same time, it enhances the acidity of the hydrogen atoms in the neighboring and para-position of the ring. When encountering a strong base, the hydrogen atom may leave, generate corresponding negative ions, and then participate in various nucleophilic reactions.
And because of the existence of methoxy group, methoxy group is the power supply group, which also affects the electron cloud distribution of the pyridine ring. It can increase the electron cloud density of the carbon atoms in the pyridine ring connected to it, which can alleviate the electron cloud density reduction effect caused by nitro to a certain extent. The comprehensive effect of this electronic effect affects the overall reactivity and selectivity of the compound.
In the reduction reaction, the nitro group can be reduced to an amino group, which can be converted into an amino-containing pyridine derivative by appropriate reducing agent treatment, such as the combination of metal and acid, or under the condition of catalytic hydrogenation. Such amino derivatives are often important intermediates in the fields of drug synthesis, dye preparation, etc., and can be further derived to construct more complex molecular structures.
In short, 2-chloro-6-methoxy-3-nitropyridine has rich and diverse chemical properties, and has an important position and broad application prospects in organic synthesis and related fields. With its unique structure and properties, many novel and practical compounds can be created.

I don't know the price range of 2-chloro-6-methoxy-3-nitropyridine in the market. The price of this compound often varies due to many factors.
First, manufacturers vary, and factories have different pricing due to different technologies and cost controls. Large factories have a scale effect, and the cost may be low, and the price may also be competitive; if small factories do not have unique advantages, the price may be high.
Second, purity has a great impact. High purity is often used in high-end scientific research, pharmaceuticals and other fields, and the preparation is difficult, the cost is high, and the price is high; low purity is used in general industry, and the price is relatively low.
Third, the market supply and demand relationship is the key. If the demand is strong and the supply is limited, the price will rise; if the supply exceeds the demand, the manufacturer may reduce the price.
Fourth, the purchase volume also plays a role. Bulk procurement, due to saving packaging, transportation and other costs, the unit price is often lower than a small purchase.
Because I do not know the current specific market conditions, it is difficult to determine the price range. For details, please consult chemical product suppliers, chemical trading platforms, or check industry reports, so that you can get more accurate price information.