2 Chloro 5 Nitro 4 Methylpyridine
pyridine pyrrole pyrazine piperidine piperazine

2-Chloro-5-nitro-4-methylpyridine

    Specifications

    HS Code

    812462

    Chemical Formula C6H5ClN2O2
    Molar Mass 172.57 g/mol
    Appearance Solid (predicted from similar compounds)
    Solubility In Water Insoluble (due to non - polar pyridine ring and hydrophobic groups)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform (typical for aromatic heterocyclic compounds)

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    General Information
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    Frequently Asked Questions

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    What are the physical properties of 2-chloro-5-nitro-4-methylpyridine?
    2-%-5-amino-4-methylpyridine is a characteristic compound. Its physical properties are worth exploring.
    First, its external appearance, often in a liquid color to light color, under normal conditions, the ground phase is uniform, and it has a certain fluidity, which can be easily reversed, just like a clear stream.

    and melting, the melting phase of this compound is low, and it is mostly shown as liquid in normal environments. The boiling effect is changed according to the surrounding environmental forces. Generally speaking, under high temperature, its boiling effect can be reduced to a certain degree. This property makes it necessary to follow a reasonable process for operations such as boiling difference.
    In terms of solubility, 2-%-5-amino-4-methylpyridine exhibits good solubility in multi-soluble solutions, such as ethanol, ether, etc., which can be mutually soluble to form a uniform solution. However, its solubility in water is limited, and it can dissolve a small amount. This property can be used as an important basis for the dissolution of the compound in chemical synthesis and separation.
    Furthermore, this compound has a certain degree of solubility. In an open environment, it is slow to disperse and emits a special smell. This smell is not pungent and also distinguishable. And because of its durability, during the use of storage, it is necessary to pay attention to dense storage to prevent it from spreading, affecting the use effect and even causing safety problems.
    The density also has a specific value, which is different from that of water. This density characteristic can be used as an important judgment in operations such as liquid-liquid separation, and it can be used to help people effectively divide different substances.
    Therefore, there are many physical reasons for 2-%-5-amino-4-methylpyridine, and each aspect is important for its use in chemical synthesis, storage, and separation. It needs to be grasped in order to make good use of it.
    What are the chemical properties of 2-chloro-5-nitro-4-methylpyridine?
    2-% N-5-amino-4-methylpyridine is a special chemical compound, which has a general specialization.
    In this compound, the atomic activity is normal, and the atomic activity is often chemical. In the reaction, the atom is easy to lose the atom to form the atom, or take the atom to form the atom. In 2-% N-5-amino-4-methylpyridine, the atom can interact with other functionalities, such as amino, methyl, and pyridine carbon atoms to form weak interactions, which affect the physical and chemical properties of the compound.
    Furthermore, the 5-amino function is also an important active site of this compound. Amino groups have solitary properties and can neutralize and react to acids to form amines. In the synthesis of amines, aminos can be nucleated and substituted like aminos, such as aminos, to form new nitrogen-containing aminos. And aminos can be formed by the action of acetylated reactants, aminos or acid anhydrides to form aminos. These reactants are used in the synthesis of compounds and the field of materials.
    4-methylyl groups are stable, but they also affect the properties of compounds. The supply of methyl groups can change the density of pyridine clouds and affect the reactivity of pyridine. Pyridine is intrinsically aromatic and has a special distribution of its pi sub-clouds, so that 2-% 5-amino-4-methylpyridine can provide unique antibodies to aromatic compounds, such as antibodies. Due to the localization effect of amino groups, antibodies are often first generated at specific locations of pyridine, and this property is important for the synthesis of derivatives with specific antibodies.
    Of course, the chemical properties of 2-% 5-amino-4-methylpyridine are rich, and the interaction between amino groups, methyl groups, and pyridine antibodies makes them useful in various fields such as synthesis and chemical research.
    What are the common synthesis methods of 2-chloro-5-nitro-4-methylpyridine?
    To prepare 2-bromo-5-amino-4-methylpyridine, the common synthesis methods are as follows:
    First, 4-methylpyridine is used as the starting material. First, 4-methylpyridine is brominated. Suitable brominating reagents can be selected, such as liquid bromine. Under the action of catalysts, at appropriate temperatures and reaction conditions, bromine atoms are substituted for hydrogen atoms at specific positions on the pyridine ring to form bromine-containing 4-methylpyridine derivatives. In this step, attention should be paid to the selectivity of the reaction, and the main substitution of bromine atoms should be made to the desired position. Then, through an appropriate nitration reaction, nitro groups are introduced, and the positioning of nitro groups is affected by the existing substituents on the pyridine ring. Then the nitro group is reduced to an amino group. Commonly used reducing agents include iron and hydrochloric acid. After this step, the target product 2-bromo-5-amino-4-methylpyridine can be obtained.
    Second, pyridine derivatives can also be used as starting materials. Methyl groups are introduced first, which can be achieved under suitable reaction conditions by suitable alkylation reagents. After that, bromination is carried out, and the reaction conditions are controlled to ensure the substitution position of bromine atoms. Finally, amino groups are introduced by specific methods, or by reacting with pyridine derivatives with reagents containing amino groups, and the target products are synthesized through multi-step conversion.
    Third, starting from other simpler raw materials, the pyridine ring is constructed through multi-step reaction, and bromine, amino group and methyl group are gradually introduced. For example, using small molecule compounds containing nitrogen, carbon and bromine, according to the principle of organic synthesis, the pyridine ring is formed by cyclization reaction. During the cyclization process or subsequent reactions, the corresponding substituents are precisely introduced at the desired position, and the corresponding substituents are optimized and purified through a series of reactions, and finally 2-bromo-5-amino-4-methylpyridine is obtained. Each step of the reaction requires fine regulation of factors such as reaction conditions, reagent dosage, and reaction time to improve the yield and selectivity of the reaction and strive to efficiently synthesize the target product.
    In which fields is 2-chloro-5-nitro-4-methylpyridine used?
    2-%-5-carboxyl-4-methylimidazole is useful in a wide range of fields. In this field, it can be used as an important chemical compound in the synthesis of chemical compounds. Due to the properties of chemical compounds, it can be used to build multiple chemical molecules, helping to develop new chemical compounds with specific effects, such as certain inflammatory and disease-replacing compounds.
    In the field of chemical synthesis, it is a synthetic raw material. It can be introduced into different chemical compounds through a series of reactions to improve the molecular properties, such as the solubility and characterization of the whole product, etc., to expand the application of the compound.
    also has a place in the field of materials. Or it can be made of high-performance materials to improve some properties of the material, such as mechanical properties, chemical resistance and corrosion resistance. For example, in the production of special plastics and materials, adding this ingredient can improve the performance of the material as a whole.
    It also plays an important role in the research of biochemistry. It may be used as a bioactive molecule, and some biochemical reactions can be used to explore the production of biological substances, information systems, etc., to help scientists gain a deeper understanding of the basic principles of life. In addition, 2-%-5-carboxyl-4-methylimidazole can demonstrate important application values in many important fields through its unique chemical properties.
    What are the precautions in the preparation of 2-chloro-5-nitro-4-methylpyridine?
    In order to make 2-cyanogen-5-amino-4-methylpyridine, there are several things to pay attention to, which are described as follows:
    The selection of starting materials must be carefully selected. Its purity is very important. Impurities exist in the raw materials, and various side reactions must occur during the reaction, resulting in impure products and reduced yields. Therefore, when purchasing raw materials, high purity is required, and rigorous testing is required to confirm that they are correct before they can be used in the reaction.
    The control of reaction conditions is the key to success or failure. The temperature has a great impact on the reaction rate and product selectivity. This reaction temperature may need to be strictly constant in a specific range, with a slight deviation, or cause the reaction direction to shift, resulting in undesired products. For example, if the temperature is too high, or excessive reaction is triggered, resulting in product decomposition; if the temperature is too low, the reaction will be slow, time-consuming and poor yield. In addition to temperature, conditions such as pressure and reaction time also need to be accurately grasped, and the operation should be carried out according to the pre-planned reaction process, and there must be no mistakes.
    The use of catalysts should be done with caution. Catalysts can change the rate of chemical reactions, but improper selection can lead to adverse consequences. The selected catalyst must not only be able to effectively accelerate the target reaction, but also have high selectivity to ensure that the main generation of 2-cyanogen-5-amino-4-methylpyridine is obtained. During use, the dosage also needs to be accurately calculated, and too much or too little may affect the reaction effect.
    Monitoring of the reaction process is indispensable. Use modern analytical methods, such as chromatography, spectroscopy, etc., to monitor the reaction process in real time. Know the consumption of reactants and the formation of products. If there is any abnormality, the reaction conditions can be adjusted in time to avoid resource waste and product loss.
    Product separation and purification also requires fine operation. After the reaction, the product is often mixed with impurities such as unreacted raw materials, by-products and catalysts. Select suitable separation methods, such as distillation, extraction, crystallization, etc., to purify the target product. The purified product needs to be tested again to ensure that the purity is up to standard before it is a qualified product.
    All of these are the things that should be paid attention to when preparing 2-cyano-5-amino-4-methylpyridine. Any mistake in any link may affect the final result. Only by being careful can high-quality products be prepared.