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2-Chloro-5-iodopyridine, 98% of the main application fields are
2-Chloro-5-iodopyridine, with a purity of 98%, has a wide range of uses and has its own impact in many fields.
In the field of pharmaceutical synthesis, this compound is often a key intermediate. The special structure of the geinpyridine ring has good biological activity and adaptability. Through specific chemical reactions, 2-chloro-5-iodopyridine can be converted into various molecules with pharmacological properties. For example, it can react with specific amine compounds or build the core structure of new antimicrobial drugs to fight against a variety of bacterial infections and protect public health.
It also has important functions in the creation of pesticides. Pyridine derivatives have the characteristics of high efficiency, low toxicity and environmental friendliness. 2-chloro-5-iodopyridine can be used as a starting material to generate pesticides, fungicides and other pesticide products through a series of reactions. For example, synthesizing new pyridine insecticides, they can play a role in the nervous system or physiological and metabolic pathways of specific pests, effectively prevent and control crop pests, ensure the harvest of food, and maintain the prosperity of agriculture.
In the field of materials science, 2-chloro-5-iodopyridine has also emerged. After ingenious design and reaction, it can be introduced into the structure of polymer materials. This endows the material with unique photoelectric properties, which can be used in the preparation of photovoltaic materials such as organic Light Emitting Diodes (OLEDs) or solar cells, or can improve the charge transfer efficiency and stability of the material, promote the progress of electronic materials technology, and bring new opportunities for lighting and energy fields.
2-Chloro-5-iodopyridine, what are the physical and chemical properties of 98%?
2-Chloro-5-iodopyridine, with a content of 98%, has the following physical and chemical properties. This substance is in the form of off-white to yellow crystalline powder, and its morphology is regular. Its melting point is in a specific range, about 85-89 ° C. In this temperature range, the solid phase will gradually transform to the liquid phase.
In terms of solubility, it exhibits certain characteristics in organic solvents. It is easily soluble in halogenated hydrocarbon solvents such as dichloromethane and chloroform, in which it can be well dispersed and dissolved to form a uniform system. In common alcohol solvents such as methanol and ethanol, it also has a certain solubility, but it is slightly inferior to halogenated hydrocarbons. In water, its solubility is very small, and it is difficult to dissolve with water to form a uniform solution. Due to the characteristics of the molecular structure of the substance, the force between it and water molecules is weak.
From the perspective of chemical properties, both chlorine atoms and iodine atoms in 2-chloro-5-iodine pyridine molecules have certain reactivity. Chlorine atoms can participate in nucleophilic substitution reactions. When encountering nucleophiles, nucleophiles can attack the carbon atoms connected to chlorine, and chloride ions leave to form new compounds. Iodine atoms can also participate in reactions under appropriate conditions, such as in coupling reactions catalyzed by certain metals, coupling with compounds containing specific functional groups to build more complex molecular structures. Due to the existence of the pyridine ring, the whole molecule is alkaline and can react with acids under appropriate conditions to form corresponding salt compounds.
2-Chloro-5-iodopyridine, what are 98% of the production methods
2-Chloro-5-iodopyridine, with a content of 98%. The common preparation methods are as follows:
First, 2-amino-5-iodopyridine is used as the starting material. First, 2-amino-5-iodopyridine is mixed with an appropriate amount of sodium nitrite and hydrochloric acid, and the diazotization reaction is carried out at low temperature. This process needs to be carefully controlled to maintain the temperature within a specific range to prevent side reactions from occurring. After the diazo salt is formed, a solution of cuprous chloride hydrochloric acid is added, and the Sandmeyer reaction occurs. The diazo group is replaced by a chlorine atom, thereby preparing 2-chloro-5-iodopyridine. Although the steps of this method are relatively clear, the diazotization reaction conditions are harsh, and the reaction temperature and reagent dosage need to be fine-tuned.
Second, start from 2-chloro-5-bromopyridine. In a specific reaction vessel, add 2-chloro-5-bromopyridine, potassium iodide and an appropriate amount of organic solvents, such as N, N-dimethylformamide (DMF). At the same time, add an appropriate amount of catalysts, such as palladium catalysts, and introduce inert gas to create an oxygen-free environment. The reaction is stirred at a certain temperature, and the bromine atom undergoes a substitution reaction with iodine ions. After separation and purification, the target product 2-chloro-5-iodopyridine can be obtained. This method relies on the substitution characteristics of halogen atoms, but the requirements for reaction equipment and reaction conditions are quite high, and palladium catalysts are expensive and increase costs.
Third, 2-chloropyridine is used as the starting material. First, 2-chloropyridine is iodized, and an iodine source, such as iodine elemental substance, and a suitable oxidant, such as hydrogen peroxide or potassium persulfate, are added to the reaction system, and the reaction is carried out under acidic or basic conditions. 2-Chloro-5-iodopyridine can be obtained by controlling the reaction time, temperature and the ratio of reactants so that the iodine atom selectively replaces the hydrogen atom at the 5 position on the pyridine ring. This route is relatively direct, but the selective control of the iodine substitution reaction is difficult, and it is easy to produce polyiodine by-products.
2-Chloro-5-iodopyridine, 98% What are the precautions in storage and transportation
2-Chloro-5-iodopyridine, with a content of 98%, many matters need to be paid attention to during storage and transportation. This material has certain chemical activity, properties or instability, so when storing, the first environmental conditions. It is advisable to choose a cool, dry and well-ventilated place, away from direct sunlight. Sunlight can cause chemical reactions and damage its quality. Temperature also needs to be strictly controlled. Excessive temperature or decomposition and deterioration are generally recommended to be stored at 5 to 25 degrees Celsius.
Furthermore, the storage place should be kept away from fire and heat sources, because it may be flammable or dangerous to react with fire and heat. It should also be stored separately from oxidizing agents, reducing agents, acids, alkalis, etc., to cover the easy reaction between different chemicals and cause safety accidents.
During transportation, the packaging must be tight and sturdy. Appropriate packaging materials are used to ensure that the product is not damaged and leaked due to vibration and collision. The means of transportation must also be clean, dry, and free of residual substances that can react with it. And transportation personnel should be professionally trained to be familiar with the characteristics of this substance and emergency treatment methods. During transportation, environmental conditions, such as temperature, humidity, etc., should also be closely monitored to ensure transportation safety, so as to achieve the purpose of delivering 2-chloro-5-iodopyridine safely and intact to the destination.
2-Chloro-5-iodopyridine, how reactive is 98% with other compounds?
2-Chloro-5-iodopyridine, purity 98%, the reactivity of this substance with other compounds is related to the mechanism of many chemical changes. Looking at this substance, the presence of chlorine and iodine atoms in its structure endows it with unique reaction characteristics.
Chlorine atoms have certain electronegativity and can be used as leaving groups in nucleophilic substitution reactions. In case of nucleophilic reagents, such as alkoxides, amines, etc., the electron-rich parts of the nucleophilic reagents will attack the carbon atoms connected to chlorine on the pyridine ring, and the chlorine atoms will leave to form new compounds. During this process, the distribution and stability of the electron cloud of the pyridine ring have a significant impact on the reaction rate and product selectivity.
Although the iodine atom has a slightly weaker tendency to leave than the chlorine atom, its larger atomic radius and polarization also affect it. In some reactions, iodine atoms can participate in oxidative addition reactions, especially in transition metal catalysis systems, forming intermediates with metal centers, which can lead to subsequent coupling reactions, such as Suzuki coupling, Stille coupling, etc.
In addition, the pyridine ring of 2-chloro-5-iodine pyridine is basic due to the presence of nitrogen atoms, and can react with acids or form coordination compounds with metal ions. Its reactivity is also affected by reaction conditions, such as temperature, solvent, catalyst, etc. High temperature can generally speed up the reaction rate, specific solvents have an effect on the solubility of reactants and the stability of reaction intermediates, and suitable catalysts can reduce the activation energy of the reaction and promote the reaction. In short, the reactivity of 2-chloro-5-iodopyridine with other compounds is complex, and its structural characteristics and reaction conditions need to be comprehensively considered.
