2 Chloro 5 Hydroxymethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2-Chloro-5-(hydroxymethyl)pyridine

    Specifications

    HS Code

    416688

    Chemical Formula C6H6ClNO
    Molar Mass 143.57 g/mol
    Appearance Solid (usually)
    Physical State At Room Temperature Solid
    Solubility In Water Moderate (due to -OH group)
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
    Melting Point Varies, but typically in a certain range (specific value may need further reference)
    Boiling Point Elevated, specific value depends on purity and conditions
    Odor Typically has a characteristic chemical odor
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents

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    Frequently Asked Questions

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    What are the physical properties of 2-Chloro-5- (hydroxymethyl) pyridine
    2-Chloro-5- (hydroxymethyl) pyridine is also an organic compound. Its physical properties are of great research value.
    First of all, its appearance, at room temperature, is mostly white to light yellow crystalline powder. This form is easy to observe and operate, and its color also provides the basis for preliminary identification.
    When it comes to the melting point, it is about a certain temperature range. The melting point is one of the characteristics of the substance, by which its purity can be preliminarily determined. If the purity is high, the melting point range is narrow; if there are many impurities, the melting point may be offset and the range becomes wider.
    Another is solubility. In organic solvents such as ethanol and acetone, 2-chloro-5- (hydroxymethyl) pyridine exhibits good solubility and can be fused with various solvents. However, in water, its solubility is relatively limited. This property is crucial in the chemical synthesis and separation process, and a suitable solvent can be selected according to its solubility to realize the extraction, separation and reaction of the substance.
    And its density is also an important physical property. The specific density reflects the mass of a substance per unit volume. When chemical production involves material measurement and proportioning, density data is indispensable, which is related to reaction accuracy and product quality.
    In addition, the stability of the compound is also worthy of attention. Under normal environmental conditions, 2-chloro-5- (hydroxymethyl) pyridine has a certain stability. However, under extreme conditions such as high temperature, strong acid, strong base, or chemical reactions, its structure and properties change.
    In summary, the physical properties of 2-chloro-5- (hydroxymethyl) pyridine, such as appearance, melting point, solubility, density and stability, are of great significance in many fields of chemical research and chemical production, laying the foundation for in-depth understanding and rational application of this compound.
    What is the main use of 2-Chloro-5- (hydroxymethyl) pyridine?
    2-Chloro-5- (hydroxymethyl) pyridine, this is an organic compound. It has a wide range of uses and plays an important role in many fields.
    First, in the field of medicinal chemistry, this compound is often used as a key intermediate. The presence of chlorine atoms and hydroxymethyl groups in its structure gives it unique reactivity, and it can construct complex drug molecular structures through various chemical reactions. By reacting with other organic reagents, it can introduce various functional groups, and then synthesize drugs with specific biological activities, such as antibacterial, antiviral or antitumor drugs, which have made great contributions to human health.
    Second, in the field of materials science, 2-chloro-5- (hydroxymethyl) pyridine is also used. Due to its special chemical structure, it can participate in the material synthesis process and improve material properties. For example, introducing it into the synthesis of polymer materials may endow materials with special optical and electrical properties, or enhance material stability and mechanical properties, which is of great significance for the development of new materials.
    Third, in organic synthesis chemistry, it is often used as a basic raw material to synthesize other complex organic compounds. Due to the fact that its functional groups can trigger nucleophilic substitution, electrophilic substitution and many other reactions, it provides rich choices for organic synthesis chemists to help them construct diverse organic molecular structures, expand the variety of organic compounds, and promote the development of organic synthesis chemistry.
    What are the synthesis methods of 2-Chloro-5- (hydroxymethyl) pyridine
    There are many ways to synthesize 2-chloro-5- (hydroxymethyl) pyridine. First, 2-chloro-5-methylpyridine can be used as the starting material, through mild oxidation, with a suitable oxidizing agent, such as a specific peroxide, under specific reaction conditions, the methyl group is gradually converted to hydroxymethyl group. This process requires fine control of the reaction temperature and time to prevent excessive oxidation. Second, using 5- (hydroxymethyl) pyridine as the starting material, through the halogenation reaction, a suitable halogenating reagent is selected, and in the presence of a suitable solvent and catalyst, the chlorine atom is precisely introduced at the second position. The choice of halogenating reagent, the nature of the solvent and the amount of catalyst are all related to the reaction effect. Third, the coupling reaction of pyridine derivatives can be used to ingeniously design intermediates containing chlorine and hydroxymethyl groups. Under the catalysis of specific catalysts and ligands, the relevant groups can be effectively coupled to form the target product. The optimization of catalyst activity and ligand structure is crucial in this process. During synthesis, each method needs to consider the availability of raw materials, the difficulty of controlling reaction conditions, the yield and the purity of the product. After careful consideration and optimization, a satisfactory synthetic effect can be obtained.
    What are the precautions for 2-Chloro-5- (hydroxymethyl) pyridine in storage and transportation?
    2-Chloro-5- (hydroxymethyl) pyridine is a kind of organic compound. During storage and transportation, many matters must be paid attention to.
    First words storage. This compound should be placed in a cool, dry and well-ventilated place. Due to its nature, if it is exposed to high temperature and humidity, it may cause deterioration. For example, high temperature can easily promote chemical reactions, and humidity may cause hydrolysis and other changes, which will damage its quality. In addition, it should be kept away from fires and heat sources to avoid the risk of ignition and explosion. Because of its flammability, it is dangerous to encounter open flames and hot topics. And it needs to be stored separately from oxidizing agents, acids, bases, etc., and cannot be mixed. These numbers meet with 2-chloro-5- (hydroxymethyl) pyridine, which is prone to chemical reactions, causing it to fail or even produce dangerous products.
    Second talk about transportation. When transporting, the packaging must be tight to ensure that there is no leakage. Packaging materials must be able to resist certain external forces to prevent package damage caused by collision and extrusion. Transportation vehicles should also be safe and reliable, and equipped with corresponding fire equipment and leakage emergency treatment equipment. During driving, drivers must be cautious to avoid sun exposure, rain exposure, and high temperature. At the same time, follow the established transportation route and do not stay in densely populated areas and traffic arteries for a long time to prevent accidents and endanger many lives.
    All of these are important for the storage and transportation of 2-chloro-5- (hydroxymethyl) pyridine, which are related to safety and quality and cannot be ignored.
    What are the effects of 2-Chloro-5- (hydroxymethyl) pyridine on the environment and the human body?
    2-Chloro-5- (hydroxymethyl) pyridine is also an organic compound. Its impact on the environment and human body is of great concern to the world.
    When it comes to its impact on the environment, if this compound accidentally enters the natural environment, its fate and fate are very complicated. In the soil, it may be adsorbed on the soil particles, affecting the physical and chemical properties of the soil, and then interfering with the normal activities of soil microorganisms. Microorganisms, the key to the soil ecosystem, are also disturbed by their activities, or cause changes in soil fertility, affecting the growth and development of plants.
    In water bodies, 2-chloro-5- (hydroxymethyl) pyridine may migrate and diffuse with water flow, endangering aquatic organisms. The physiological functions of aquatic organisms, such as respiration, feeding, reproduction, etc., may be adversely affected by it. At high concentrations, it may cause acute poisoning and death of aquatic organisms; long-term low-concentration exposure may also cause bioaccumulation, that is, this compound gradually accumulates in organisms, reaching harmful levels, destroying the population structure of aquatic organisms, and disturbing the balance of aquatic ecology.
    As for the effects on the human body, if people inhale substances containing this compound through the respiratory tract, skin contact or accidental ingestion, the harm cannot be ignored. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing symptoms such as cough, asthma, breathing difficulties. Skin contact, or skin allergies, redness, swelling, itching, and even corrosion and burning of the skin. If ingested into the body by mistake, in the digestive system, or interact with biological macromolecules in the body, interfere with normal physiological and biochemical processes, and affect the function of important organs such as liver and kidney. Long-term exposure to this compound may have a latent risk of mutagenesis and carcinogenesis. Due to its special structure, it may interact with human genetic material DNA, causing gene mutations, which in turn increases the risk of cancer.
    From this perspective, 2-chloro-5- (hydroxymethyl) pyridine has potential hazards to the environment and human body. During its production, use and disposal, careful precautions should be taken to reduce its adverse effects.