2-Chloro-5-fluoropyridine-3-boronic acid

2-Chloro-5-fluoropyridine-3-boronic acid is widely used in the field of organic synthesis. It is often a key building block for the construction of complex organic molecules, and has important functions in many fields such as medicinal chemistry and materials science.
In pharmaceutical chemistry, using this as a raw material can construct drug-active molecules containing pyridine structures through specific reactions. Pyridine rings and their boron groups and halogen atoms can endow molecules with unique physical and chemical properties, which affect their interaction with biological targets. Through coupling reactions, it can be linked with other compounds containing functional groups to expand the structural diversity of molecules and help develop new drugs. < Br >
In the field of materials science, it can participate in the preparation of functional materials. For example, by reacting with other organic or inorganic monomers to form polymers or composites with special optical and electrical properties. Boron-based can enhance the conjugate structure of materials, change their electron cloud distribution, and then affect the properties of materials such as luminescence and conductivity. It is expected to be used in the field of optoelectronic materials, such as organic Light Emitting Diodes, solar cells, etc.
In addition, in the study of organic synthetic chemistry, 2-chloro-5-fluoropyridine-3-boronic acid is used as an organic boron reagent to participate in various boronation reactions, cross-coupling reactions, etc. Due to the difference in activity between boron groups and halogen atoms, it can be selectively chemically converted, providing an effective strategy for the synthesis of organic compounds with specific structures, achieving precise synthesis, and promoting the development of organic synthesis methodologies.

2-Chloro-5-fluoropyridine-3-boronic acid is an important reagent in the field of organic synthesis. It has the following physical properties:
This substance is mostly white to almost white solid under normal conditions. Looking at its color and shape, this property is convenient for preliminary identification and processing in practical operation.
In terms of melting point, it is usually within a certain range, but the exact value will vary slightly due to differences in sample purity and measurement conditions. This property of melting point is of great significance in the purification, identification and monitoring of the synthesis process of substances. By measuring the melting point, the purity of the substance can be judged. If the melting point is consistent with the theoretical value and the melting range is narrow, it often means higher purity; conversely, if the melting range is too wide, it suggests that there may be impurities.
Solubility is also one of the key physical properties. 2-chloro-5-fluoropyridine-3-boronic acid exhibits some solubility in common organic solvents such as ethanol and dichloromethane. In ethanol, it can be partially dissolved at appropriate temperatures and stirring conditions, which allows it to participate in various chemical reactions in the reaction system using ethanol as a solvent. In dichloromethane, the solubility is relatively better, which provides convenience for some reactions that need to be carried out in aprotic solvents. In water, its solubility is relatively limited, but not completely insoluble. This difference in solubility allows chemists to make appropriate choices according to the needs of the reaction when designing the synthesis route and selecting the reaction solvent to ensure the smooth progress of the reaction and the efficient generation of the product.

There are several common methods for synthesizing 2-chloro-5-fluoropyridine-3-boronic acid.
First, halopyridine derivatives are used as starting materials. First, take an appropriate halopyridine, such as 2-chloro-5-fluoropyridine, and make it react with organometallic reagents, such as n-butyllithium, to form a lithiated intermediate. This lithiated intermediate has high activity and can react with borate esters, such as trimethoxyborate. After the reaction is completed, 2-chloro-5-fluoropyridine-3-boronic acid can be obtained through a hydrolysis step. In this process, factors such as the amount of organometallic reagents added, the reaction temperature and time have a great influence on the formation of the product. Precise temperature control is required, and the lithium reaction is generally carried out at a low temperature such as -78 ° C to ensure the selectivity of the reaction and avoid side reactions.
Second, the method of transition metal catalysis is used. Using 2-chloro-5-fluoropyridine as the substrate, a transition metal catalyst such as tetra (triphenylphosphine) palladium (0) is added. And ligands, such as tri-tert-butyl phosphine, are added to enhance the activity and stability of the catalyst. At the same time, under basic conditions, such as the presence of potassium carbonate and other bases, the boronylation reaction can be achieved through a series of complex catalytic cycles to obtain the target product. In this method, the type and amount of catalyst, ligand structure, strength and amount of base are all key factors. Different catalysts and ligand combinations will significantly affect the reaction rate and yield.
Third, the coordination guidance of the nitrogen atom of the pyridine can be used. The pyridine ring can be modified first, and groups with guiding effect can be introduced to enhance the selectivity of the boration reaction at specific positions. After that, under the action of suitable boronation reagents, such as pinacol borane, the boron group is selectively introduced into the target position through transition metal catalysis or other promotion methods, and then the guide group is removed after appropriate post-treatment to obtain 2-chloro-5-fluoropyridine-3-boronic acid. This strategy focuses on the design and selection of the guide group, which not only ensures its effective guidance, but also facilitates subsequent removal without affecting the structure and purity of the product.

2-Chloro-5-fluoropyridine-3-boronic acid, when storing and transporting, pay attention to many matters.
This is a chemical substance, which is active or active, and is prone to change in case of moisture. When storing, be sure to place it in a dry place, away from water and moisture. If it is in a humid environment, the boric acid part may interact with water, causing its purity to be damaged and affecting subsequent use.
Temperature is also critical. It should be stored in a cool place, away from high temperature and fire sources. Under high temperature, it may react chemically and even pose a safety risk. Excessive temperature may cause reactions such as decomposition and polymerization, changing the chemical structure and properties.
When transporting, the packaging must be solid and stable. When using suitable containers, prevent it from leaking. If this substance leaks, or pollutes the environment, it endangers people and animals. Packaging materials should be resistant to chemical corrosion and can effectively protect.
In addition, during transportation, it should be smooth to avoid violent vibrations and collisions. Vibration, collision or damage to the container, causing the substance to leak. And the transportation environment should also be temperature-controlled and humidity-controlled according to its characteristics to ensure its stability.
Furthermore, relevant laws and standards should be followed regardless of storage or transportation. Operators should have professional knowledge and skills, familiar with the characteristics of the substance and safety precautions, so as to ensure the safety of storage and transportation.

I look at your question, and I am inquiring about the market price of 2-chloro-5-fluoropyridine-3-boronic acid. The price of this chemical product often changes due to multiple reasons.
First, the supply and demand of the market, if there are many people who want it and there are few people who supply it, the price will be high; on the contrary, if the supply exceeds the demand, the price will be low. Second, the cost of making this product is also a major factor. The price of raw materials, the simplicity of the process, and the amount of energy consumption can all affect the cost, which in turn affects the price. Third, the purity of the product is also related to the price. The higher the purity, the more expensive the price.
In the past market, the price of such fine chemicals often fluctuated. However, today is different from the past, and the market situation is fickle. According to past experience, the price per gram of ordinary purity may be around tens of yuan to 100 yuan; if it is high purity, especially suitable for high-end medicine or electronics, the price per gram may exceed 100 yuan or even higher. But this is just speculation, and the actual price needs to be consulted with chemical raw material suppliers or real-time market conditions to be sure.