2 Chloro 5 Fluoro 4 Methylpyridine
pyridine pyrrole pyrazine piperidine piperazine

2-chloro-5-fluoro-4-methylpyridine

    Specifications

    HS Code

    837135

    Chemical Formula C6H5ClFN
    Appearance colorless to light yellow liquid (usually)
    Boiling Point approx. 180 - 185 °C
    Melting Point N/A (usually liquid at room temp)
    Density approx. 1.28 - 1.32 g/cm³
    Solubility In Water poorly soluble
    Solubility In Organic Solvents soluble in many organic solvents like ethanol, acetone
    Flash Point approx. 70 - 75 °C
    Odor characteristic pyridine - like odor
    Purity usually sold with high purity, e.g., 95%+
    Cas Number 52334-81-3

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    General Information
    Where to Buy 2-chloro-5-fluoro-4-methylpyridine in China?
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    Frequently Asked Questions

    As a leading 2-chloro-5-fluoro-4-methylpyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-chloro-5-fluoro-4-methylpyridine?
    The main use of 2-% N-5-oxo-4-methylpyridine is not directly reported in the "Tiangong", but it can be used to promote the principle of phase chemization and the use of similar compounds.
    In ancient times, the concept of refinement was replaced, but it has been used for similar compounds. This nitrogen-containing compound may have its role in some dyeing and extraction processes. For example, in ancient dyeing techniques, some nitrogen-containing compounds can be used as mordants to help dyes adhere better to the dye. If 2-% N-5-oxo-4-methylpyridine has similarity, it can be used to improve the fastness of dyes and make the dyeing effect last longer.
    In terms of application, ancient natural plants and materials have been studied in depth, and some nitrogen-containing compounds are biologically active. Direct results show that 2-% N-5-oxo-4-methylpyridine is useful in ancient methods, but similar compounds are recommended, or have certain biological effects. For example, some inflammation and pain may have an antidote effect, but the ancients did not understand and utilize it in a modern way.
    In addition, in ancient artifacts, microorganisms may produce nitrogen-containing byproducts, and this product or leaven process and product taste have a shadow. 2-% -5-oxo-4-methylpyridine or in some special leavens, as a microbial agent or factor in the formation of flavors, flavors, and flavors of wines, wines, and other leavens.
    What are the physical properties of 2-chloro-5-fluoro-4-methylpyridine?
    2-%-5-ene-4-methylnonane, this is a special compound. Its physical properties are very special, let me tell you.
    First of all, under normal conditions, 2-%-5-ene-4-methylnonane is mostly liquid. This is due to the molecular force of the compound, including Vander force, etc., so that under normal conditions, the degree of molecular aggregation is low. Its boiling is affected by molecular behavior and interactions. It is estimated that, at a certain level, the existence of molecular carbon density, branching, and the existence of the molecule is difficult. With the increase of carbon, the molecular force increases, and the boiling force increases; while the number of branches increases, the molecular distance increases, the force is weak, and the boiling force decreases slightly; the existence of the carbon also changes the molecular interaction.

    and melting, 2-%-5-ene-4-methylnonane also has a specific value. The integrity of its molecules and the way they are arranged with each other determine the level of melting. The molecules are not so dense and orderly, so the melting phase is not high.
    Redensity, phase water, 2-%-5-ene-4-methylnonane density is small, often floating above the water surface. This is due to the presence of the constituent elements and molecules of the chemical compound, so that the amount of water in its position is low.
    In terms of solubility, the chemical compound does not have a chemical substance, and the principle of similar phase solubility is similar to that of the root. It is easily soluble in water such as hexane and ether, but soluble in water. This is because of the water-based molecules, while the 2-%-5-ene-4-methylnonane molecule is very weak, and the two molecules act together to overcome the cohesion of each other, so they are insoluble.
    In terms of solubility, 2-%-5-ene-4-methylnonane has a certain solubility. Its molecular energy is sufficient to overcome the surface force of the liquid, escape from the liquid surface, and form a vapor. This property also affects its boiling and molecular force phase. The lower the boiling, the weaker the molecular force, and the more difficult the phase.
    What are the chemical properties of 2-chloro-5-fluoro-4-methylpyridine?
    2-%-5-oxo-4-methylpyridine, this compound is an organic compound with unique chemical properties.
    First of all, in terms of its stability, the presence of pyridine rings in the molecular structure endows it with a certain degree of stability. Pyridine rings are aromatic, which makes the compound less prone to violent reactions such as ring opening under normal conditions. However, the substituents on its rings, such as methyl groups, will have a subtle impact on its stability. The electron carrier effect of methyl groups will change the electron cloud density distribution of pyridine rings to a certain extent, affecting its chemical activity.
    From the perspective of acidity and alkalinity, the nitrogen atom in the pyridine ring has a pair of lone pairs of electrons, which makes 2-% -5-oxo-4-methylpyridine have a certain alkalinity. It can react with acids and accept protons to form salts. However, due to the presence of substituents on the ring, its alkalinity will change. For example, the electron cloud density on the nitrogen atom can be increased by the action of methyl groups, which in turn enhances its alkalinity.
    Regarding its reactivity, this compound can undergo a variety of reactions. In terms of electrophilic substitution reactions, due to the uneven distribution of electron cloud density in the pyridine ring, the reaction mainly occurs at the position where the electron cloud density on the pyridine ring is relatively high. The properties and positions of the substituents can affect the regioselectivity of the reaction. For example, the electron cloud density of the adjacent and para-sites of the methyl group is relatively high, and electrophilic reagents are more inclined to attack these positions.
    In addition, 2-% -5-oxo-4-methylpyridine may also participate in the redox reaction. The oxygen atoms and pyridine rings in its molecules will undergo corresponding oxidation or reduction changes under the action of appropriate oxidizing agents or reducing agents, resulting in the formation of different products.
    Furthermore, in the field of organic synthesis, it is often used as an important intermediate. With its unique structure and chemical properties, it can introduce other functional groups through a series of chemical reactions to build more complex organic molecular structures, which have shown important application value in many fields such as medicinal chemistry and materials science.
    What are the synthesis methods of 2-chloro-5-fluoro-4-methylpyridine?
    The synthesis of 2-% heptyl-5-ene-4-methylpyridine is often related to the delicate skills of organic chemistry. To obtain this compound, various approaches can be followed.
    First, it can be started from the starting material containing the pyridine ring. First, find a suitable substituted pyridine. If the 4-position of the pyridine has a methyl group, a suitable substituent containing alkenyl and heptyl groups can be introduced into the 2-position of the pyridine. This process requires the help of delicate organic reactions, such as nucleophilic substitution reactions. First, a strong base is used to generate carbon anions at the 2-position of pyridine, and then it reacts with halogenated hydrocarbons containing alkenyl and heptyl groups. The halogenated hydrocarbons need to have alkenyl bonds and heptyl groups at suitable positions. The reaction conditions need to be carefully controlled, and the choice of temperature and solvent is the key. If the temperature is too high or too low, the reaction rate and selectivity may be affected. Suitable solvents, such as polar aprotic solvents, can promote the nucleophilic substitution reaction.
    Second, a step-by-step construction strategy can be adopted. The carbon chain containing heptyl and alkenyl groups is first constructed, and then the carbon chain is introduced into the pyrid For example, through the Wittig reaction, a suitable phosphine ylide is reacted with a carbonyl-containing compound to form an alkenyl moiety, which is then increased to heptyl through a carbon chain growth reaction. Then, through the synthesis of pyridine rings, such as a variant of the Hantzsch pyridine synthesis method, this carbon chain is introduced into the pyridine ring system, and the 4-position of the pyridine ring is introduced into the methyl group. This process requires precise control of the reaction conditions at each step to ensure the smooth progress of the reaction and the purity of the product.
    Third, the reaction path of transition metal catalysis can also be considered. Transition metal catalysts, such as palladium catalysts, are used to catalyze the coupling reaction of pyridine-containing ring substrates with alkenyl, heptyl and methyl-containing halogenates or olefin derivatives. This method requires the selection of suitable ligands to enhance the activity and selectivity of the catalyst. Suitable ligands can make the reaction more regioselective, introducing alkenyl and heptyl groups precisely at the 2-position of the pyridine ring, and retaining methyl at the 4-position. In the reaction, the anhydrous and oxygen-free conditions of the reaction system are quite high. Small amounts of moisture or oxygen may deactivate the catalyst and affect the reaction process.
    What is the price range of 2-chloro-5-fluoro-4-methylpyridine on the market?
    The price of 2-%-5-pente-4-methylheptane is often determined by many factors, such as the supply and demand of raw materials, the ease of extraction, the market price, and the cost of storage.
    If the supply of raw materials is abundant, and the market demand is relatively flat, its price or price is determined and reasonable. However, if the supply of raw materials encounters a sudden shortage, such as the local production is blocked due to natural or political factors, and the market demand does not increase, the price will increase.
    Furthermore, if the production of this compound is expensive and expensive, it requires a large amount of energy, special catalysts or high-quality products, and the cost of the most cost-effective products will also be high. On the contrary, if a breakthrough is made in the development technology, the cost will be greatly reduced, and the price is expected to fall.
    The market price of this compound is also low. If there is a large number of suppliers, and each other is fierce, the market share will be reduced, and the price will be reduced. On the contrary, if the market price is close to low, and there are few suppliers, the price may be controlled by few suppliers, which is easy to be high.
    The cost and the cost of storage should also not be ignored. If this item requires a special product, such as low cost, addition cost, or a specific storage environment to ensure its quality, the cost and storage cost will be included in the product price, which will affect its market sales.
    As mentioned above, the market price of 2-% -5-e-4-methylheptane is low. Due to the interaction of the above-mentioned factors, the value of the cut can be determined, which may range from 10 yuan per gram to 100 yuan per gram, depending on the market situation below.