2-Chloro-5-fluoro-3-hydroxypyridine

2-Chloro-5-fluoro-3-hydroxypyridine is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. Due to its unique chemical structure and activity, it can participate in a variety of chemical reactions and help synthesize compounds with specific pharmacological activities. In the process of drug development, it can be used to build a specific molecular skeleton to create new drugs with curative effects on specific diseases.
In the field of pesticide chemistry, 2-chloro-5-fluoro-3-hydroxypyridine is also indispensable. With its chemical properties, it can be used to synthesize pesticides with high insecticidal, bactericidal or herbicidal properties. Through clever design and chemical reaction, the prepared pesticides are highly selective and active to target organisms, while reducing the adverse effects on the environment and non-target organisms.
In addition, in the field of materials science, it also shows potential application value. Because it can be introduced into polymer materials by chemical reaction, it can give materials special properties, such as improving the stability, optical properties or electrical properties of materials, so as to expand the application of materials in different fields.
Therefore, 2-chloro-5-fluoro-3-hydroxypyridine plays an important role in the fields of medicine, pesticides and materials science, providing key support and assistance for the development of related fields.

2-Chloro-5-fluoro-3-hydroxypyridine is one of the organic compounds. It has many physical properties, which are described in detail below.
Looking at its appearance, under room temperature and pressure, it is mostly white to light yellow crystalline powder. This shape is easy to observe and handle. In many experiments and industrial processes, this appearance characteristic is conducive to accurate measurement and operation.
When it comes to melting point, it is between 130-135 ° C. Melting point is an important physical constant of a substance, which is of great significance for the identification of the purity of compounds. If the purity of the substance is extremely high, the melting point range is usually narrow; if it contains impurities, the melting point may decrease and the melting point range becomes wider.
Its solubility is also worthy of attention. 2-Chloro-5-fluoro-3-hydroxypyridine is slightly soluble in water. This property is related to its molecular structure. Although the molecule contains hydroxyl groups, it can form hydrogen bonds with water, but the presence of chlorine atoms and fluorine atoms increases the hydrophobicity of the molecule, resulting in limited solubility in water. However, it is soluble in common organic solvents such as ethanol, dichloromethane, N, N-dimethylformamide (DMF), etc. In organic synthesis, choosing a suitable solvent to dissolve this substance is crucial for the smooth progress of the reaction.
In addition, 2-chloro-5-fluoro-3-hydroxypyridine also has certain stability. However, under certain conditions, such as high temperature, strong acid, strong alkali environment, or chemical reaction, the structure changes. Therefore, when storing, it should be placed in a cool, dry and well-ventilated place to avoid contact with strong acids, bases and oxidants to ensure its chemical stability.
The above are all common physical properties of 2-chloro-5-fluoro-3-hydroxypyridine. In the fields of organic synthesis and drug development, in-depth understanding of these properties can help researchers make better use of this compound.

The stability of the chemical properties of 2-chloro-5-fluoro-3-hydroxypyridine depends on many reasons. In this compound, chlorine, fluorohalogen atoms and hydroxyl groups are combined on the pyridine ring. The halogen atom has electron-withdrawing properties, and the hydroxyl group has the energy of a electron supplier. The interaction between the two makes the chemical properties of the compound complicated.
In terms of stability, the pyridine ring has a certain aromaticity, but the substitution of the halogen atom and the hydroxyl group slightly changes the electron cloud density distribution. The strong electron-withdrawing effect of chlorine and fluorine reduces the electron cloud density of the pyridine ring and weakens the stability of the ring. Although the hydroxyl group has the effect of electron conjugation, it can compensate the electron cloud density to a certain extent, but it is difficult to completely cancel the effect of halogen atoms.
In terms of chemical reactivity, due to the existence of halogen atoms, this compound is prone to nucleophilic substitution reactions, and halogen atoms can be replaced by nucleophilic reagents. Hydroxyl groups are also active and can participate in esterification, etherification and other reactions. And because of the alkalinity of the pyridine ring, the compound can form salts with acids.
In air, due to the easy oxidation of hydroxyl groups, the stability is poor, or gradually changes. And in case of high temperature, light and other conditions, halogen atoms may be removed, causing structural changes. In summary, the chemical properties of 2-chloro-5-fluoro-3-hydroxypyridine are not extremely stable, and it is necessary to pay attention to environmental factors during storage and use to prevent its deterioration.

The synthesis method of 2-chloro-5-fluoro-3-hydroxypyridine is of great interest in the field of chemical synthesis. The synthesis method can be explored from different paths.
One, or it can be prepared by a series of reactions such as halogenation and hydroxylation starting from a compound containing a pyridine structure. For example, a suitable pyridine derivative is chlorinated first, and a chlorine atom is introduced at a specific location. For this chlorination reaction, an appropriate chlorination reagent, such as phosphorus oxychloride, dichlorosulfoxide, etc., needs to be selected. The control of reaction conditions is also critical. Temperature, reaction time, etc. all affect the yield and selectivity of chlorinated products.
Next, fluorine atoms are introduced at appropriate steps. The method of introducing fluorine atoms can be used for nucleophilic substitution reaction, and fluorine-containing reagents interact with intermediates. This process requires attention to the activity and reaction conditions of the reaction substrate. Due to the introduction of fluorine atoms, the reaction activity and selectivity are greatly affected.
Furthermore, the introduction of hydroxyl groups can be achieved by hydrolysis, oxidation and other reactions. If there are suitable functional groups such as ester groups and ether groups, hydroxyl groups can be obtained by hydrolysis. The conditions of hydrolysis reaction vary depending on the substrate, and may require acid or base catalysis, and the temperature also needs to be precisely regulated.
Second, there is also a strategy to synthesize 2-chloro-5-fluoro-3-hydroxypyridine by constructing pyridine rings. It can be cyclized by suitable small molecules, such as compounds containing nitrogen, carbon, and halogen atoms, to form pyridine rings. In this process, chlorine, fluorine, and hydroxyl groups are introduced simultaneously or step by step. The mechanism of cyclization is complex, and factors such as the ratio of reactants, the pH of the reaction environment, and the choice of catalyst need to be considered.
There are various methods for synthesizing 2-chloro-5-fluoro-3-hydroxypyridine, and each method has its own advantages and disadvantages. The appropriate synthesis path should be carefully selected according to the actual situation, such as the availability of raw materials, cost, and purity requirements of the target product.

The price of 2-chloro-5-fluoro-3-hydroxypyridine in the market varies due to changes in market conditions, differences in quality, and different quantities purchased. In the past, the price of this chemical fluctuated due to the balance of supply and demand and manufacturing costs.
If the quantity is small, it can be purchased in ordinary chemical reagent stores, and the price per gram may be in the tens of yuan. However, if it is a large enterprise, due to the needs of production, it can be purchased in batches. If it is purchased in batches, such as hundreds or even thousands of grams at a time, the price may be reduced due to the benefit of scale, and the price per gram may be reduced to several yuan. < Br >
And its price is also affected by the raw material market. If the raw materials for synthesizing this product are abundant and cheap, its price may decline; on the contrary, if the price of raw materials scarcity increases, the price of 2-chloro-5-fluoro-3-hydroxypyridine will also rise. In addition, the quality of goods from different origins is good and bad, and the price is also different. The price of refined products is higher than that of ordinary products. Because of its purity and less variety, it is more suitable for high-end applications. In short, to know the exact price, you need to consult all chemical suppliers, and explore in detail according to the current situation and purchase quantity.