2-Chloro-5-flioro-4-(hydroxymethyl)pyridine

2-Chloro-5-fluoro-4- (hydroxymethyl) pyridine is widely used. In the field of medicinal chemistry, it is often used as a key intermediate. It plays an important role in many drug synthesis pathways, like the creation of some antibacterial drugs. Through its unique chemical structure, it can interact with specific biomolecules to help build a drug activity skeleton, thereby giving the drug excellent antibacterial efficacy.
In the field of pesticide chemistry, it also shows important value. It can be used as a raw material to participate in the synthesis of new pesticides. The chlorine, fluorine atoms and hydroxymethyl structure of the synthesized pesticides make the synthesized pesticides targeted and efficient in insecticides, sterilization or weeding, which is of great significance for ensuring the healthy growth of crops and improving yields.
There are also potential uses in the field of materials science. Due to its special functional groups, it may be used to prepare polymer materials with specific properties, such as by polymerizing with other monomers, giving the material unique electrical, optical or mechanical properties, and expanding new directions for the research and development of new materials. Overall, 2-chloro-5-fluoro-4- (hydroxymethyl) pyridine occupies an important position in the research and production practice of many disciplines, and plays a significant role in promoting the development of related industries.

The synthesis method of 2-chloro-5-fluoro-4- (hydroxymethyl) pyridine has been explored by chemists throughout the ages, and the methods are also diverse. The following are common types:
First, the compound containing the pyridine structure is used as the starting material. Select a suitable halogenated reagent to halogenate the pyridine ring at a specific position, and introduce chlorine and fluorine atoms. After that, through a series of reactions, hydroxymethyl groups are introduced at the designated position. This process requires fine control of the reaction conditions, such as temperature, pH, and reaction time. If the temperature is too high or too low, it may increase the side reactions and reduce the yield. Improper pH will also affect the reaction process and product purity.
Second, the strategy of gradually constructing the pyridine ring is adopted. First, the pyridine ring is constructed by condensation, cyclization and other reactions based on small molecule compounds. During this period, the introduction sequence of substituents is rationally planned, and chlorine, fluorine and hydroxymethyl are introduced in sequence. This method requires quite high design of the reaction steps, and the intermediates in each step need to be properly handled and purified to prevent the accumulation of impurities and affect the quality of the final product.
Third, the reaction is catalyzed by transition metals. Transition metal catalysts can effectively promote the formation of carbon-heteroatomic bonds. When synthesizing this compound, their characteristics can be used to achieve precise introduction of chlorine and fluorine atoms, and hydroxymethylation reactions. However, the price of transition metal catalysts is often higher, and the post-reaction treatment needs to consider catalyst separation and recovery to reduce costs and environmental impact.
Synthesis of 2-chloro-5-fluoro-4- (hydroxymethyl) pyridine requires considering the advantages and disadvantages of each method according to the actual situation, carefully selecting the appropriate synthesis route, and strictly controlling the reaction conditions to obtain the product with ideal yield and purity.

2-Chloro-5-fluoro-4- (hydroxymethyl) pyridine, this is an organic compound. Its physical properties are unique. Under normal temperature and pressure, it mostly exists in a solid state. White or off-white crystalline powders are common, and they are fine and uniform in appearance.
When it comes to the melting point, it is about a specific range, but it varies depending on the impurities and the measurement conditions, roughly around [X] ° C. This temperature characteristic is closely related to the crystalline structure and the intermolecular forces. In terms of boiling point, it needs to be measured under specific pressure conditions, and it usually boils at a higher temperature, reflecting the strength of the intermolecular forces.
Solubility is also a key physical property. In organic solvents, such as methanol, ethanol, dichloromethane, etc., it has a certain solubility. Because the compound contains polar group hydroxymethyl, it can be miscible with polar organic solvents by hydrogen bonding. The solubility in water is relatively limited, but moderate stirring or heating can increase its solubility, because the interaction between water molecules and polar groups has a certain limit.
Density is also an important physical property. Its density value reflects the degree of tight packing of molecules, which is of great significance in practical applications, such as separation and mixing processes.
In addition, the compound has certain stability and can maintain its own structure and properties under conventional storage conditions. However, when encountering special chemical reagents such as strong oxidizing agents, strong acids and bases, or extreme environments of high temperature and high humidity, their structures may change, resulting in changes in physical properties. Understanding these physical properties is indispensable for their synthesis, purification, storage and application.

2-Chloro-5-fluoro-4- (hydroxymethyl) pyridine, this is an organic compound. Its chemical properties are unique and crucial.
Let's talk about its hydrophilicity first. Due to the presence of hydroxymethyl (-CH OH ²), the hydroxyl group can form hydrogen bonds with water molecules, so the compound has a certain hydrophilicity and solubility in water or some polar solvents. This property is very important in separation, purification and reaction medium selection.
Let's talk about its reactivity. Both chlorine and fluorine atoms are halogen atoms. Halogen atoms have an electron-absorbing induction effect, which will reduce the electron cloud density of the pyridine ring, making the pyridine ring more susceptible to nucleophilic attack. For example, under appropriate conditions, chlorine atoms can be replaced by nucleophiles to form various derivatives. The hydroxyl groups in hydroxymethyl groups have certain reactivity, and reactions such as esterification and oxidation can occur. In case of suitable oxidizing agents, the hydroxyl groups can be oxidized to aldehyde groups or even carboxylic groups; under the action of carboxylic acids or anhydrides in catalysts, esterification reactions can occur to generate corresponding ester compounds.
Because the pyridine ring is aromatic, it is relatively stable, but it can also participate in some typical reactions of aromatic compounds, such as electrophilic substitution reactions. However, due to the electron absorption of chlorine and fluorine atoms, the electrophilic substitution reaction activity is lower than that of the benzene ring, and the substitution position will be affected by the positioning effect of these substituents.
In addition, there are interactions between different functional groups in this compound. The electron-absorbing effect of fluorine atom and chlorine atom may affect the reactivity of hydroxymethyl group. On the contrary, the influence of hydroxymethyl group on the electron cloud distribution of pyridine ring will also change the reactivity of halogen atom substitution.
2-chloro-5-fluoro-4- (hydroxymethyl) pyridine has rich chemical properties. In the field of organic synthesis, these properties can be used to construct compounds with diverse structures and have broad application prospects.

I don't know what the market price range of 2-chloro-5-fluoro-4- (hydroxymethyl) pyridine is. However, if you want to know its price, you can explore it from various channels.
First, the chemical raw material trading platform. Now many such platforms gather many suppliers and buyers, and there may be sales information of this compound on them. Looking at the prices of different merchants, you can get a glimpse of the price range.
Second, ask the chemical raw material suppliers. Many suppliers specializing in chemical products are quite familiar with the price of various types of compounds. You can ask several suppliers about the price of this compound by phone, email, etc., and synthesize the replies of each company to get a more accurate price range.
Third, participate in the chemical industry exhibition. At the exhibition, companies display their products and can also communicate with industry insiders. Here, you can not only understand the price of this compound, but also gain insight into the industry dynamics and market supply and demand trends.
Fourth, check industry reports and information. The chemical industry often publishes relevant reports, which may contain specific compound price trends and market analysis. Through professional information platforms, industry magazines, etc., you can obtain such information to assist in speculating on the price range.
It is unfortunate that I cannot directly tell you the exact price range of this compound, but according to the above methods, you must be able to get the answer you need.