2-chloro-5-(cyanomethyl)pyridine

2-Chloro-5- (cyanomethyl) pyridine is widely used in the chemical and pharmaceutical fields.
Preface chemical industry. It is a key intermediate in organic synthesis, and can undergo various chemical reactions to obtain complex organic compounds. For example, in the development of new materials, it can participate in the construction of polymer polymers with special properties. By carefully designing the reaction path, using 2-chloro-5- (cyanomethyl) pyridine as the starting material and condensing with specific monomers, it can be used to obtain materials with unique electrical, optical or mechanical properties, which may be useful in the fields of electronics and optical instrument manufacturing.
As for the field of medicine, its importance cannot be underestimated. It is often used as a key building block for synthesizing drug molecules. In many drug research and development projects, based on the characteristics of its molecular structure, it can be modified to obtain compounds with specific pharmacological activities. For example, in the development of anti-cancer drugs, by modifying its structure, introducing suitable functional groups may improve the targeting and inhibitory activity of cancer cells. In the development of antibacterial drugs, the molecular structure based on 2-chloro-5- (cyanomethyl) pyridine may enhance the inhibitory ability of specific pathogens, providing a new way for the development of antibacterial drugs.
In summary, 2-chloro-5- (cyanomethyl) pyridine, with its unique structure, is an indispensable substance in the chemical industry and medicine, and has great contributions to promoting the development of related fields.

There are several methods for synthesizing 2-chloro-5- (cyanomethyl) pyridine.
First, 2-chloro-5-methylpyridine can be used. First, the methyl of 2-chloro-5-methylpyridine is oxidized to a carboxyl group with a suitable oxidant, such as potassium permanganate, etc., to obtain 2-chloro-5-pyridine carboxylic acid. This process requires attention to the reaction temperature and the amount of oxidant. If the temperature is too high or the oxidant is too excessive, the pyridine ring may be damaged. Then 2-chloro-5-pyridinecarboxylic acid is converted into acyl chloride, commonly used chlorination reagents such as dichlorosulfoxide, and the reaction conditions should be mild to avoid side reactions. Then the acyl chloride is reacted with sodium cyanide in a suitable solvent, and a cyanyl group can be introduced to obtain 2-chloro-5- (cyanomethyl) pyridine.
Second, 2-chloro-5-chloromethylpyridine is used as a raw material. The chloromethyl of this compound has high reactivity and can react with sodium cyanide or potassium cyanide in polar solvents such as N, N-dimethylformamide (DMF). The reaction needs to be fully stirred to ensure uniform contact of the reactants and improve the reaction efficiency. This reaction follows the nucleophilic substitution mechanism. The cyanyl negative ion attacks the carbon atom of the chloromethyl group, and the chloride ion leaves to obtain the target product.
Third, it can also be achieved by the metal-catalyzed coupling reaction of pyridine derivatives. For example, first prepare pyridine borate or pyridine halide containing suitable substituents, and halide or halide-like compounds containing cyanomethyl groups. Under the action of metal catalysts and ligands such as palladium, the coupling reaction is carried out under suitable reaction conditions. This method requires strict reaction conditions, and the choice of catalyst, the type and dosage of reaction solvent and base all have a significant impact on the reaction results. It is necessary to fine-tune the reaction parameters to improve the yield and purity of the target product.

2-Chloro-5- (cyanomethyl) pyridine is an important compound in organic chemistry. Its physical properties are crucial and have a profound impact on chemical research and application.
Looking at its properties, under room temperature and pressure, this substance is often in a solid state, although the specific state may vary slightly depending on the purity and environmental conditions. Its color is usually white to light yellow, just like the purity of the first snow in winter and the elegance of the afterglow at dusk. This color can help chemists to preliminarily determine its purity in experiments.
When it comes to melting point, it is within a specific temperature range, and the specific value will fluctuate according to the measurement method and conditions. The characteristics of the melting point, like the unique "temperature imprint" of a substance, provide an important basis for chemists to identify and purify the compound. Just as the ancients used the unique imprint to identify precious things, the melting point is equally important for this compound.
In terms of boiling point, it is also in a certain temperature range. The boiling point reflects the conditions under which the substance changes from liquid to gaseous state, which is crucial for the separation and purification process. In the chemical industry, precise control of the boiling point can achieve efficient separation and obtain high-purity products, just like craftsmen carefully carve, to achieve high-quality products.
In terms of solubility, 2-chloro-5- (cyanomethyl) pyridine exhibits good solubility in organic solvents such as dichloromethane and chloroform, but it is difficult to dissolve in water. This property is of great significance in organic synthesis reactions, and chemists can choose suitable solvents according to this to promote the smooth progress of the reaction. This is like choosing a clever tool to make chemical synthesis work twice as much with half the effort.
In addition, the density of the compound also has a specific value. As one of the basic properties of the substance, density is indispensable in experimental operations and industrial production of materials. It is like a scale to measure the "weight and volume relationship" of the substance, ensuring the accuracy of the production process.
The physical properties of 2-chloro-5- (cyanomethyl) pyridine, from their properties, melting point, boiling point, solubility to density, are all related to each other on precision instruments, together laying the foundation for chemical research and application, helping chemists move forward steadily on the road to exploring the mysteries of organic chemistry.

2-Chloro-5- (cyanomethyl) pyridine, this is one of the organic compounds. It has unique chemical properties, let me tell you one by one.
First of all, its structure, cyano-CN and chlorine atom-Cl are respectively connected to specific positions in the pyridine ring. Cyanyl is active and has strong electron absorption, and is often a reactive check point in chemical reactions. Because of its carbon-nitrogen triple bond, it can participate in nucleophilic addition, hydrolysis and many other reactions. In case of water and acid, cyanyl can be hydrolyzed to carboxyl-COOH or amide-CONH ².
Furthermore, chlorine atoms are also important activity check points on the pyridine ring. Chlorine atoms have certain electronegativity, which changes the electron cloud distribution of the pyridine ring. It can undergo nucleophilic substitution reactions, and many nucleophilic reagents, such as alkoxides and amines, can replace chlorine atoms to form new compounds.
The pyridine ring itself is aromatic, and the electron cloud distribution is uniform and relatively stable. However, due to the influence of cyanyl and chlorine atoms, its electron cloud distribution is uneven and the reaction activity is modulated.
2 -chloro-5- (cyanomethyl) pyridine has a wide range of uses in the field of organic synthesis due to its above activity check points and structural characteristics. Often an intermediate, it can prepare drugs, pesticides and functional materials through a series of reactions. For example, through a specific reaction route, it can synthesize biologically active drug molecules, which is of great significance in pharmaceutical research and development.

2-Chloro-5- (cyanomethyl) pyridine is in the market, and its price range is difficult to determine. The price of this compound often varies due to various factors. First, the amount has a great impact. If the purchase quantity is huge, the price may be discounted, so that the merchant hopes to increase the sales volume and obtain a big profit; if the purchase quantity is small, the unit price may be higher, and the cost of packaging, transportation, etc. is spread over a small amount of goods, resulting in a high price. Second, the source is different, and the price is also different. If it is refined by an excellent factory and has good quality, the price may be slightly higher; if it is commonly made, the quality is slightly inferior, and the price may be slightly cheaper. Third, the supply and demand of the market is the main reason. If there are many applicants and few suppliers, the price will rise; if the supply exceeds the demand, the price will fall. Generally speaking, in the market of chemical raw materials, the price of 2-chloro-5- (cyanomethyl) pyridine ranges from a few yuan to a few tens of yuan per gram. However, this is only a rough estimate. The actual price should be checked with the suppliers of chemical raw materials and their quoted prices before the exact number can be obtained. Due to the rapidly changing market conditions, prices often fluctuate, so it is wise to consult the real-time price in detail.