2-Chloro-5-cyano-3-methylpyridine

2-Chloro-5-cyano-3-methylpyridine is a crucial compound in the field of organic synthesis. It has a wide range of uses and is mainly used in drug synthesis. In the process of drug development, this compound acts as a key intermediate, which can construct molecular structures with specific pharmacological activities through a series of chemical reactions, thereby helping to create new drugs and making great contributions to the medical industry.
Furthermore, in the field of pesticide synthesis, 2-chloro-5-cyano-3-methylpyridine also plays an important role. From this raw material, many high-efficiency and low-toxicity pesticide products can be prepared, which are used to control crop diseases and pests, ensure crop yield and quality, and are of great significance in agricultural production.
In addition, in the field of materials science, the compound may be used in the synthesis of some functional materials due to its unique chemical structure. By reacting with other substances, the material is endowed with special properties, such as conductivity and optical properties, which opens up new paths for the development of materials science.
In short, 2-chloro-5-cyano-3-methylpyridine has important uses in many fields such as drugs, pesticides and materials, and plays an indispensable role in promoting the development of related industries.

The synthesis of 2-chloro-5-cyano-3-methylpyridine has been known for a long time. The synthesis of this compound follows several common paths.
One of them can be started from suitable pyridine derivatives. Using a pyridine containing a specific substituent as the raw material, chlorine atoms are introduced by halogenation reaction. During halogenation, a suitable halogenating agent, such as a chlorine-containing reagent, is selected. Under specific reaction conditions, the chlorine atoms fall precisely at the designated position of the pyridine ring, that is, position 2. This reaction requires fine regulation of reaction temperature, time and ratio of reactants to achieve the best effect.
Then, the introduction of cyanyl groups is also a key step. Cyanide reagents are often used to react with halogenated pyridine derivatives. Cyanide reagents need to be carefully selected to consider their reactivity and selectivity. During the reaction process, the choice of solvent should not be underestimated, and different solvents have a great impact on the reaction rate and yield. After this step, the cyanyl group is connected to the 5th position of the pyridine ring.
Furthermore, there are also methods for the introduction of methyl groups. Methylation reagents can be used to successfully connect the pyridine ring to methyl groups at the 3rd position. Methylation reactions require specific catalysts to facilitate the smooth progress of the reaction. The type and amount of catalysts need to be precisely controlled.
In addition, there are other synthesis strategies. Or cyano and methyl can be introduced first, and then halogenated. This approach also requires careful planning of each step of the reaction to ensure that each substituent is connected in sequence and avoid unnecessary side reactions. After each step of the reaction, fine operations such as separation and purification are required to obtain high-purity 2-chloro-5-cyano-3-methyl pyridine. This synthesis process is like a craftsman, and every step needs to be precise to obtain this target compound.

2-Chloro-5-cyano-3-methylpyridine is a unique molecule in organic compounds. Its physical properties contain several ends, let me tell them one by one.
First appearance, this compound is often in the form of a white to off-white solid, just like the first snow in winter, pure and simple, or slightly shiny in the sun, as if concealing a mysterious light.
Besides the melting point, its melting point is usually within a specific temperature range. This temperature is similar to the "transformation point" of a substance. When the external temperature reaches near the melting point, the solid 2-chloro-5-cyano-3-methylpyridine will slowly transform from solid to liquid, like ice and snow melting, quietly changing its own form.
In terms of solubility, it shows unique solubility properties in some organic solvents. In organic solvents such as dichloromethane and chloroform, it can dissolve well, just like a fish getting water, and the molecules are evenly dispersed in it to form a uniform and stable system. However, in water, its solubility is relatively limited, just like the difficulty of oil and water, only a very small amount can interact with water.
Boiling point is also one of the important physical properties. At the boiling point, 2-chloro-5-cyano-3-methylpyridine in the liquid boils violently and becomes gaseous and dissipates. This boiling point value reflects the strength of its intermolecular forces and is also a key indicator of its state transition under specific conditions.
Above the density, 2-chloro-5-cyano-3-methylpyridine has its own specific density. This density allows it to follow the physical law when mixed with other substances, or sink or float, showing a unique physical behavior.
In addition, its stability is acceptable under normal conditions. When encountering external factors such as hot topics, open flames or strong oxidants, or triggering chemical reactions, the stability is broken, the molecular structure is changed, and new substances are derived, showing the wonderful changes in the chemical world. These physical properties constitute the unique "physical portrait" of 2-chloro-5-cyano-3-methylpyridine, which is of great significance in the field of organic chemistry and provides a key basis for scientific research, production and many other aspects.

2-Chloro-5-cyano-3-methylpyridine, an organic compound with unique chemical properties, has attracted much attention in the field of organic synthesis.
Its chemical properties bear the brunt of the substitution reaction. Because of its high activity of chlorine atoms, it is easy to initiate nucleophilic substitution when encountering nucleophiles. Such as in basic environments, hydroxyl, amino and other nucleophilic groups can replace chlorine atoms to form corresponding derivatives. This reaction mechanism is that nucleophilic testers attack chlorine-containing carbon atoms, and the chlorine atoms leave with a pair of electrons to form new chemical bonds. This substitution reaction lays the foundation for the construction of various pyridine derivatives and is widely used in the fields of medicinal chemistry and materials science.
Furthermore, cyanyl groups also endow the compound with rich reactivity. Cyanyl groups can be hydrolyzed and gradually converted into carboxylic groups under acidic or alkaline conditions. In acidic hydrolysis, cyanyl groups are protonated first, and then attacked by nucleophilic water molecules. After a series of intermediates, carboxylic acids are finally formed; in basic hydrolysis, hydroxyl ions attack cyanyl groups, which also generate carboxylic salts. In addition, cyanyl groups can also participate in nucleophilic addition reactions, combining with nucleophilic reagents such as alcohols and amines to form nitrile derivatives, which are used in organic synthesis to expand carbon chains and introduce new functional groups.
From the perspective of electronic effects, methyl as the power supply group will increase the electron cloud density of the pyridine ring, especially in the methyl ortho and para-sites. This not only affects the regioselectivity of the substitution reaction on the pyridine ring, but also makes the electrophilic substitution reaction more likely to occur in the methyl ortho and para-sites, but also affects the physical properties of the compound such as melting point and boiling point. Generally speaking, the power supply group will enhance the intermolecular force, which will increase the melting point and boiling point.
2-chloro-5-cyano-3-methylpyridine exhibits diverse chemical properties due to its synergistic effect of chlorine atom, cyano group and methyl group, providing many possibilities for organic synthesis chemists, making it widely used in many fields and becoming the focus compound of organic synthesis chemistry research.

I don't know the price range of 2-chloro-5-cyano-3-methylpyridine in the market. The price of these substances often varies for a variety of reasons. Its preparation is difficult and easy. If the preparation method is complicated, many steps are required, exquisite skills are required, and the raw materials are rare and difficult to find, the price will be high; if the preparation is relatively simple and the raw materials are easy to obtain, the price will be low.
Furthermore, the state of market supply and demand also affects its price. If many companies seek this compound for the research and development and manufacturing of medicines and pesticides, the demand is strong, and the supply is limited, the price will rise; if the demand is low and the supply is sufficient, the price will decline.
In addition, the location, scale and business strategy of the manufacturer also affect its price. Large factories may have an advantage in pricing due to economies of scale or production at a lower cost; small factories may have different pricing due to cost considerations. And the marketing strategies of each factory are different, and promotions, discounts, etc. also cause price fluctuations.
Because there is no detailed data on the current market, it is difficult to determine its price range. For details, you can consult chemical raw material suppliers, browse professional chemical product trading platforms, or refer to industry reports, so that you can get more accurate price information.