2-Chloro-5-(aminomethyl)-pyridine

2-Chloro-5- (aminomethyl) pyridine, an important organic compound, has critical uses in many fields.
First, in the field of drug synthesis, it is a key intermediate. It can be combined with other specific chemical structures through a series of chemical reactions to construct drug molecules with specific pharmacological activities. For example, when developing new drugs for specific disease targets, the special chemical structure of 2-chloro-5- (aminomethyl) pyridine can endow drug molecules with suitable spatial configuration and electronic properties, so that they can precisely act on the target and exert therapeutic effects.
Second, in the field of materials science, it also plays an important role. It can participate in the synthesis process of polymer materials, and introduce special functional groups to the material by polymerizing with other monomers, thereby improving the properties of the material. Such as enhancing the stability, solubility or endowing it with specific optical and electrical properties, it provides the possibility for the preparation of functional polymer materials.
Furthermore, in the basic research of organic synthetic chemistry, 2-chloro-5- (aminomethyl) pyridine is a common reagent for exploring new reaction pathways and reaction mechanisms. Due to the presence of chlorine atoms and aminomethyl groups in its structure, it can trigger various types of chemical reactions, providing rich research materials for organic chemists, helping to expand the methods and strategies of organic synthesis, and promoting the development of organic chemistry.
From this perspective, 2-chloro-5- (aminomethyl) pyridine, with its unique chemical structure, has shown value that cannot be ignored in the fields of drugs, materials and organic synthesis research, and has played a positive role in promoting the progress of many sciences and technologies.

2-Chloro-5- (aminomethyl) pyridine is one of the organic compounds. Its physical properties are crucial to the application and characteristics of this compound.
First of all, its appearance is mostly white to white-like crystalline powder at room temperature. This form is easy to identify, and it is very convenient for storage and use. Looking at its color, in its pure state, white to white characterization suggests its high purity and stability.
As for the melting point, it is within a specific temperature range. Determination of the melting point is an important means to identify this compound. Accurate melting point values help confirm its authenticity and purity. The melting point of the compound with different purity may vary slightly.
Solubility is also an important physical property. In common organic solvents, such as ethanol, dichloromethane, etc., it has a certain solubility. This property makes it possible to choose a suitable solvent in a chemical reaction to promote the progress of the reaction. In water, its solubility may be limited, but it is not absolutely insoluble. The difference in solubility varies depending on factors such as the polarity of the solvent.
Furthermore, its density is also a specific value. The size of the density is instructive in the separation and purification of substances. Knowing its density can help to choose a suitable separation method, such as centrifugation, extraction, etc.
In addition, 2-chloro-5- (aminomethyl) pyridine has a certain degree of volatility. Although the volatility is not extremely high, it still needs to be paid attention to under certain conditions. Its volatility may be affected by factors such as temperature and pressure.
In general, the physical properties of 2-chloro-5- (aminomethyl) pyridine, such as appearance, melting point, solubility, density and volatility, are interrelated and play an important role in many fields such as organic synthesis and drug development. In practical applications, it is necessary to carefully consider its various physical properties in order to achieve the best effect.

The synthesis of 2-chloro-5- (aminomethyl) pyridine has been studied by many scholars in the past, and now I will describe it in detail.
One method can be started from 2-chloro-5-methylpyridine. First, under appropriate reaction conditions, 5-methylpyridine is partially oxidized to the corresponding carboxylic acid with a suitable oxidizing agent, such as potassium permanganate or potassium dichromate. This step requires temperature control and time control to prevent excessive oxidation. Next, the carboxylic acid is converted to acyl chloride with chlorinated reagents such as dichlorosulfoxide or oxalyl chloride. This acid chloride is reacted with excess ammonia or ammonia in suitable solvents, such as dichloromethane and tetrahydrofuran, to obtain the target product 2-chloro-5- (aminomethyl) pyridine.
The second method can be started from 2-chloro-5-bromomethylpyridine. The reaction is heated with a suitable aminating agent, such as phthalimide potassium salt, in a polar solvent, such as N, N-dimethylformamide, and nucleophilic substitution is used to obtain 2-chloro-5- (phthalimidomethyl) pyridine. 2-Chloro-5- (aminomethyl) pyridine can also be obtained by refluxing with hydrazine hydrate and other reagents in an alcohol solvent to remove phthalyl groups.
The third method is to use 2-chloro-5-cyanopyridine as a raw material. In the presence of a suitable catalyst, such as Raney nickel, hydrogen is used as a reducing agent, and in an alcohol solvent, under appropriate temperature and pressure, the cyano group can be reduced to aminomethyl groups to obtain 2-chloro-5- (aminomethyl) pyridine.
The above synthesis methods have their own advantages and disadvantages, and the selection needs to be weighed according to the actual required raw materials, reaction conditions and product purity in order to achieve the best synthesis effect.

2-Chloro-5- (aminomethyl) pyridine is an important intermediate in organic synthesis. During storage and transportation, special attention should be paid to many matters.
When storing, the first choice of environment. It should be placed in a cool and ventilated place, because the substance is easy to decompose or cause other chemical reactions when heated. If the ambient temperature is too high, it may deteriorate and affect the effect of subsequent use. And it needs to be kept away from fire and heat sources. Open flames and high temperatures are hidden dangers, and it is easy to cause serious accidents such as fires and even explosions.
Furthermore, the storage place should be kept dry. This substance has a certain water absorption. If it is damp, it may react with water, resulting in a decrease in purity. Therefore, the humidity in the warehouse must be properly controlled, and the environment can be maintained dry by auxiliary means such as desiccants.
At the same time, it needs to be stored separately from oxidants, acids and other substances. Due to its active chemical nature, contact with these substances is very likely to cause violent chemical reactions, endangering storage safety.
When transporting, the packaging must be solid and reliable. Packaging materials that meet relevant standards should be used to prevent the packaging from being damaged due to collisions, vibrations, etc. during transportation, which may lead to material leakage. Once leaked, not only will it cause losses, but it may also pose a threat to the environment and personnel safety.
Transportation vehicles should also be carefully selected and inspected. Vehicles should have good ventilation conditions to avoid the formation of flammable and explosive atmospheres in the transportation space. And the transportation equipment needs to be well grounded to prevent the accumulation of static electricity from causing danger.
Transportation personnel should also be familiar with the characteristics of the substance and emergency treatment methods. If there is an emergency on the way, such as leakage, etc., measures can be taken quickly and correctly to reduce the degree of harm.
In short, the storage and transportation of 2-chloro-5- (aminomethyl) pyridine cannot be ignored. Only by strictly complying with relevant regulations and operating procedures can its safety be ensured.

2-Chloro-5- (aminomethyl) pyridine, the price of this product in the market is difficult to determine. The price often varies due to many reasons, such as the amount of production, the quality of the quality, the prosperity of the demand, the change of time, and the complexity and simplicity of the production, the distance of the transportation, and the increase or decrease of the tax.
In the past, if the demand for this product exceeded the supply, the price would rise; in case of abundant production and lack of demand, the price would decline. The purity of its quality is also the key to the price. Those who are of high quality will have a higher price than those who are of poor quality. And the distance of the origin and the smooth transportation are related to the cost, which also makes the price different. < Br >
If you want to know the exact price, you should consult the broker of chemical raw materials, the broker of market change, or the trading platform and market newspaper of chemical materials. In this way, you can get the right price at the time, so as not to be mistaken by false numbers, so as to meet the actual needs and make good progress in trade.