2-Chloro-4-pyridinecarboxylic acid 1,1-dimethylethyl ester

2-Chloro-4-pyridinecarboxylic acid 1,1-dimethyl ethyl ester, its physical properties are as follows. This substance is mostly solid at room temperature, and it appears to be white to off-white crystalline powder. This form is conducive to storage and use, and the texture of the powder is fine, indicating that its crystallization is good.
When it comes to the melting point, it is about a specific temperature range. This temperature range is of great significance for defining the purity of the substance and subsequent processing operations. The accurate determination of the melting point can provide a key basis for judging its quality.
In terms of solubility, it has certain solubility in common organic solvents such as ethanol and acetone. In ethanol, with the increase of temperature, the dissolution rate is accelerated, and the solubility also increases, which is convenient for the application of this substance in the reaction system using ethanol as the solvent. In acetone, it can dissolve quickly to form a uniform solution, creating convenient conditions for various chemical synthesis or analytical testing involving acetone solvents. However, in water, its solubility is very small, which is related to the molecular structure and polarity of the substance. The hydrophobic groups contained in the molecule make it difficult to dissolve in the polar aqueous phase.
Density is also one of its important physical properties and has a specific value. This density value needs to be taken into account when dealing with the separation and mixing of substances. For example, in the liquid-liquid extraction process, the density difference is related to the stratification status and affects the separation effect.
In addition, the substance has a certain stability. Under normal temperature, humidity and light conditions, the chemical structure does not change significantly for a period of time. However, in high temperature, high humidity or strong light environments, the stability will be affected, and decomposition or other chemical reactions may occur, causing changes in its physical properties.

To prepare 1,1-dimethyl ethyl 2-chloro-4-pyridinecarboxylic acid, there are three methods.
First, take 1, 1-dimethyl ethyl 4-pyridinecarboxylic acid as the starting material and pre-halogenate it. In a suitable reaction bottle, add 1, 1-dimethyl ethyl 4-pyridinecarboxylic acid and dissolve it with an appropriate amount of inert solvent, such as dichloromethane. Cold to an appropriate temperature, or about 0 ° C, slowly add a halogenating agent, such as N-chlorosuccinimide (NCS), and add an initiator, such as azobisisobutyronitrile (AIBN). Under mild heating or light conditions, the halogenation reaction can begin. After the reaction is completed, it can be separated and purified by conventional method, washed with water, dried, column chromatography, etc., to obtain 1,1-dimethyl ethyl 2-chloro-4-pyridinecarboxylic acid.
Second, use 2-chloro-4-pyridinecarboxylic acid as raw material to form an ester with 1,1-dimethyl ethanol (tert-butyl alcohol). In the reaction vessel, add 2-chloro-4-pyridinecarboxylic acid, tert-butyl alcohol, and use acid as catalyst, such as concentrated sulfuric acid or p-toluenesulfonic acid. Heat to appropriate temperature, or 80-100 ℃, for several times of reaction. After the reaction is completed, it is cooled, poured into ice water, and extracted with an organic reagent, such as ether. The extraction solution is washed, dried, and distilled to obtain the target product in addition to the solvent and unreacted raw materials.
Third, react with sodium tert-butyl alcohol with 2-chloro-4-pyridinoyl chloride. First, 2-chloro-4-pyridinoyl chloride is prepared, and 2-chloro-4-pyridinoyl carboxylic acid is reacted with a chlorinated reagent, such as dichlorosulfoxide, under appropriate conditions. Then, 2-chloro-4-pyridinoyl chloride is taken and dissolved in an anhydrous solvent, such as tetrahydrofuran. Cold to low temperature, such as - 10 ℃ to 0 ℃, slowly add sodium tert-butanol solution. After the reaction, after post-treatment, such as quenching with water, extraction, drying, column chromatography, 2-chloro-4-pyridine carboxylic acid 1,1-dimethyl ethyl ester can be obtained.

2-Chloro-4-pyridinecarboxylic acid 1,1-dimethyl ethyl ester, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its pyridine ring and specific ester structure, it can participate in a variety of chemical reactions, such as nucleophilic substitution reactions. In nucleophilic substitution, chlorine atoms have good activity and can be replaced by various nucleophilic reagents to form novel carbon-heteroatom bonds, and then synthesize compounds with unique structures and properties, which is of great significance in the creation of new drug molecules or functional materials.
In the field of pharmaceutical chemistry, this is used as a starting material, modified by a series of reactions, or can produce lead compounds with biological activity. Pyridine rings are commonly found in many drug structures and have a significant impact on the interaction between drugs and targets; while ester groups can improve the lipid solubility of compounds and affect their pharmacokinetic properties such as absorption and distribution in vivo. For example, after specific modifications, therapeutic drugs for specific diseases (such as inflammation, tumors and other related targets) may be developed.
In the field of materials science, through its participation in polymerization reactions or coupling with other functional molecules, or materials with special properties can be prepared. For example, in the synthesis of some functional polymers, it is introduced as a structural unit to endow polymers with specific chemical and physical properties, such as the ability to recognize and respond to specific substances, so it can be used in sensor materials, separation materials and other fields.

2-Chloro-4-pyridinecarboxylic acid-1,1-dimethyl ethyl ester, when hiding, many matters need to be paid attention to. This is an organic compound, which is sexual or active, so it must be placed in a cool, dry and well ventilated place. Avoid direct sunlight, sunlight can promote its chemical reaction, resulting in quality changes.
Furthermore, it must not be mixed with oxidants, acids, bases and other substances. When this compound encounters such substances, it may react violently and cause dangerous conditions, such as explosion, fire, etc. It is also necessary to store it in a closed container to prevent it from evaporating, and to avoid excessive contact with the air, due to moisture, oxygen, etc. in the air, or the effect of it.
Also, the storage place should be clearly marked, stating the name, nature and attention of the thing, so that the person who takes it and manages it can see it at a glance, so as not to be wrong. And regularly check its storage status to see if the package is damaged or deteriorated. If there is any abnormality, dispose of it quickly to ensure its safety. In this way, it must be properly preserved to avoid accidents.

I look at your question, and I am inquiring about the market price of 2-chloro-4-pyridinecarboxylic acid 1,1-dimethyl ethyl ester. However, it is not easy to know the price of this product. The market price is influenced by many factors, which are like changes in the wind and clouds, and it is difficult to determine.
First, the supply and demand situation of this product has a huge impact on the price. If the market demand is strong and the supply is short, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall. Second, the cost of producing this product is also the key. The price of raw materials, the complexity of the preparation process, and the cost of labor will all make the cost different, which will then affect the price.
Furthermore, the prices of different markets in different regions may also vary. Economically developed places, or due to factors such as transportation, taxes, market competition, etc., the prices are different from others. And the prices set by different suppliers are also different. Each supplier has its own price due to its own cost control and market strategies.
Because there is no exact information, it is difficult to inform its specific price. To get an accurate price, you can consult the chemical product trading platform, relevant suppliers, or in the chemical industry information to get a more accurate market price.