2-Chloro-4-methylpyridine-5-boronic acid

2-Chloro-4-methylpyridine-5-boronic acid, this compound has unique chemical properties. It contains specific structures such as boron, chlorine, and pyridine rings, which endow it with various reactivity.
From the structural point of view, the pyridine ring is aromatic, and the electron cloud distribution on the ring is unique, so that the compound can participate in a variety of electrophilic and nucleophilic reactions. Boron atoms are in the + 3 oxidation state, and boric acid groups can undergo esterification, dehydration and other reactions. They are often used as key intermediates in organic synthesis. By coupling reactions with halogenated hydrocarbons, carbon-carbon bonds are formed to synthesize complex organic molecules.
Chlorine atoms at specific positions in the pyridine ring affect the density of cyclic electron clouds and change their reactivity and selectivity. In nucleophilic substitution reactions, chlorine atoms can be replaced by a variety of nucleophilic reagents, introducing different functional groups to expand the structural diversity of compounds. The existence of
4-methyl adds steric hindrance and electronic effects to molecules, affects intermolecular interactions, and plays an important role in reaction pathways and product configurations.
Its physical properties are mostly solid at room temperature. Due to the formation of hydrogen bonds by boric acid groups, the melting point and boiling point are affected, and it exhibits certain solubility in water and some organic solvents, which provides convenience for its separation and purification in synthesis operations.
Overall, 2-chloro-4-methylpyridine-5-boronic acid, with its special structure, plays an important role in the fields of organic synthesis, medicinal chemistry, etc., with its rich and diverse reactivity and unique physical properties, which can help chemists create novel and valuable organic compounds.

The common synthesis methods of 2-chloro-4-methylpyridine-5-boronic acid cover the following.
First, halopyridine is used as the starting material. First, take the appropriate halopyridine, such as 2-chloro-4-methyl-5-halopyridine, and interact with metal reagents, such as n-butyl lithium, to form a lithium intermediate. This intermediate is highly active, and then reacts with borate esters, such as trimethyl borate, and through hydrolysis steps, 2-chloro-4-methylpyridine-5-boronic acid can be obtained. In this process, the reaction conditions between metal reagents and halogenated pyridine need to be carefully regulated, such as reaction temperature, time, and reagent ratio, which all have a great impact on the formation of the product.
Second, the direct boration of pyridine derivatives is used. Select the appropriate 2-chloro-4-methylpyridine derivative and react with boronation reagents, such as pinacol diborate, in the presence of appropriate catalysts, such as transition metal catalysts, such as palladium catalysts. This reaction requires specific ligand assistance to enhance catalyst activity and selectivity. The factors such as the solvent, the type and dosage of the base in the reaction system also need to be carefully considered, so as to effectively promote the progress of the boration reaction and achieve the synthesis of the target product.
Third, the construction of the pyridine ring is carried out synchronously or step by step with the boration. The structure of the pyridine ring is constructed first, and the boron group is introduced during or after the construction process. For example, through a suitable nitrogen-containing and carbon-containing raw material, the pyridine ring is formed by cyclization reaction, and then the specific position of the pyridine ring is boronized. This path requires precise control of the reaction conditions of each step of the pyridine ring construction and boration to obtain the ideal synthesis effect.

2-Chloro-4-methylpyridine-5-boronic acid, this compound is useful in many fields such as pharmaceutical synthesis and material chemistry.
In the field of pharmaceutical synthesis, it is often a key intermediate. The structure of Geinpyridine and boric acid gives it unique reactivity and selectivity. It can be coupled with halogenated aromatics or olefins through Suzuki-Miyaura coupling reaction to form various carbon-carbon bonds and synthesize complex molecules with biological activity. For example, when developing new antibacterial and anti-tumor drugs, it can be used to participate in the reaction to build a specific molecular framework, laying the foundation for drug activity and selectivity. < Br >
In the field of material chemistry, because it contains pyridine rings and boric acid groups, it can participate in the process of material self-assembly and cross-linking. Pyridine rings can coordinate with metal ions to form stable complexes for the preparation of functional metal-organic framework materials (MOFs), which are excellent in gas adsorption, separation and catalysis. Boric acid groups can reversibly react with hydroxyl-containing compounds such as polyols and sugars. According to this property, smart materials that respond to specific substances can be prepared, which has great potential in the field of sensors. In addition, in organic synthetic chemistry, as an important organoboron reagent, it can participate in the design of various novel reaction paths, opening up new paths for the synthesis of organic compounds with unique structures and promoting the development of organic synthesis methodologies.

2-Chloro-4-methylpyridine-5-boronic acid, the price of this product in the market is difficult to determine. The price of the cover often changes for many reasons.
First, the price of raw materials has a great impact. If the raw materials required for the production of this acid are rare in source, or due to the weather, geographical conditions, and human factors, the supply is unstable, and the price also fluctuates. If the price of raw materials is high, the cost of this acid will increase, and the price of the acid will rise in the market. If the raw materials are easily available and the price is flat, the cost can be reduced, and the price may also decrease.
Second, the method of preparation is related to cost and output. Sophisticated methods can make the output efficient, with less impurities, and the cost can be controlled, and the price is close to the people; if the method is not sufficient, the output is low and there are many impurities, the cost is high, and the price will tend to be high.
Third, the supply and demand of the city is the key. If there are many users, the demand is greater than the supply, and the merchant will make a profit, the price will rise; if there is a shortage of demand, the supply will exceed the demand, and the price will be reduced for promotion.
Fourth, the difference between manufacturers is also related. Large manufacturers have the benefit of scale, the cost can be pressed, and the price may have an advantage; small manufacturers, due to the limited scale, the cost is difficult to reduce, and the price may be high.
Looking at past market conditions, the price of this acid per gram may range from tens to hundreds of yuan. However, this is only a rough estimate. To know the exact price, you need to consult the chemical raw material supplier and observe the price in detail according to the current situation.

2-Chloro-4-methylpyridine-5-boronic acid is a commonly used reagent in organic synthesis. Its storage conditions are very important, which are related to the stability of its chemical properties and the effect of subsequent use.
This reagent should be stored in a dry and cool place. A dry environment can avoid contact with water vapor. Capping water vapor can easily initiate hydrolysis reactions and cause deterioration of the reagent. If too much moisture is absorbed, the boric acid group may be damaged, thereby damaging the activity of the reagent and difficult to achieve the desired effect in the synthesis reaction.
Cool conditions are also indispensable. High temperatures accelerate the rate of chemical reactions, causing unnecessary decomposition or polymerization of 2-chloro-4-methylpyridine-5-boronic acid. When the temperature is too high, the thermal motion of the molecule intensifies, and the stability of its structure decreases, which in turn affects the purity and performance of the reagent.
In addition, the reagent should be sealed when stored. Sealing can prevent it from coming into contact with gases such as oxygen and carbon dioxide in the air. Oxygen may oxidize it, and carbon dioxide may react with some of the groups in it, which can change the chemical composition of the reagent and cause it to lose its original reactivity.
In summary, 2-chloro-4-methylpyridine-5-boronic acid should be stored in a dry, cool, and sealed environment to maintain its chemical stability and ensure its effectiveness in organic synthesis experiments.