2-Chloro-4-iodo-6-trifluoromethyl-pyridine

2-Chloro-4-iodine-6-trifluoromethyl pyridine, which is widely used. In the field of pharmaceutical synthesis, it is often a key intermediate. The special structure of the gainpyridine ring gives the compound unique chemical properties, which can be modified by chemical reaction to obtain substances with specific pharmacological activities. It is often used in the development of antibacterial, antiviral, antitumor and other drugs.
It also plays an important role in the creation of pesticides. With its halogen atom and trifluoromethyl, it can improve the biological activity and environmental stability of the compound against pests and bacteria. By ingeniously designing and synthesizing, high-efficiency, low-toxicity and environmentally friendly pesticides can be prepared, which can help agricultural pest control and ensure crop harvest.
Furthermore, in the field of materials science, it may participate in the preparation of special functional materials. Due to molecular structure characteristics, after specific processing, it may endow materials with unique properties such as photoelectric properties and thermal stability, and have potential applications in organic optoelectronic materials, high-performance polymers and other fields.
In summary, 2-chloro-4-iodine-6-trifluoromethylpyridine is an indispensable and important compound in many fields such as medicine, pesticides and materials science, promoting the development and progress of related fields.

There are several common methods for synthesizing 2-chloro-4-iodine-6-trifluoromethyl pyridine. First, chlorine and iodine atoms can be introduced by halogenation reaction from compounds containing pyridine rings, and then trifluoromethyl can be introduced by specific reagents. For example, using 2-chloro-6-methylpyridine as the starting material, first using an iodine substitution reagent, under appropriate reaction conditions, such as in a catalyst and a specific solvent, the methyl ortho-iodine reaction occurs to generate 2-chloro-4-iodine-6-methylpyridine; then using a trifluoromethylation reagent, at a suitable reaction temperature and a base, the methyl group is converted to trifluoromethyl group, and the final product is obtained.
Second, you can also start with a pyridine derivative, introduce trifluoromethyl group first, and then carry out a halogenation reaction. For example, 2-methyl-6-trifluoromethylpyridine is first prepared, and chlorination reactions are carried out under suitable conditions to introduce chlorine atoms at the methyl ortho-position; then iodine atoms are introduced at another ortho-position through iodine reactions to synthesize 2-chloro-4-iodine-6-trifluoromethylpyridine.
Furthermore, the strategy of gradually constructing pyridine rings can also be adopted. Using small molecules containing corresponding substituents as raw materials, pyridine rings are constructed through a series of reactions such as condensation and cyclization, and chlorine, iodine and trifluoromethyl are introduced at the same time. For example, with suitable fluorine, chlorine, iodine-substituted enamines and nitriles, under acidic or basic catalysis, cyclization occurs to form pyridine rings, and then obtain the target product. This method requires precise control of the reaction conditions to ensure the correct introduction of each substituent and the smooth construction of the pyridine ring. During the synthesis process, the reaction conditions such as temperature, solvent, catalyst and other factors need to be carefully regulated to improve the yield and purity of the target product.

2-Chloro-4-iodine-6-trifluoromethylpyridine, this is an organic compound with unique physical properties.
It is mostly solid at room temperature, due to its intermolecular forces and structural properties. The melting point is a specific value. When it reaches this temperature, the substance gradually melts from the solid state to the liquid state. This temperature is a key indicator to measure its stability and phase transition.
The boiling point is also an important physical property. At this temperature, the compound is violently vaporized from a liquid state to a gaseous state. The boiling point is affected by factors such as intermolecular forces, molecular weight and molecular structure.
In terms of solubility, in organic solvents, such as common ethanol, ether, etc., due to the principle of similar miscibility, some organic solvents are similar to 2-chloro-4-iodine-6-trifluoromethyl pyridine in molecular structure, polarity matching, so soluble; in water, because of its chlorine, iodine, trifluoromethyl and other hydrophobic groups, the polarity is different from water, and the solubility is poor.
Density is the mass per unit volume. The density of this compound has a specific value. In practical applications, such as separation and mixing processes, the density difference can be used to design separation schemes.
In addition, the appearance may be white to pale yellow crystalline powder, and this color and morphology are determined by molecular arrangement, crystal structure, and absorption and reflection characteristics of light.
Its vapor pressure is also an important characteristic, which characterizes the partial pressure trend of compounds in the gas phase at a certain temperature, which has an important impact on their behavior and reactivity in the gas phase.
In summary, the melting point, boiling point, solubility, density, appearance, and vapor pressure of 2-chloro-4-iodine-6-trifluoromethylpyridine are of great significance for their applications in chemical synthesis, industrial production, analysis and testing.

2-Chloro-4-iodine-6-trifluoromethylpyridine is a special pyridine derivative in organic chemicals. Its chemical properties are unique, and its chemical behavior is affected by the chlorine atom, iodine atom and trifluoromethyl in its structure.
First of all, its halogen atom properties. Both chlorine and iodine atoms are halogen elements, which give the compound the activity of nucleophilic substitution reaction. Although chlorine atoms have high electronegativity, due to their small atomic radius, they can be replaced by nucleophilic reagents as leaving groups in nucleophilic substitution reactions. Although the electronegativity of the iodine atom is slightly inferior to that of chlorine, its atomic radius is large, the C-I bond energy is relatively low, and it is more prone to heterocleavage, making this position an excellent check point for nucleophilic substitution reactions. Therefore, when encountering nucleophilic reagents such as alkoxides and amines, the position of the halogen atom is prone to substitution, forming new carbon-heteroatom bonds, thereby constructing a variety of organic compounds.
Looking at trifluoromethyl again. This group has strong electron absorption. Due to the high electronegativity of the fluorine atom, trifluoromethyl becomes a strong-pulling electron group. Its existence reduces the electron cloud density of the pyridine ring, especially the ortho and para-positions, resulting in a decrease in the activity of the electrophilic substitution But at the same time, the electron-withdrawing action enhances the tendency of the halogen atom to leave, making the nucleophilic substitution reaction easier to proceed. Moreover, the presence of trifluoromethyl groups significantly changes the physical properties of the molecule, such as increasing the lipid solubility of the compound, affecting its solubility and partition coefficient in different solvents.
In addition, 2-chloro-4-iodine-6-trifluoromethyl pyridine has a certain polarity due to its asymmetric structure. This polarity affects the intermolecular forces and also affects the physical properties such as melting point and boiling point. And due to the presence of halogen atoms and trifluoromethyl, the compound may have certain chemical stability, but under certain conditions, such as high temperature, strong acid and strong base or strong oxidant, chemical reactions may still occur, or cause changes in the structure of pyridine rings, or the transformation of substituents. In short, the chemical properties of this compound are rich and diverse, and it has broad application prospects in the field of organic synthesis.

I have not heard the exact price range of 2-chloro-4-iodine-6-trifluoromethylpyridine on the market. However, if you want to know its price, you can follow various ways.
First, ask the intercity chemical material supplier or supplier. The pricing of various suppliers may vary depending on the source, quantity, and season. If the quantity is large, you may get a good price; and when the goods are thin, the price may rise.
Second, the chemical trading website, which often has information on the price of materials. The prices listed by various merchants can be widely compared to clarify their approximate price range.
Third, ask people in the chemical industry. Experts may be able to tell the price trend and approximate range of this material in the near future based on their experience and communication.
If you want to get an accurate price, you still need to consult the supplier in person, and the current market conditions shall prevail. The market for chemical materials is constantly changing, and raw material costs, supply and demand trends, policies and regulations can all make prices fluctuate.