2-[chloro(4-chlorophenyl)methyl]pyridine

2-%5Bchloro%284-chlorophenyl%29methyl%5Dpyridine, the Chinese name is often called 2- [chloro (4-chlorophenyl) methyl] pyridine. This substance has a wide range of uses and is often used as a key intermediate in the field of organic synthesis. Due to its unique chemical structure, many different types of compounds can be derived through various chemical reactions.
In the field of pharmaceutical chemistry, this is used as a starting material to prepare drug molecules with specific biological activities through multi-step reactions. For example, some studies have tried to construct it into a specific heterocyclic system to explore innovative drugs that have inhibitory or regulatory effects on certain disease targets. In the field of pesticide research and development, it also shows potential value. It can be modified and converted into compounds with insecticidal, bactericidal or herbicidal activities. For example, by introducing specific functional groups, changing their lipophilicity, electron cloud distribution, etc., to optimize the effect on specific pests or pathogens, and lay the foundation for the development of new high-efficiency and low-toxicity pesticides.
In the field of materials science, 2 - [chloro (4-chlorophenyl) methyl] pyridine is also involved. In the preparation of some functional materials, it can participate in the polymerization reaction as a structural unit, giving the material unique optical, electrical or mechanical properties. For example, in the synthesis of some organic optoelectronic materials, the introduction of this structure can adjust the charge transfer performance and luminous efficiency of the material, providing a new direction for the development of new optoelectronic materials.

2-%5Bchloro%284-chlorophenyl%29methyl%5Dpyridine, this is an organic compound, often chemically synthesized. Its physical properties are related to many aspects, let me talk about them one by one.
When it comes to appearance, under normal temperature and pressure, it is mostly colorless to light yellow liquid form, or white to white solid, but the exact appearance often varies according to purity and crystallization.
Looking at its melting point, due to the interaction of benzene ring, pyridine ring and chlorine atom in the molecular structure, the intermolecular force is complicated, so the melting point is quite high. Specifically, in a specific numerical range, this melting point value is a key indicator to determine the purity and characteristics of the compound.
In terms of boiling point, there are van der Waals forces and dipole-dipole interactions between molecules, resulting in a certain range of boiling points. When the temperature rises to the boiling point, the compound changes from liquid to gaseous state. This process requires external energy supply to overcome intermolecular forces.
Solubility is also an important physical property. The compound exhibits good solubility in organic solvents, such as ethanol, acetone, dichloromethane, etc. Because the molecular structure contains lipophilic groups, it can form van der Waals forces or other weak interactions with organic solvent molecules, so that it can be uniformly dispersed in organic solvents. However, due to poor solubility in water, its polar molecules are not enough to form strong hydrogen bonds with water molecules.
In addition, density is also one of its physical properties. Due to the type and arrangement of atoms in the molecule, its density is different from that of water and other common solvents. This density property is of great significance for the calculation and operation of materials in separation, purification and related chemical reactions.
As for the refractive index, its molecular structure affects the propagation of light, resulting in a specific refractive index. This property can be used to identify and characterize this compound in optical materials or in the field of light propagation and interaction.

2 - [Chloro (4-chlorophenyl) methyl] pyridine, this is an organic compound. Its chemical properties are unique and valuable for investigation.
From the structural point of view, the compound contains a pyridine ring, and the second position of the pyridine ring is connected to the [chloro (4-chlorophenyl) methyl] group. The pyridine ring is aromatic, and the presence of nitrogen atoms gives it a certain alkalinity. Because there are lone pairs of electrons on the nitrogen atom, it can bind with protons and form pyridine salts in an acidic environment.
The halogenated benzyl structure of the compound makes the halogen atom have certain reactivity. Chlorine atoms can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, the nucleophilic reagents attack the carbon atoms connected to the chlorine atoms, and the chlorine atoms leave with a pair of electrons to form new compounds. For example, when reacted with sodium alcohol, corresponding ether compounds can be formed; when reacted with ammonia or amines, nitrogen-containing substitution products can be obtained.
And because of its benzene ring structure, the benzene ring is also aromatic and can undergo electrophilic substitution reactions such as electrophilic substitution reactions. Under suitable conditions, groups such as nitro and sulfonic acid groups can be introduced into the benzene ring. And due to the substitution of chlorine atoms on the benzene ring, its electronic effect will affect the activity and localization of The inducing effect of the ortho and para-position chlorine atoms is electron-absorbing, and the conjugation effect is electron-supplying. Under the combined action, the electrophilic substitution activity of the benzene ring is slightly lower than that of benzene, and the newly introduced group mainly enters the adjacent and para-position of the chlorine atom.
In addition, different groups in the molecule of the compound interact with each other, or their chemical properties are more complex. In the field of organic synthesis, it can be used as an important intermediate for the construction of organic compounds with more complex structures.

To prepare 2 - [chloro (4 - chlorophenyl) methyl] pyridine, you can do it as follows.
First take an appropriate amount of pyridine, place it in a reactor, cool it at low temperature, and reduce the temperature to about 0 ° C. Under this low temperature environment, slowly add a reagent containing chloro (4 - chlorophenyl) methyl. This reagent can also be prepared by method. 4-chlorobenzaldehyde can be reacted with chlorinating agents such as thionyl chloride to obtain 4-chlorobenzoyl chloride, and then 4-chlorobenzoyl chloride can be reduced at low temperature with appropriate reducing agents such as lithium aluminum hydride, and then reacted with chlorinating reagents such as hydrochloric acid to obtain chlorine (4-chlorophenyl) methyl chloride.
The dropwise addition process must be slow and stirred continuously to make the reactants fully contact. After the dropwise addition, slowly raise to room temperature, and then raise to an appropriate reaction temperature, between about 50 ° C and 70 ° C. When the reaction is continued at this temperature, the reaction process can be closely monitored during this period, which can be observed by means of thin layer chromatography. < Br >
When the reaction is almost complete, extract the reaction mixture with a suitable organic solvent such as dichloromethane to separate the organic phase. The organic phase is washed successively with water, sodium bicarbonate solution, and salt water to remove impurities. After washing, the organic phase is dried with anhydrous sodium sulfate, filtered, and the filtrate is distilled under reduced pressure to remove the organic solvent to obtain a crude product.
The crude product is refined by column chromatography or recrystallization to obtain pure 2- [chloro (4-chlorophenyl) methyl] pyridine. Appropriate silica gel is selected as the stationary phase by column chromatography, and the mixture of n-hexane-ethyl acetate is used as the mobile phase. The ratio is adjusted according to the polarity of the product. The recrystallization method selects an appropriate solvent, such as ethanol-water mixed solvent, heats to dissolve the crude product, filters it while it is hot, cools the filtrate to crystallize, filters it and dries it to obtain the refined product.

I have not heard the exact price of "2 - [chloro (4 - chlorophenyl) methyl] pyridine" in the market. The price of this compound may also change due to the difficulty of preparation and the difference in demand. If you want its price, you should find it in the market and business networks of chemical raw materials.
The price of chemical products often depends on the price of raw materials, the simplicity of the process, and the balance of supply and demand. This "2 - [chloro (4 - chlorophenyl) methyl] pyridine", if the raw materials are easy to obtain, the preparation method is simple, and there are not many people, the price is low; on the contrary, if the raw materials are rare, the production method is complicated, and there are many people who need it, the price will be high.
However, I have not been personally involved in this industry, so I cannot determine the exact price. To know more, you can visit the person of chemical materials, or check the price list on the website of chemical trading. In this way, you can get an approximate price of its recent price. Although the price range cannot be determined, it may be possible to find out one or two by following this route.