2-Chloro-3-Pyridine Carboxylic

2-Chloro-3-pyridinecarboxylic acid, which has a wide range of uses. In the field of medicine, it is an important organic synthesis intermediate and is often a key raw material for the preparation of various drugs. For example, the synthesis of some antibacterial drugs and nervous system drugs depends on its participation. Its structural properties endow drugs with specific biological activities and pharmacological functions, which are of great significance for drug development.
In the field of pesticides, 2-chloro-3-pyridinecarboxylic acid also plays an important role. It can be used to synthesize pesticides with high insecticidal and bactericidal properties. Because it can have a specific impact on the physiological process of pests, it can achieve good control effects, help agricultural production, and improve crop yield and quality.
In addition, in the field of materials science, 2-chloro-3-pyridinecarboxylic acid is also used. It can be used as a starting material for the construction of special functional materials, participate in the synthesis of materials with unique optical, electrical or mechanical properties, and have applications in electronic devices, optical instruments, etc., to promote the development and innovation of materials science. In short, 2-chloro-3-pyridinecarboxylic acid is of great value in many fields and plays an indispensable role in the progress of various industries.

2-Chloro-3-pyridinecarboxylic acid, which is a white to pale yellow crystalline powder. Its melting point is quite high, between 150 ° C and 154 ° C. This property makes it begin to change its phase at a specific temperature.
In terms of solubility, its solubility in water is limited, but it has better solubility in organic solvents such as ethanol and acetone. This difference in solubility is of great significance in many processes such as separation, purification and preparation.
Furthermore, 2-chloro-3-pyridinecarboxylic acid has a certain stability and can be stored for a long time under conventional temperature and humidity conditions without easy deterioration. However, in case of strong oxidizing agents, strong bases and other chemicals, chemical reactions will also occur, causing changes in its chemical structure.
Because of the presence of chlorine atoms, pyridine rings and carboxyl groups in its chemical structure, it has unique chemical activity. This activity makes it a significant position in the field of organic synthesis and is often used as a key intermediate for the preparation of various drugs, pesticides and functional materials. In conclusion, the physical properties of 2-chloro-3-pyridinecarboxylic acid play a crucial role in determining its application in different fields.

2-Chloro-3-pyridinecarboxylic acid, its chemical properties are quite stable at room temperature. This compound contains chlorine atoms, pyridine rings and carboxyl groups. Due to its special structure, it has its unique chemical performance.
In terms of stability, the pyridine ring is aromatic, giving the substance a certain stability. Its conjugate system can disperse electrons, reduce the molecular energy, and stabilize the structure. And although the carboxyl group has a certain reactivity, in the general environment, without specific reagents and conditions, it is not easy to spontaneously produce violent reactions.
However, under certain conditions, it will exhibit different chemical activities. When encountering strong oxidants, it may be oxidized because it contains carbon and hydrogen. In the nucleophilic substitution reaction, or as a leaving group, the chlorine atom reacts with the nucleophilic reagent and is replaced by other groups. Carboxyl groups can participate in the esterification reaction and form corresponding esters with alcohols under acid catalysis.
But in general, in the conventional environment, such as room temperature and pressure, without special chemical effects, 2-chloro-3-pyridinecarboxylic acid is chemically stable, does not easily change significantly, and can maintain its own chemical structure and characteristics.

The preparation method of 2-chloro-3-pyridinecarboxylic acid has been studied by the academic community throughout the ages, and the methods are various. Today, it is Jun Chen Qiyi.
First, 3-pyridinecarboxylic acid is used as the starting material, which is the foundation for preparation. Place 3-pyridinecarboxylic acid in a suitable reactor, which needs to be clean and chemically resistant. Then add an appropriate amount of solvent, such as glacial acetic acid. Glacial acetic acid is not only the reaction medium, but also promotes the progress of the reaction, so that the reactants can be fully contacted and fused.
Then slowly add chlorinated reagents, such as phosphorus oxychloride. When adding, you need to operate carefully and control the speed to prevent overreaction. Phosphorus oxychloride plays an important role in chlorination in the reaction. It interacts with 3-pyridinecarboxylic acid to replace the hydrogen atom at a specific position. This is a key step in the reaction. After adding, heat up to a suitable temperature to maintain the constant temperature of the reaction system. This temperature needs to be carefully controlled. If it is too high, side reactions will increase, and if it is too low, the reaction rate will be delayed. Generally speaking, 80-100 ° C is the appropriate temperature.
During the reaction process, the reaction progress can be closely monitored by means such as thin-layer chromatography. When the reaction reaches the desired level, cool the reaction solution to room temperature. After cooling, carefully pour an appropriate amount of ice water. At this time, the solution is diluted and some unreacted reagents and products can be separated. Then carefully adjust the pH value of the solution with a suitable alkali solution, such as sodium hydroxide solution, so that the product can be precipitated in a suitable form. The adjustment process needs to be cautious. If the pH value is too high or too low, it will affect the purity and yield of the product. After
, the precipitated solid is filtered out by filtration, and the resulting filter cake is washed several times with an appropriate amount of distilled water to remove impurities. After washing, the filter cake is placed in an oven, and dried at a suitable temperature and time. Finally, a pure 2-chloro-3-pyridinecarboxylic acid product can be obtained. Although this preparation method is complicated, each step complements each other. Under careful operation, a product with higher purity and yield can be obtained.

I look at your question, but I am inquiring about the market price range of 2-chloro-3-pyridinecarboxylic acid. However, the price of this chemical often varies with time and place, supply and demand, quality and suppliers, so it is difficult to determine the exact number.
In the past, in the chemical market, if this 2-chloro-3-pyridinecarboxylic acid is found in small quantities, the retail price may be between a few yuan and a few tens of yuan per gram. If it is purchased in bulk, the supplier may prefer it due to large quantities, and the price per kilogram may be between hundreds and thousands of yuan.
However, the chemical market is changing rapidly. The relationship between supply and demand is very huge. If there are many people seeking, but there are few producers, the price will rise; conversely, if the supply exceeds the demand, the price will drop. And the quality is different, and the price is also different. High purity, the price is often high; less, the price may be slightly lower.
To know the exact price, when you go to the chemical raw material market in person, or consult the chemical supplier, ask the current price in detail, you can get the truth. Or on the chemical trading network platform, you can also get a little idea of the recent transaction price.