2-CHLORO-3-PYRIDINE CARBOXYLIC ACID

2-Chloro-3-pyridinecarboxylic acid has a wide range of uses. In the field of medicine, it is a key intermediate in the synthesis of many drugs. For example, when developing antibacterial and antiviral drugs, it is often used as a starting material to build a drug molecular framework through a series of chemical reactions. By modifying and modifying its structure, it endows the drug with specific physiological activities and pharmacological effects, so as to effectively deal with corresponding diseases.
In the pesticide industry, this compound also plays an important role. It can be used to create new pesticides, such as insecticides, fungicides, etc. Because of its specific chemical structure and properties, it can affect the physiological processes of pests, achieve the purpose of efficient prevention and control of pests and diseases, ensure the healthy growth of crops, and improve crop yield and quality.
In the field of materials science, 2-chloro-3-pyridinecarboxylic acid also has applications. It can participate in the synthesis of some functional materials and give special properties to materials by reacting with other substances, such as improving the stability and conductivity of materials. It is widely used in electronic devices, optical materials and other fields to promote the development and innovation of materials science.
To sum up, 2-chloro-3-pyridinecarboxylic acid plays an important role in many fields such as medicine, pesticides and materials science, and is of great significance to technological progress and industrial development in various fields.

2-Chloro-3-pyridinecarboxylic acid, which is white to pale yellow crystalline powder. Its melting point is quite critical, between 148-152 ° C. This characteristic can be used for identification and purity judgment. The melting point accurately reflects the stability and purity of its molecular structure.
In terms of solubility, 2-chloro-3-pyridinecarboxylic acid is slightly soluble in water, but it exhibits good solubility in organic solvents such as methanol, ethanol, and acetone. This difference in solubility is due to the fact that its molecular structure contains both polar carboxyl groups and relatively non-polar pyridine rings and chlorine atoms. Polar carboxylic groups enable molecules to interact with water molecules to some extent, but the pyridine ring and chlorine atoms reduce the overall polarity, resulting in limited solubility in water, and are more easily dispersed and dissolved in near-polar organic solvents.
Its stability is also an important consideration. Under conventional environmental conditions, 2-chloro-3-pyridine carboxylic acids are relatively stable. However, in the case of strong acids, strong bases, or high temperature and high humidity environments, chemical reactions will also occur. For example, under the action of strong bases, carboxyl groups will react with bases to form corresponding carboxylic salts; at high temperatures, chemical bonds within molecules may be rearranged and broken, resulting in structural and property changes.
In addition, 2-chloro-3-pyridinecarboxylic acids are still mild in chemical properties at room temperature and pressure, and are not easy to spontaneously initiate violent reactions. However, in specific chemical reaction scenarios, because they contain carboxyl groups and chlorine atoms, both of which are active functional groups, they can participate in many reactions, such as carboxyl groups can undergo esterification reactions, chlorine atoms can undergo substitution reactions, etc., which have important application value in the field of organic synthesis.

2-Chloro-3-pyridinecarboxylic acid, this is an organic compound. Looking at its structure, it contains chlorine atoms, pyridine rings and carboxyl groups, which give it unique chemical properties.
First of all, its acidity. Because of its carboxyl group, hydrogen ions can be dissociated in water, making it acidic. In the carboxyl group, the electron cloud density of the hydroxyl oxygen atom decreases due to the influence of the carbonyl group, which enhances the polarity of the hydrogen-oxygen bond, and the hydrogen atom is easy to leave in the form of hydrogen ions, so it can neutralize with the base to form the corresponding salt and water.
Furthermore, the presence of chlorine atoms makes the compound have some properties of halogenated hydrocarbons. Chlorine atoms are highly active and can participate in substitution For example, under appropriate conditions, nucleophiles can attack carbon atoms attached to chlorine atoms, and chlorine atoms are replaced by nucleophiles to form new compounds.
Pyridine rings also have a significant impact on their properties. Pyridine rings are aromatic and have a special electron cloud distribution, which makes the electron cloud density of carbon atoms on the ring uneven. The electronegativity of nitrogen atoms is larger than that of carbon atoms, and the electron cloud density of carbon atoms adjacent to nitrogen atoms on the ring is relatively low, which is more prone to electrophilic substitution reactions. The electron cloud density of carbon atoms far away from nitrogen atoms is relatively high, and under certain conditions, nucleophilic substitution reactions can occur.
In addition, 2-chloro-3-pyridinecarboxylic acid can be used as an important intermediate in organic synthesis because it contains a variety of active groups. With its acidic, halogenated hydrocarbon properties and reactivity of pyridine rings, it can participate in many organic reactions and synthesize various complex organic compounds, which have important applications in medicine, pesticides, materials and other fields.

The method of preparing 2-chloro-3-pyridinecarboxylic acid has been studied by many scholars in the past, but now it is detailed by you.
One method is to use 3-pyridinecarboxylic acid as the starting material. Shilling 3-pyridinecarboxylic acid and appropriate chlorinated reagents, such as thionyl chloride, phosphorus oxychloride, etc., are co-heated under suitable reaction conditions. In this process, the chlorine atom of the chlorinated reagent replaces the hydrogen atom at a specific position on the pyridine ring. After carefully controlling the reaction temperature, time and material ratio, a higher yield can be achieved. Usually the reaction temperature can be controlled between tens of degrees Celsius and more than 100 degrees Celsius, and the reaction time needs to be adjusted according to the specific situation, ranging from about ten hours to ten hours After the reaction is completed, the pure 2-chloro-3-pyridinecarboxylic acid can be obtained through post-treatment steps such as distillation and crystallization.
There are also those who use 2-amino-3-pyridinecarboxylic acid as raw material. First, 2-amino-3-pyridinecarboxylic acid is diazotized, and a diazotization reagent composed of sodium nitrite and inorganic acid is often used to react in a low temperature environment to generate diazonium salts. Subsequently, the diazonium salt is reacted with copper salts such as cuprous chloride, and the diazoyl group is replaced by chlorine atoms to obtain the target product. This process requires strict reaction conditions, and the low temperature conditions need to be precisely controlled to prevent the decomposition of diazonium salts. And the connection between each step also requires fine operation to ensure the smooth progress of the reaction and improve the purity and yield of the product.
Furthermore, 2-hydroxy-3-picolinecarboxylic acid is used as the starting material. Halogenating agents, such as phosphorus pentachloride, phosphorus trichloride, etc., can be used to replace hydroxyl groups with chlorine atoms. During the reaction, suitable solvents, such as dichloromethane and chloroform, need to be selected to promote the reaction. During the reaction process, pay close attention to the reaction process and monitor the degree of reaction by means of thin-layer chromatography. After the reaction is completed, 2-chloro-3-picolinecarboxylic acid can be obtained through purification steps such as extraction, drying, and column chromatography.
All kinds of synthetic methods have their own advantages and disadvantages. Experimenters should choose carefully and operate carefully according to their own conditions and needs to achieve the purpose of preparation.

The price of 2-chloro-3-pyridinecarboxylic acid in the market varies from time to time, and it is related to various reasons, so it is difficult to determine.
Looking back at the past, the price of this chemical was often affected by the amount of raw materials, the difficulty of the production method, and the change of the market demand. If the raw materials are abundant, the price may be stable, or even decline; if the raw materials are scarce, the price will rise. If the production method is refined, the cost will decrease and the price may decrease; however, if the production method is complicated and the cost is high, the price will be difficult to lower.
The movement of the market demand is also a major reason. If there is a large increase in demand for this product in the industry, the supply will exceed the demand, and the price will rise; on the contrary, if there is less supply and more supply, the price will decline.
The price of past transactions may fluctuate between tens of yuan and hundreds of yuan per kilogram. However, today is different from the past. If you want to get an accurate price, you can consult the chemical trading platform and chemical raw material suppliers to get the current real price.