2-CHLORO-3-NITRO-5-FLUOROPYRIDINE

2-Chloro-3-nitro-5-fluoropyridine, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it can be called an important intermediate. Due to its unique chemical structure, it can undergo many chemical reactions to build a complex drug molecular structure. For example, when developing antibacterial, anti-cancer and other drugs, it is often used as the starting material. Through precise organic synthesis methods, specific functional groups are added or changed, and pharmaceutical ingredients with specific pharmacological activities are gradually cast.
In the field of pesticide creation, it also plays a key role. With its chemical properties, efficient and low-toxic pesticide varieties can be derived. Such pesticides have a significant killing or inhibitory effect on pests, and at the same time have a relatively slight impact on the environment, which is in line with the current needs of green agriculture development. For example, for specific crop pests, pesticides developed based on 2-chloro-3-nitro-5-fluoropyridine can precisely target pests, while causing little damage to the crop itself and the surrounding ecological environment.
In addition, in the field of materials science, it has also emerged. Because it can participate in specific polymerization reactions, polymer materials with special properties can be synthesized. Such materials may have good heat resistance, chemical stability, etc., and can be applied to industries such as electronics and aerospace that require strict material properties, providing new material options for the development of related fields.

2-Chloro-3-nitro-5-fluoropyridine is a crucial compound in the field of organic synthesis. Its physical properties are unique and have a profound impact on the reaction path and product characteristics of organic synthesis.
Looking at its properties, under room temperature and pressure, 2-chloro-3-nitro-5-fluoropyridine is mostly light yellow to light brown crystalline powder. This morphological feature is easy to store and transport, and lays the foundation for its participation in various chemical reactions.
When it comes to the melting point, the melting point of this compound is about [X] ° C. As an important physical parameter of a substance, the melting point reflects the strength of intermolecular forces. The higher melting point indicates that the intermolecular force is strong, the structure is relatively stable, and it can maintain its own structure in the synthesis reaction, ensuring that the reaction proceeds in a specific direction.
In terms of boiling point, it is about [X] ° C. The boiling point reflects the volatility of the compound, and the boiling point of 2-chloro-3-nitro-5-fluoropyridine determines the difficulty of gasification under heating conditions, which is of great significance for the separation and purification steps in the reaction process.
Solubility is also a key property. It is slightly soluble in water, but soluble in common organic solvents such as dichloromethane, chloroform, ethanol, etc. This solubility property allows it to fully contact with different reactants in organic synthesis and achieve efficient reactions in suitable solvent systems.
In addition, 2-chloro-3-nitro-5-fluoropyridine has certain stability. However, under specific conditions, such as high temperature, strong acid, and strong base environments, its structure contains chlorine atoms, nitro groups, and fluorine atoms or participates in the reaction, exhibiting active chemical properties. The coexistence of this stability and reactivity allows organic synthesis chemists to use ingenious design of reaction conditions to achieve precise modification and transformation of the compound and synthesize the target product.

Fu 2 - CHLORO - 3 - NITRO - 5 - FLUOROPYRIDINE has various synthesis methods. First, it can be obtained from the starting material containing pyridine by various reactions such as halogenation and nitrification.
First, use a suitable pyridine derivative as a base, and under specific conditions, use a chlorination reagent, such as sulfoxide chloride, to carry out a chlorination reaction, which can introduce chlorine atoms into the pyridine ring. When chlorinating, pay attention to the temperature, time and amount of reagent of the reaction to control the check point and process of the reaction.
Then, introduce nitro groups. A mixed acid system of concentrated nitric acid and concentrated sulfuric acid can be used to carry out nitrification reaction. This step also requires careful temperature control, because the nitrification reaction is violent, if the temperature is not appropriate, it is easy to cause a cluster of side reactions, such as the formation of polynitrification products. And the electron cloud distribution of the pyridine ring has a significant impact on the reaction check point, so it needs to be precisely controlled.
Furthermore, fluorine atoms are introduced. A nucleophilic substitution reaction can be used to replace specific groups on the pyridine ring, such as halogen atoms, with suitable fluorine-containing reagents, such as potassium fluoride, under the action of specific solvents and catalysts. However, the reaction conditions in this step also need to be carefully regulated. The polarity of the solvent, the type and dosage of the catalyst are all related to the success or failure of the reaction and the yield.
Or, you can find another way, starting from different starting materials, through multi-step reactions, ingeniously construct pyridine rings, and introduce chlorine, nitro, fluorine and other groups. This requires a deep understanding of the mechanism and strategy of organic synthesis, and a comprehensive consideration of the feasibility and sequence of each step of the reaction, in order to achieve the purpose of efficient synthesis.
In short, the method of synthesizing 2 - CHLORO - 3 - NITRO - 5 - FLUOROPYRIDINE, whether complex or simple, depends on the exquisite skills of organic synthesis and careful control of the conditions of each step of the reaction.

2-Chloro-3-nitro-5-fluoropyridine is also a chemical substance. During storage and transportation, many matters need to be paid attention to.
First of all, storage, this substance should be stored in a cool, dry and well-ventilated place. Because the cool environment can avoid the change of its properties caused by excessive temperature, the dry state can avoid the chemical reaction caused by moisture, and the good ventilation can disperse the harmful gases that may accumulate. And it needs to be kept away from fire and heat sources, because it has certain chemical activity, in case of open fire, hot topic or dangerous, such as burning or even explosion.
In addition, it should be stored separately from oxidants and edible chemicals. Oxidants have strong oxidizing properties and may come into contact with them or react violently; edible chemicals are related to human dietary safety, and may mix with them or cause pollution, endangering life and health. The storage place should also be equipped with suitable materials to contain leaks, in case of leakage, which can be dealt with in time to reduce their harm.
As for transportation, the transportation vehicle should ensure that the vehicle is in good condition and has corresponding safety facilities. During transportation, it must be protected from exposure to the sun, rain, and high temperature. When it is hot in summer, exposure to the sun and rain may cause damage to the packaging and material leakage. When transporting, you should also follow the prescribed route and do not stop in densely populated areas and downtown areas. Because it may be toxic and corrosive, if it leaks in a crowded place, it will endanger many lives. When loading and unloading, operators must strictly abide by the operating procedures and unload lightly to avoid package damage due to rough operation, causing material leakage and endangering the environment and personal safety.

What you are asking is the market price of 2-chloro-3-nitro-5-fluoropyridine. The price of this chemical is difficult to say in a word, due to the intertwined influence of many factors.
First, the price of raw materials plays a crucial role in their cost. If the price of chlorine, nitro, fluorine and other related raw materials required for its preparation fluctuates, the price of 2-chloro-3-nitro-5-fluoropyridine will also fluctuate. If the supply of raw materials is abundant and the price is flat, the price of the product may stabilize and be low; if the raw materials are scarce, the price will rise, and this product will not be spared.
Second, whether the production process is simple and advanced or not, also affects the price. If the process is complex and requires high-end equipment and technology, the production cost will be high and the price will not be low. However, if the new process comes out, it can simplify the process, reduce energy consumption, and improve the yield, then the price may have room for reduction.
Third, the market supply and demand trend is a key factor. If the market has strong demand for this chemical and the supply is limited, the so-called rare is expensive, and the price will be high; conversely, if the supply exceeds the demand, the merchant will destock or reduce the price.
Fourth, regional differences also lead to price differences. In different places, prices may vary due to differences in transportation costs, tax policies, and the degree of market competition. If the transportation is convenient and the industry is concentrated, the cost may be low, and the price may also be more advantageous.
To know the exact price, it is advisable to consult chemical product suppliers, traders, or refer to real-time quotations on chemical product trading platforms, so that accurate market price information can be obtained.