2-Chloro-3-Methylpyridine-5-Boronic Acid

2-Chloro-3-methylpyridine-5-boronic acid, this substance has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
First, it plays an important role in medicinal chemistry. The construction of many drug molecules requires the participation of such boron-containing compounds. By coupling with other organic fragments, complex and specific active drug structures can be precisely constructed to help develop new therapeutic drugs, such as innovative drugs targeting specific disease targets.
Second, in the field of materials science, it also has outstanding performance. It can be used to prepare functional materials, such as organic optoelectronic materials. With its unique chemical properties, it is introduced into the material structure through appropriate reactions to improve the optical and electrical properties of the material, and enhance the application efficiency of the material in devices such as Light Emitting Diode and solar cells.
Third, in the field of fine chemicals, it is widely used in the synthesis of various fine chemicals. Through ingeniously designed chemical reactions, combined with different reagents, fine chemical products with special functions or structures are prepared, such as special catalysts, additives, etc. These products are of great significance to the chemical production process and product quality improvement. In short, 2-chloro-3-methylpyridine-5-boronic acid has become an indispensable chemical raw material in many important fields due to its active chemical properties and unique structure.

The synthesis of 2-chloro-3-methylpyridine-5-boronic acid is an important topic in the field of organic synthesis. The synthesis paths are diverse, and the following are common methods.
First, halogenated pyridine derivatives are used as starting materials. Usually 2-chloro-3-methyl-5-halogenated pyridine is selected and treated with appropriate organometallic reagents, such as n-butyllithium (n-BuLi). n-butyllithium can undergo lithium-halogen exchange reaction with halogenated pyridine, and lithium atoms are introduced at specific positions in the pyridine ring to form corresponding lithiated pyridine intermediates. Subsequently, this intermediate is reacted with borate esters, such as trimethyl borate (B (OMe)
Second, transition metal catalysis can also be used. Using 2-chloro-3-methylpyridine as a substrate, in the presence of transition metal catalysts such as palladium, such as tetra (triphenylphosphine) palladium (Pd (PPh)), the transition metal catalyst is first coordinated with the substrate and boron reagent, such as boronyl boronate ester (B ³ pin ³). During this reaction process, the transition metal catalyst is first coordinated with the substrate and boron reagent, and through the steps of oxidative addition, transmetallization and reduction elimination, boric acid groups are introduced into the 5-position of the pyridine ring to obtain the target product 2-chloro-3-methylpyridine-5-boronic acid. This method has relatively mild conditions and high selectivity.
Thirdly, pyridine boronic acid derivatives are used as raw materials and synthesized through selective substitution reaction. First, appropriate pyridine boronic acid derivatives are prepared, using the substituent-directed effect on the pyridine ring, combined with specific halogenated reagents, under suitable reaction conditions, selectively introduce chlorine atoms at the 2-position of the pyridine ring and methyl groups at the 3-position to synthesize 2-chloro-3-methylpyridine-5-boronic acid.
Different synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, the purity and yield of the target product, etc., in order to choose the most suitable synthesis path.

2-Chloro-3-methylpyridine-5-boronic acid, this substance is white to off-white solid, with fine texture and pure color. Its melting point is quite important, about a specific range (although the exact value needs to be determined by precise experiments). This melting point characteristic is of great significance in the identification and purification process.
In terms of solubility, it has a certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide, but its solubility in water is relatively limited. This difference in solubility allows for the chemical synthesis operation to choose a suitable solvent according to the needs to achieve the best reaction effect.
In terms of stability, under normal environmental conditions, if properly stored, it can maintain a relatively stable state. However, it must be avoided from contact with strong oxidizing agents, strong bases and other substances. Due to the characteristics of boric acid groups and pyridine rings in the chemical structure, it is easy to cause chemical reactions when encountering such substances, resulting in structural changes, which affect their quality and performance.
Furthermore, the chemical activity of 2-chloro-3-methylpyridine-5-boronic acid is mainly due to the chlorine atoms and boric acid groups it contains. Chlorine atoms can participate in nucleophilic substitution reactions, while boric acid groups play a key role in many organic synthesis reactions such as Suzuki coupling reactions, exhibiting unique reactivity and providing an important basis for the construction of more complex compounds in the field of organic synthesis.

2-Chloro-3-methylpyridine-5-boronic acid requires more attention when storing and transporting. This compound has specific chemical properties, so the relevant operation must be done with caution.
First, store in a dry and cool place. Because it is quite sensitive to humidity and temperature, it is easy to hydrolyze in a humid environment, and high temperature may cause decomposition. Therefore, it should be stored in a constant temperature and dry storage. The temperature should be maintained at 2-8 ° C. This temperature range can maintain its chemical stability and delay the rate of deterioration.
Furthermore, the storage place must be kept away from fire sources and oxidants. 2-Chloro-3-methylpyridine-5-boronic acid may cause combustion and explosion when exposed to open flames, hot topics or contact with oxidants. It should be separated from oxidants and flammable substances to avoid potential dangers.
As for transportation, there are also many points. Packaging must be tight to prevent leakage. Commonly used packaging materials must be able to withstand certain pressure and vibration, and have good sealing. During transportation, strict temperature control is required to prevent excessive temperature fluctuations. Vehicles should be selected to drive smoothly to avoid bumps and vibrations and prevent material leakage caused by damaged packaging.
At the same time, transport personnel should be familiar with the characteristics of this chemical and emergency treatment methods. If a leak occurs, the scene should be quickly isolated and surrounding people evacuated. Emergency responders should wear professional protective equipment and follow the correct handling procedures to clean up the leak to prevent harm to the environment and people.

I think what you are asking is about the market price of 2-chloro-3-methylpyridine-5-boronic acid. However, the price of this chemical often changes for many reasons, and it is difficult to answer exactly.
First, the situation of supply and demand has a great impact. If the market demand for this product is strong and the supply is limited, its price will rise; conversely, if the supply exceeds demand, the price will easily drop. Second, the price of raw materials is also the key. The preparation of this chemical requires specific raw materials, and the price of raw materials fluctuates, which will inevitably cause the price of finished products to fluctuate. Third, the difficulty of preparation also affects its price. If the preparation process is complicated, the requirements for technology and equipment are very high, and the cost increases, the price will also increase accordingly.
Furthermore, the prices set by different suppliers are also different. Well-known and reputable suppliers may have relatively high prices due to high product quality and comprehensive service; while new entrants to the market or smaller suppliers may compete for share and may attract customers at low prices.
And the market is located in different regions, and the prices are also different. In places with convenient transportation and developed economy, the price may be more reasonable due to low logistics costs and fierce market competition; while in remote places, the price may be higher due to increased costs such as transportation.
Therefore, in order to know the exact market price of 2-chloro-3-methylpyridine-5-boronic acid, it is necessary to carefully investigate the market supply and demand, raw material conditions, and consult different suppliers, and comprehensively consider, in order to obtain more accurate price information.