2-Chloro-3-fluoropyridine-5-boronic acid

2-Chloro-3-fluoropyridine-5-boronic acid is a reagent commonly used in organic synthesis. Its physical properties are quite characteristic, let me explain in detail for you.
This substance is mostly solid under normal conditions. Looking at its color, or it is a white to off-white powder, with a fine appearance. This morphology is also common in many organic compounds. Its melting point is a key characteristic for identification, and it is usually in a specific temperature range. This temperature value can help chemists to accurately identify and purify the substance in experiments. If heated to the melting point, the compound gradually melts from a solid state to a liquid state. This phase transition process follows the physical laws of matter.
Furthermore, its solubility cannot be ignored. In the environment of organic solvents, 2-chloro-3-fluoropyridine-5-boronic acid exhibits different degrees of solubility. Common organic solvents, such as dichloromethane and tetrahydrofuran, have a certain solubility to this substance. In dichloromethane, a uniform solution can be formed, which is conducive to the progress of the reaction in organic synthesis. Because the reactants are in the solution state, the collision between molecules is more frequent, and the reaction rate is improved. However, in water, its solubility is poor. Because the molecular structure of the compound is dominated by hydrophobic groups, the interaction between it and water molecules is weak.
In addition, the stability of 2-chloro-3-fluoropyridine-5-boronic acid is also an important physical property. Under normal storage conditions, such as dry and cool places, this substance can be stored for a certain period of time without significant chemical changes. However, in case of extreme conditions such as high temperature, high humidity or strong oxidizing agents and strong reducing agents, its chemical structure may be damaged, which will affect its application effect in organic synthesis reactions.

To prepare 2-chloro-3-fluoropyridine-5-boronic acid, there are two common methods. First, 2-chloro-3-fluoropyridine is used as the starting material, and the lithium reaction is first carried out. In a low temperature environment, strong base reagents such as n-butyl lithium are used to lithify the pyridine ring at a specific position, and then react with borate ester reagents (such as trimethyl borate). This process requires strict temperature control. Due to the high lithiation reactivity, improper temperature is prone to side reactions. After the reaction is completed, the target product 2-chloro-3-fluoropyridine-5-boronic acid can be obtained by hydrolysis step and treatment with dilute acid (such as dilute hydrochloric acid).
Second, the metal-catalyzed coupling method of halopyridine is used. Using 2-chloro-3-fluoro-5-halopyridine (such as 5-bromide) as the starting material, in the presence of transition metal catalysts such as palladium (such as tetra (triphenylphosphine) palladium) and ligands, the coupling reaction occurs with boron reagents (such as diphenacol borate). In the reaction system, suitable bases (such as potassium carbonate, etc.) need to be added to promote the reaction. This reaction condition is relatively mild, but it requires high selection of catalysts and ligands, and different combinations affect the reaction efficiency and selectivity. After reaction post-treatment, such as extraction, column chromatography and other purification methods, pure 2-chloro-3-fluoropyridine-5-boronic acid can be obtained.

2-Chloro-3-fluoropyridine-5-boronic acid is widely used in the field of pharmaceutical synthesis. Cover because of its unique chemical structure, can introduce specific functional groups for drug molecules, help to build a variety of active structures, and then create new and efficient drugs. For example, in the development of antibacterial drugs, using this substance to participate in the reaction may optimize the affinity of drugs to bacterial targets and improve antibacterial efficacy.
In the field of materials science, there is also no shortage of its role. In the preparation of organic optoelectronic materials, 2-chloro-3-fluoropyridine-5-boronic acid can be used as a key building block. Through specific chemical reactions, it can be integrated into the polymer skeleton, which may endow the material with unique photoelectric properties, such as changing the fluorescence emission wavelength of the material and improving the carrier mobility, etc., which can help the development of organic Light Emitting Diode (OLED), organic solar cells and other devices.
Furthermore, in the field of catalytic chemistry, it also has applications. In some transition metal-catalyzed coupling reactions, it can act as a ligand or substrate to participate in the formation of complex organic molecular structures. With its boron atom properties, it can effectively regulate the reaction activity and selectivity, achieve efficient synthesis under mild conditions, promote the progress of organic synthetic chemistry, and open up new paths for the preparation of high value-added fine chemicals.

The market price of 2-chloro-3-fluoropyridine-5-boronic acid often varies due to many factors, and it is difficult to determine a certain number. As described in "Tiangong Kaiwu", the price of all things in the world varies according to time, place, quality, and demand. The same is true for this compound.
From the origin, if the origin is close to the raw material production area and the transportation is convenient, the production cost will be reduced, and the price may be slightly lower; if the origin is remote and the transportation cost is high, the price will rise. On the other hand, those with high purity are difficult to prepare, time-consuming and expensive, and expensive for high-end scientific research and pharmaceutical purposes; those with low purity are more suitable for general industrial purposes, and the price is low.
Market supply and demand are also key. If there is a large increase in demand in fields such as pharmaceutical research and development, the supply will be difficult for a while, and the price will rise; if there is less demand and more supply, the merchant will sell or reduce the price.
To know the exact price, you should consult the supplier of chemical raw materials. Because the market is changing rapidly, they can quote the real-time price according to the current situation. Or you can refer to the past transaction records of the chemical product trading platform. Although it is not the latest, it can also show the approximate price fluctuation, and help merchants and users to estimate the price of this product.

2-Chloro-3-fluoropyridine-5-boronic acid is one of the chemical substances. Its storage conditions are crucial and related to the stability and quality of the substance.
This compound should be stored in a cool and dry place. A cool environment can slow down the rate of its chemical change. If the cover temperature is too high, it often causes chemical reactions to accelerate, or causes material decomposition and deterioration. If the place is hot in the summer, the sun is exposed, and the temperature rises, the boric acid may cause adverse changes.
A dry environment is also indispensable. Water vapor in the air, or interacts with the boric acid, triggers reactions such as hydrolysis, which damage its purity and structure. Therefore, it should be avoided in a humid place, such as near water corners, cellars and wet places.
Furthermore, it needs to be placed in a sealed container. To prevent it from contacting oxygen, carbon dioxide and other gases in the air, prevent oxidation or other chemical reactions; Second, to prevent external impurities from mixing in to keep it pure.
During access and storage, it should also be kept away from fire and heat sources. Fire sources and heat sources are prone to sudden temperature rises, putting the substance in a dangerous environment, or there is a risk of combustion or explosion.
The storage place should also be well ventilated. Good ventilation can dissipate harmful gases that may be generated, reduce safety risks, and ensure the safety of the storage environment.
In terms of records, the start date of storage, changes in conditions and other information should be recorded in detail. In this way, it is convenient to trace and monitor the storage status of the substance. Once there is an abnormality, the cause can be found according to the records and disposed of in time.
After all, the storage of 2-chloro-3-fluoropyridine-5-boronic acid needs to be cool, dry, sealed, protected from fire, heat, ventilated, and recorded in detail, so as to properly store it and maintain its quality and efficiency.