2 Chloro 3 Fluoropyridine 4 Carboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

2-Chloro-3-fluoropyridine-4-carboxylic acid

    Specifications

    HS Code

    401479

    Chemical Formula C6H3ClFNO2
    Molecular Weight 175.545 g/mol
    Appearance Solid (predicted)
    Boiling Point 312.7°C at 760 mmHg (predicted)
    Melting Point 165 - 169 °C
    Density 1.539 g/cm³ (predicted)
    Flash Point 142.9°C (predicted)
    Solubility In Water Poor (predicted)
    Pka 2.43 (predicted)
    Vapor Pressure 0.000132 mmHg at 25°C (predicted)

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    General Information
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    Frequently Asked Questions

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    What is the main use of 2-chloro-3-fluoropyridine-4-carboxylic acid?
    2-% -3-enyl to its-4-butyric acid is an important chemical compound, which has important uses in many fields.
    First, in the chemical field, this chemical compound is often used in the synthesis of chemical compounds. Due to its special chemical properties, it can be modified and synthesized with specific effects. For example, some of the products synthesized from this group can be used for human physiology, such as affecting the activity of specific enzymes and treating diseases. Like some cardiovascular disease compounds, in their synthesis pathways, 2-% 3-enes are used as important starting materials or intermediate materials for their 4-butyric acid derivatives. This polymer material can be used in the fields of photonic devices, biological materials, etc. For example, in biological materials, polymers based on this compound are specially synthesized. Due to their good biocompatibility and degradability, they can be used in the production of raw materials to control the release rate of raw materials and improve the efficiency of raw materials.
    Third, in the synthesis of raw materials, 2-%-3-ethylenes are used as important synthesizers to their 4-butyric acid, which can be used for multiple reactions. For example, carbon-carbon formation reactions, functionalization reactions, etc., by means of ingenious reactions, with their starting materials, various compounds with different functionalities and skeletons can be efficiently synthesized, providing an important foundation for the development of synthetic materials.
    What are the synthesis methods of 2-chloro-3-fluoropyridine-4-carboxylic acid?
    To prepare 2-cyanogen-3-chloropyridine-4-carboxylic acid, there are various methods.
    First, the corresponding pyridine derivative can be started. First, a suitable pyridine substrate is taken, and the hydrogen at a specific position is replaced by a chlorine atom through a halogenation reaction. In this step, suitable halogenation reagents and conditions are selected to ensure that the chlorine atom falls precisely at the 3-position. Then, a cyanide group is introduced, which is often reacted with a cyanide reagent and an intermediate, and the cyanide group is entered at the 2-position. Then, the specific group is converted into a carboxyl group, or hydrolyzed to obtain the target 2-cyanogen-3-chloropyridine-4-carboxylic acid. In this path, the control of the reaction conditions at each step is very important, such as the temperature during halogenation, the proportion of reagents, the reaction environment during cyanidation, and the conditions of hydrolysis, all of which are related to the yield and purity of the product.
    Second, other nitrogen-containing heterocyclic compounds are also used as starting materials. After a series of rearrangements and substitution reactions, pyridine rings are gradually built, and cyano groups, chlorine atoms and carboxyl groups are introduced. This approach requires familiarity with the mechanism of heterocyclic reactions, ingenious design of reaction steps, close connection of each step of the reaction, and careful consideration and avoidance of possible side reactions in the reaction.
    Furthermore, metal-catalyzed reactions may be used. Metal catalysts are used to activate the substrate to promote the selective reaction of cyanyl and chlorine atoms with specific positions on the pyridine ring. The choice of metal catalysts is crucial, and different metals and their ligands have different effects on the reaction activity and selectivity. At the same time, the pH of the reaction system, solvents and other factors also need to be carefully controlled to make the reaction proceed smoothly and efficiently prepare 2-cyano-3-chloropyridine-4-carboxylic acid.
    All these production methods have advantages and disadvantages. In actual preparation, the optimal method is selected according to factors such as raw material availability, cost, yield and purity requirements.
    What are the physical properties of 2-chloro-3-fluoropyridine-4-carboxylic acids?
    2-% heptyl-3-enyl-4-alkynylic acid is an organic compound with unique physical properties, as follows:
    - ** Appearance and Properties **: Under normal temperature and pressure, 2-heptyl-3-enyl-4-alkynylic acid mostly appears as a colorless to light yellow oily liquid. This morphology is closely related to its molecular structure. The carbon-carbon double bonds and triple bonds contained in the molecule give the molecule a certain degree of unsaturation, which in turn affects the intermolecular forces, causing it to exist in the world as a liquid at room temperature. < Br > - ** Melting point and boiling point **: Due to the existence of a conjugated system in the molecule, the intermolecular force is enhanced, so the melting point of the substance is low, about - 20 ° C; the boiling point is relatively high, between 230 - 240 ° C. This melting point and boiling point characteristic is of crucial significance when separating, purifying and storing it.
    - ** Solubility **: 2-heptyl-3-enyl-4-alkynic acid is slightly soluble in water, but highly soluble in most organic solvents, such as ethanol, ether, chloroform, etc. This difference in solubility is due to the fact that there are both hydrophilic carboxyl groups and hydrophobic long chains of hydrocarbons and unsaturated bonds in their molecular structures. The hydrophilic carboxyl group gives the molecule a certain affinity for water, but the hydrophobic part dominates, resulting in its overall limited solubility in water and more soluble in organic solvents.
    - ** Density **: Its density is slightly higher than that of water, about 1.05 g/cm ³. This density characteristic requires special attention when dealing with the operation of the mixture system of this substance and water, because it will sink in water.
    - ** Odor **: The substance emits a weak and special pungent odor. The production of this odor is related to the carboxyl groups and unsaturated bonds in the molecule, which are volatile and stimulate the olfactory nerve, thus making people perceive special odors.
    What is the market prospect of 2-chloro-3-fluoropyridine-4-carboxylic acid?
    The market prospect of 2-% nitrile-3-ene to its-4-carboxylate is quite promising today. Such compounds are useful in many fields, so their market prospects are also becoming broader.
    First in the field of medicine. Today's medical research is advanced, and such 2-% nitrile-3-ene to its-4-carboxylate compounds are often the key raw materials for the creation of new drugs. Because of its unique structure and specific biological activity, it can be used in the treatment and prevention of diseases. Doctors are constantly developing drugs for specific diseases, such as anti-tumor and antiviral drugs. And with the increase of population, the spectrum of diseases has also changed, and the need for high-efficiency drugs is increasing. The demand for such compounds in the pharmaceutical market will also rise, and the future will be bright.
    Times and materials fields. 2-% nitrile-3-ene to its-4-carboxylate can be used as an important component in the preparation of special materials due to its unique chemical properties. In the synthesis of polymer materials, the addition of this substance can improve the properties of materials, such as enhancing their stability, toughness, and heat resistance. Today's rapid technology has no choice but to seek advanced materials. High-end fields such as electronics and aerospace require such materials with excellent properties. Therefore, in the materials market, such compounds will also be widely used, and the prospects are quite promising.
    Furthermore, in the field of agriculture. Such compounds may have insecticidal and antibacterial properties, and can be used as raw materials for pesticides. Today's agriculture pays attention to green and environmental protection, and there is a growing demand for high-efficiency and low-toxicity pesticides. If 2-% nitrile-3-ene can meet these requirements to its 4-carboxylate, it will be able to occupy a place in the pesticide market, and contribute to the growth and harvest of crops, and its market prospects are promising.
    However, although the market prospect is beautiful, there are also challenges. Optimization of the synthesis process is one of them. To expand its production scale and reduce its cost, the synthesis process must be more efficient and environmentally friendly. Furthermore, the market competition is also fierce. Similar or alternative products are emerging in an endless stream. To stand out in the market, it is necessary to continuously improve product quality and strengthen R & D innovation in order to stabilize its market position and enjoy a bright future.
    What are the precautions for storing and transporting 2-chloro-3-fluoropyridine-4-carboxylic acids?
    2-% -3-oxygen to its-4-boronic acid in storage and storage, there is a matter of general concern.

    those are flammable and highly reactive. For storage, it needs to be placed in a well-connected place to prevent ignition, oxidation and oxidation. The container must be solid and dense to prevent leakage. Because the density of the container is smaller than that of the air, if the leakage is rapidly rising and accumulating, it is easy to cause explosion in case of open fire or high temperature, so it is appropriate to install reliable flammable alarm devices to detect leakage.
    Oxygen is not flammable, but oxidized. For storage, flammable and combustible materials should also be stored, and they should not be mixed together. The container also needs to be dense to prevent oxygen from escaping. In the container, oxygen bottles and other containers should be properly fixed to avoid collision and shock, which may cause leakage. And it is necessary to deal with the fire and emergency treatment of the phase.
    For boric acid, the compound should be fixed. The storage should be kept in dry and dry conditions to prevent moisture. Due to moisture, its properties may be changed, and it should be used in the shadow. In addition, it is necessary to ensure that the package is in good condition to prevent the boric acid from being scattered due to breakage. If the boric acid accidentally touches the skin or eyes, it should be washed with plenty of water immediately, and it is necessary to seek treatment.
    In this case, 2-3, 3-oxygen and 4-boric acid should be stored in water, each of which has different precautions due to its characteristics, and all of them should be followed to ensure safety.