2-Chloro-3-fluoro-5-(trifluoromethyl)-pyridine

2-Chloro-3-fluoro-5- (trifluoromethyl) pyridine is a crucial compound in the field of organic synthesis. It has a wide range of uses and has significant applications in many fields.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of new drugs. Due to the structure of the pyridine ring and the unique properties of the halogen atom and trifluoromethyl, it is endowed with special biological activity and pharmacokinetic properties. Through ingenious chemical reactions, it can be constructed into drug molecules with specific pharmacological effects. The creation of drugs such as antibacterial, anti-inflammatory, and anti-tumor may involve its participation.
In the field of pesticide chemistry, 2-chloro-3-fluoro-5- (trifluoromethyl) pyridine also plays an important role. It can be used as an important starting material for the synthesis of high-efficiency, low-toxicity and environmentally friendly pesticides. With its structural characteristics, the synthesized pesticides may have excellent insecticidal, bactericidal, weeding and other properties, helping agricultural production to improve yield and quality, while reducing the adverse impact on the environment.
In addition, in the field of materials science, this compound may be used to prepare organic materials with special properties. For example, through its participation in polymerization reactions, or polymer materials with special optical and electrical properties can be prepared, showing potential application value in electronic devices, optical instruments, etc.
In summary, 2-chloro-3-fluoro-5- (trifluoromethyl) pyridine has an indispensable position in many fields such as medicine, pesticides, and materials due to its unique chemical structure, and has made great contributions to promoting scientific and technological progress and industrial development in related fields.

The synthesis method of 2-chloro-3-fluoro-5- (trifluoromethyl) pyridine has been known for a long time. There are many methods, and each has its own advantages. I will choose the main one and describe it for you.
First, pyridine is used as the initial raw material and prepared by multi-step reaction. The chlorine atom is introduced at a specific position on the pyridine ring first. This step requires the selection of an appropriate chlorination reagent, such as thionyl chloride. And the reaction conditions also need to be precisely controlled, such as temperature, time, and the proportion of reactants. A slight difference in the pool will affect the yield and purity. After the chlorine atom is successfully introduced, the fluorine atom is introduced. The method of introducing fluorine atoms is often used for fluorination reagents, such as potassium fluoride. However, in this process, other groups on the pyridine ring may be affected, so it is necessary to operate with caution, or supplemented by the method of protecting the group, so that the fluorine atoms fall exactly at the desired position. Finally, trifluoromethyl is introduced. In this step, or with a reagent containing trifluoromethyl, through a specific reaction mechanism, trifluoromethyl is connected to the pyridine ring, and the target product 2-chloro-3-fluoro-5- (trifluoromethyl) pyridine is obtained.
Second, other nitrogen-containing heterocyclic compounds are also used as starters. After ingeniously designed reaction routes, the structure of the pyridine ring is gradually constructed, and chlorine, fluorine and trifluoromethyl are introduced at the same time. This approach requires in-depth understanding of the reaction characteristics of heterocyclic compounds, and the use of their activity check points to achieve the synthesis of target molecules through a series of reactions such as cyclization and substitution. And each step of the reaction needs to be linked, and the separation and purification of the intermediate product is also very important, which is related to the quality and yield of the final product.
Third, organometallic catalytic synthesis has also attracted much attention. With the unique activity and selectivity of organometallic catalysts, the reaction can be carried out under relatively mild conditions. For example, some palladium, nickel and other metal complex catalysts can effectively promote the coupling reaction between halogenated pyridine and fluorine-containing and trifluoromethyl-containing reagents. This method not only improves the reaction efficiency, but also has better control over the selectivity of the reaction check point, can reduce the occurrence of side reactions, improve the purity of the product, and provide a potential way for the synthesis of 2-chloro-3-fluoro-5- (trifluoromethyl) pyridine.
All these synthetic methods have advantages and disadvantages. In practical applications, it is necessary to consider the specific needs, such as product purity, cost, feasibility of reaction conditions and other factors, and choose the best one.

2-Chloro-3-fluoro-5- (trifluoromethyl) pyridine is an organic compound with unique physical properties. At room temperature, it is a colorless to light yellow liquid with a special odor. The odor is irritating and significant, and it is easy to be perceived.
Looking at its boiling point, it is about 130-140 ° C. The boiling point is established, and it can be known that it starts to boil at a specific temperature. At this temperature, the substance changes from liquid to gaseous state. The melting point is about -30 ° C. The value of the melting point shows that it is solid at this temperature, and the temperature rises above the melting point, and then melts into a liquid state.
When it comes to solubility, this compound is slightly soluble in water. Edge water is a polar solvent, while 2-chloro-3-fluoro-5- (trifluoromethyl) pyridine has limited polarity. According to the principle of similar miscibility, its solubility in water is low. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. The molecular structure of organic solvents such as ethanol has certain similarities with this compound, so it can be miscible.
As for the density, it is about 1.4-1.5 g/cm ³, which is denser than water. If mixed with water, it will sink to the bottom of the water. The vapor pressure of this compound is low, which means that it evaporates relatively slowly at room temperature and pressure.
In addition, the stability of the compound is also an important property. Under normal conditions, it is relatively stable. However, in case of specific chemicals such as strong oxidizing agents and strong bases, or extreme conditions such as high temperature and high pressure, it is easy to chemically react and cause changes in structure and properties.

2-Chloro-3-fluoro-5- (trifluoromethyl) pyridine, this is an organic compound. Its chemical properties are unique, which is actually the key to organic synthesis.
When it comes to reactivity, its reactivity is unique because of the presence of chlorine, fluorine and trifluoromethyl substituents on the pyridine ring. Chlorine atoms have a certain nucleophilic substitution activity, and under appropriate nucleophilic reagents and reaction conditions, nucleophilic substitution reactions can occur. Among them, the nucleophilic properties of nucleophilic reagents, reaction temperatures, solvents and other factors have a great influence on the reaction process. Fluorine atoms are extremely electronegative, which can change the electron cloud density distribution of pyridine rings, thereby affecting molecular reactivity and selectivity. Trifluoromethyl is a strong electron-withdrawing group, which not only enhances the electrophilicity of molecules, but also affects the physical properties of molecules.
In terms of acidity and alkalinity, the pyridine cyclic nitrogen atom has a solitary pair of electrons, accepts protons, and is weakly basic. However, due to the electron-withdrawing effect of the substituent group, its basicity may change compared with that of pyridine. This alkaline property may play a key role in acid-base catalytic reactions.
At the stability level, the existence of fluorine atoms and trifluoromethyl enhances molecular stability. The carbon-fluorine bond energy of the fluorine atom is quite high, and the steric resistance and electronic effect of the trifluoromethyl group make the molecule more stable, which can maintain the structural integrity under specific conditions and is not easy
In terms of solubility, the compound has both polar and non-polar moieties. The pyridine ring and the polar substituent give a certain polarity, while the trifluoromethyl group has non-polar characteristics. Its solubility in organic solvents may vary depending on the polarity of the solvent. In polar organic solvents such as dimethyl sulfoxide, N, N-dimethylformamide, its solubility is better or worse; in non-polar solvents such as n-hexane, its solubility is inferior.
This compound has unique chemical properties and may have broad application prospects in the fields of organic synthesis, medicinal chemistry, etc. It can be used as a key intermediate for the synthesis of compounds with specific biological activities or functions.

I look at this 2-chloro-3-fluoro-5- (trifluoromethyl) -pyridine, it is difficult to assert the market price. The market price is constantly changing and is influenced by many factors.
First, the price of raw materials has a great impact. If the various raw materials required for the synthesis of pyridine are abundant and affordable, the price of the product may also be lower; on the contrary, the raw materials are scarce and the price is high, and the price of the product is high.
Second, the simplicity and cost of the preparation process are also key. If the process is advanced, it can produce efficiently, the energy consumption and loss are low, and the price may be competitive; if the process is complicated and the cost is high, the price will also rise.
Third, the market supply and demand situation cannot be ignored. If the demand for pyridine is strong and the supply is insufficient, the merchant will raise the price in pursuit of profit; if the supply exceeds the demand, the merchant may reduce the price in order to sell.
Fourth, the market competition situation is also related to the price. There are many peers and the competition is fierce. In order to compete for market share, there may be price reductions; if it is exclusive, it may have a pricing advantage.
As for the specific price, I have checked "Tiangong Kaiwu" and found no price of this chemical. In today's market, the price of this pyridine varies from time to time, place to place, and quality to quality, or 100 yuan per gram, or higher, or slightly lower. It is difficult to generalize. It is necessary to check the chemical product trading platform in real time and consult industry experts to obtain a more accurate price.