2-Chloro-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-Chloro-3-fluoro-5- (4,4,5,5-tetramethyl-1,3,2-dioxyboropentyl-2-yl) pyridine is a crucial organoboron compound in the field of organic synthesis. Its main uses are wide, in the field of pharmaceutical chemistry, and it is often used as a key intermediate to facilitate the construction of new drug molecules. Due to the unique electronic properties and reactivity of the Gain boron atom, it can be combined with other organic halides through many reactions, such as the Suzuki-Miyaura coupling reaction, etc., to precisely construct complex drug molecular structures, paving the way for the creation of new drugs with specific biological activities and pharmacological functions.
In the field of materials science, this compound has also emerged. By participating in specific organic synthesis reactions, organic materials with unique photoelectric properties can be prepared. Such materials may show excellent application potential in organic Light Emitting Diodes (OLEDs), organic solar cells and other optoelectronic devices, or can improve the performance and efficiency of devices, and contribute to the development of materials science.
Furthermore, in chemical research, as an important synthetic block, it helps scientists to explore novel chemical reaction paths and mechanisms. With the particularity of its structure, it can inspire researchers to carry out innovative research work, promote the development and improvement of the basic theory of organic chemistry, and inject vitality into the long-term progress of organic synthetic chemistry.

To prepare 2-chloro-3-fluoro-5- (4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl) pyridine, the common synthesis methods are as follows.
One is the esterification of boric acid catalyzed by palladium. First, take the substrate containing halogenated pyridine, such as 2-chloro-3-fluoro-5-halopyridine, and react with diphenacol borate in a suitable solvent in the presence of palladium catalyst, ligand and base. Palladium catalysts are commonly used such as tetra (triphenylphosphine) palladium (0), ligands can be selected such as tri-tert-butyl phosphine, and bases can be selected from potassium carbonate. This reaction condition is mild, and the selectivity to halopyridine is good, which can effectively introduce boronyl groups. The reaction mechanism is that the palladium catalyst first undergoes oxidative addition with halopyridine, then undergoes metal transfer with diphenylpyridyl borate, and finally eliminates the target product by reduction.
The second can be reacted with the corresponding halogen by pyridyl boric acid. First prepare 2-chloro-3-fluoro-5-boronic acid pyridine, and then react with 4, 4, 5, 5-tetramethyl-1, 3, 2-dioxy-boron heterocyclopentane-2-halide under the catalysis of base. Sodium hydroxide and the like can be selected as the base, and dichloromethane as the solvent. In this process, boric acid and halogen are nucleophilically substituted to form the target boron ester compound.
Furthermore, metal-organic reagents can be used. React with 4, 4, 5, 5-tetramethyl-1, 3, 2-dioxy-boron heterocyclopentane-2-halide with lithium or magnesium-containing pyridine metal reagents. First prepare 2-chloro-3-fluoro-5-lithium pyridine or 2-chloro-3-fluoro-5-magnesium pyridine, and then react with boron ester halide in a low temperature and anhydrous and oxygen-free environment. The metal reagent attacks the substrate, and then forms a carbon-boron bond to obtain the product.
The above methods have their own advantages and disadvantages. The actual synthesis needs to be carefully selected according to factors such as raw material availability, cost, yield and purity requirements.

2-Chloro-3-fluoro-5- (4,4,5,5-tetramethyl-1,3,2-dioxyboronheterocyclopentane-2-yl) pyridine is an organic compound. Looking at its physical properties, this substance is mostly solid under normal conditions, and the molecules are arranged in an orderly manner due to the intermolecular force, forming a crystalline structure.
When it comes to the melting point, although there is no exact literature to report it directly, it can be speculated according to the atoms and functional groups in the structure. In its structure, chlorine, fluorine atoms and pyridine rings give molecular polarity, and the boron heterocyclopentane part also participates in the intermolecular action, resulting in an increase in the intermolecular force, so it is speculated that the melting point is relatively high. < Br >
In addition to solubility, because the molecule contains polar groups such as chlorine and fluorine atoms, it may have a certain solubility in polar solvents such as methanol and ethanol. Polar solvents can form hydrogen bonds or dipole-dipole interactions with the polar parts of the compound to help it dissolve. However, due to the presence of non-polar parts such as tetramethyl in the molecule, the solubility in non-polar solvents such as n-hexane should be poor.
As for the density, although there is no accurate data, its density may be greater than that of water based on the type and structure of its atoms. Due to the presence of heavy atoms such as chlorine and boron in the molecule, the molecular mass is increased, and the structure is relatively compact, and the unit volume mass is increased.
The physical properties of this compound are of great significance in the field of organic synthesis. Its solid-state characteristics facilitate storage and transportation; specific solubility helps to select the appropriate solvent in the reaction to achieve the best reaction effect; higher melting points need to be taken into account when controlling reaction conditions to ensure that the temperature of the reaction system meets the requirements of its participation in the reaction.

2-Chloro-3-fluoro-5- (4,4,5,5-tetramethyl-1,3,2-dioxyboron-heterocyclopentane-2-yl) pyridine, which is a commonly used organic boron compound in the field of organic synthesis. Its chemical properties are unique, and it contains the dioxyboron-heterocyclopentane structure attached to the boron atom. Due to the electron-deficient properties of the boron atom, the compound has a certain electrophilicity and can react with nucleophiles under suitable reaction conditions.
From the perspective of substituents, the existence of chlorine and fluorine atoms greatly affects the electron cloud distribution and spatial structure of the compound. Chlorine and fluorine atoms have strong electronegativity and can absorb electrons, which reduces the electron cloud density of the pyridine ring, changes the electrophilic substitution reaction activity on the pyridine ring, and the steric resistance of the two will also play a role in the selectivity of the reaction.
The compound has good thermal stability. In the temperature range of common organic reactions, the structure can usually maintain stability and is not easy to decompose due to heat. When encountering strong oxidants, strong acids or strong bases, its structure may be affected. In case of strong bases, the structure of dioxyboron heterocyclopentane may undergo reactions such as ring opening; in case of strong oxidants, boron atoms may be oxidized, resulting in changes in the structure and properties of the compound.
In addition, the compound has good solubility in organic solvents, such as common organic solvents such as tetrahydrofuran, dichloromethane, N, N-dimethylformamide, which can be well dissolved, which facilitates its participation in various solution-phase organic reactions. In organic synthesis, it is often used to undergo Suzuki-Miyaura coupling reactions with halogenated aromatics to form carbon-carbon bonds to prepare organic compounds containing pyridine skeletons with diverse structures.

There is a question today, what is the market price of 2-chloro-3-fluoro-5- (4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl) pyridine. This is a specific compound in organic chemistry, and its price often varies for many reasons.
First, the difference in purity significantly affects the price. If the purity is very high, it reaches experimental or medicinal grade, and it needs to be purified by subtle and complicated methods, which is very expensive, such as raw materials, equipment, manpower, etc., and the price is high. On the contrary, those with slightly lower purity are easier to prepare, and the cost is reduced and the price is also lower. < Br >
Second, the supply and demand situation determines the price. If the demand for this compound in the fields of pharmaceuticals, materials science and other fields increases greatly, but the supply is limited, the merchant will raise the price to obtain more profits. However, if the supply exceeds the demand, the price will decrease for promotional sales.
Third, the difficulty of preparation is related to cost and price. If there are many synthesis steps, expensive raw materials or harsh conditions are required, the cost will rise, and the price will be high. If the preparation method is simple, the cost is controllable, and the price is relatively low.
In the market, the price of this compound may vary depending on the merchant, region, and period. To know the exact price, consult the chemical reagent supplier in detail or explore the relevant chemical product trading platform to obtain an accurate estimate.