2-Chloro-3-amino-5-bromopyridine

2-Chloro-3-amino-5-bromopyridine is a key intermediate in the field of organic synthesis. It has a wide range of uses and plays an indispensable role in the preparation of many important compounds.
First, in the field of medicinal chemistry, this compound can be used as a key starting material for the synthesis of a variety of drugs. The ring structure of Gainpyridine is widely present in many drug molecules, and the substituents such as chlorine, amino and bromine give it unique reactivity and chemical properties. Through ingenious organic reactions, it can be gradually converted into drug molecules with specific pharmacological activities. For example, complex drug skeletons can be constructed by substitution reactions with other compounds containing active functional groups, and new drugs for specific diseases can be developed.
Second, in the field of materials science, 2-chloro-3-amino-5-bromopyridine also has important uses. Its reactivity can be used to prepare organic materials with special photoelectric properties. For example, it can be introduced into the structure of polymer materials through a series of reactions to endow the materials with unique electrical and optical properties, so that it can be applied to the fields of organic light emitting diodes (OLEDs), solar cells and other optoelectronic devices to improve the performance and efficiency of the devices.
Furthermore, in the field of pesticide chemistry, this compound can be used as an important intermediate for the synthesis of high-efficiency pesticides. With its structural characteristics and reactivity, pesticide compounds with specific insecticidal, bactericidal or herbicidal activities can be synthesized, providing strong support for pest control in agricultural production.
In short, 2-chloro-3-amino-5-bromopyridine has shown important application value in many fields such as drugs, materials and pesticides, providing key material basis and technical support for the development of related fields.

The synthesis method of 2-chloro-3-amino-5-bromopyridine has been explored by many parties throughout the ages, and here is a brief number of methods.
First, pyridine is used as the starting material. First, pyridine is brominated to selectively introduce bromine atoms into the No. 5 position of the pyridine ring. This step requires fine regulation of the reaction conditions, such as temperature, reaction time, and the type and amount of brominating reagents used, in order to obtain higher yields and selectivity. Commonly used brominating reagents such as bromine are reacted in specific solvents in the presence of appropriate catalysts. After 5-bromopyridine is obtained, chlorination is carried out, and chlorine atoms are introduced into the No. 2 position of the pyridine ring. This chlorination reaction also requires careful selection of chlorination reagents and reaction conditions to achieve the expected target product. Finally, through aminolysis, the No. 3 position is converted into an amino group to obtain 2-chloro-3-amino-5-bromopyridine.
Second, it can be started from other compounds containing pyridine structures. For example, select a suitable substituted pyridine derivative and pass a series of functional group conversion reactions. First, a certain substituent is properly converted to construct the desired positional relationship of chlorine, bromine and amino groups. In this process, a variety of organic reaction types such as nucleophilic substitution, electrophilic substitution, reduction, and oxidation are involved. The sequence of each step needs to be reasonably planned, and the products of each step should be carefully separated and purified to ensure the purity and yield of the final product.
Third, the synthesis strategy of metal catalysis is adopted. Metal catalysts such as palladium and copper are used to catalyze the reaction of specific halogenated pyridine derivatives with amino-containing reagents. Through precise design of the structure of the reaction substrate and selection of appropriate ligands, the effective synthesis of 2-chloro-3-amino-5-bromopyridine is achieved. This method requires precise control of the activity and selectivity of the metal catalyst, as well as the pH and temperature of the reaction system, in order to achieve good synthesis results.

2-Chloro-3-amino-5-bromopyridine is one of the organic compounds. Its physical properties are very important, and it is related to its performance in various chemical processes.
First of all, its appearance is often solid, and the color may be white to light yellow. This color and shape can help chemists identify it during preliminary observation.
As for the melting point, it is about a certain temperature range, and the specific value varies depending on the amount of impurities and measurement conditions. The determination of the melting point is a key means to identify and purify the compound. If the melting point is accurate, it indicates that the purity of the compound is high; if the melting point deviates from the expected, further purification is required.
Solubility is also an important property. In organic solvents, such as common ethanol, dichloromethane, etc., 2-chloro-3-amino-5-bromopyridine exhibits different degrees of solubility. In ethanol, or with a certain solubility, a uniform solution can be formed; in dichloromethane, the solubility may be higher. This solubility characteristic provides an important basis for the selection of solvents in organic synthesis reactions.
In addition, its density is also a specific value. Although the exact value needs to be determined experimentally, the size of the density affects its distribution and mixing in the reaction system.
Furthermore, the volatility of 2-chloro-3-amino-5-bromopyridine is low, and it is not easy to evaporate into gas under normal temperature and pressure. This property makes the experimental operation more convenient and safe, and there is no need to worry too much about its volatilization loss and the safety hazards caused by it.
In summary, the physical properties of 2-chloro-3-amino-5-bromopyridine, such as appearance, melting point, solubility, density and volatility, play an indispensable role in chemical research and practical application. Chemists should explore it in detail to make good use of it.

The stability of the chemical properties of 2-chloro-3-amino-5-bromopyridine is related to many factors. This compound contains chlorine, amino and bromine functional groups, and the functional groups interact with each other, resulting in complex properties.
Chlorine atoms have electron-withdrawing properties, which can reduce the electron cloud density of the pyridine ring and weaken the activity of the electrophilic substitution reaction on the ring. However, the amino group as the power supply group can increase the electron cloud density of the pyridine ring and enhance the activity of the electrophilic substitution reaction on the ring. The two have opposite effects and balance each other.
Bromine atoms also have some electron-withdrawing properties, but the degree of influence on the electron cloud density of the pyridine ring is slightly different from that of chlorine atoms. And bromine atoms can participate in reactions such as nucleophilic substitution, and their existence adds variables to the reactivity of the compound.
From the perspective of spatial structure, the spatial arrangement of each atom and functional group affects the intermolecular force, which in turn affects the stability of the compound. If the steric resistance is large, the intermolecular interaction is suppressed, or it has a certain impact on the stability.
In addition, external conditions such as temperature, humidity, light, etc., also play a role in the stability of 2-chloro-3-amino-5-bromopyridine. High temperature or chemical bond vibration intensifies, making the compound more prone to react and the stability decreases; light or luminescent chemical reaction changes its chemical structure.
In general, the chemical properties of 2-chloro-3-amino-5-bromopyridine are not absolutely stable, and the stability is influenced by its own structure and external conditions. Its stability varies in different environments and reaction systems.

I think what you are asking is that 2-chloro-3-amino-5-bromopyridine is in the market price range. However, the price in the market often changes over time and is influenced by many factors, such as origin, quality, supply and demand, so it is difficult to determine its price.
From time to time, the price of such compounds often varies where chemical reagents are sold. If it is a high-purity product used in scientific research experiments, its price is high. Because of the difficulty of preparation and the complexity of purification, it is valuable. Or it can reach tens or even hundreds of gold per gram.
If it is an ordinary purity for industrial use, the price may be slightly easier due to high demand and wide production scale. However, depending on the amount, buying in bulk can be reduced to a few gold per gram.
However, the market is fickle, and the price changes rapidly. To know the exact price at the moment, it is advisable to consult chemical raw material suppliers, chemical reagent merchants, or browse the relevant chemical product trading platform to get an accurate number to meet your needs.