2-Bromopyridine-3-sulfonyl chloride

2-Bromopyridine-3-sulfonyl chloride is an important compound in organic chemistry. Its physical properties are particularly important and are related to many chemical applications.
This compound is usually in a solid state, and its appearance may be white to light yellow crystalline powder. Looking at its color, it may vary slightly due to the impurities it contains and the preparation conditions. Its melting point is quite critical, but the specific value varies slightly depending on the measurement method and experimental environment, and generally falls within a certain temperature range. Determination of melting point is crucial in identification and purity analysis.
When it comes to solubility, 2-bromopyridine-3-sulfonyl chloride exhibits good solubility in organic solvents such as dichloromethane, chloroform, ether, etc. This property makes it easy to mix with other reactants in organic synthesis reactions to promote the progress of the reaction. However, in water, its solubility is poor, due to the lack of strong interaction groups with water molecules in its molecular structure.
In addition, 2-bromopyridine-3-sulfonyl chloride has a certain volatility. Although its volatility is not as good as that of some low-boiling organic solvents, it will also be partially lost under open system or heating conditions. Therefore, when storing, it should be properly sealed and placed in a cool and dry place to prevent volatilization loss and reaction with air components.
Furthermore, its density is also an important physical parameter. Although the exact density value is affected by factors such as temperature and purity, it is known that its approximate density range is very beneficial in experimental operations, such as weighing and measuring, which can ensure the accuracy and reproducibility of the experiment.
In summary, the physical properties of 2-bromopyridine-3-sulfonyl chloride, including appearance, melting point, solubility, volatility and density, have a significant impact on its application in organic synthesis, analytical chemistry and other fields. When using this compound, chemists must have a thorough understanding of its physical properties in order to achieve the desired experimental results.

The chemical synthesis method of 2-bromopyridine-3-sulfonyl chloride has existed in ancient times, and with the changes of time, many parties have studied it, and the method is also popular.
One method is also to use 2-bromopyridine as the base. To introduce the sulfonyl group first, specific sulfonating reagents such as fuming sulfuric acid or chlorosulfonic acid need to be borrowed. Both of these have strong sulfonation power. Put 2-bromopyridine in an appropriate solvent, such as dichloromethane or chloroform, to make a uniform liquid phase. Slowly drop in the sulfonating reagent, during which the temperature needs to be strictly controlled, because the sulfonation reaction is mostly exothermic, and if the temperature is too high, side reactions will occur. After the sulfonation reaction is completed, the intermediate of 2-bromopyridine-3-sulfonic acid is obtained. Then, to convert the sulfonic acid into sulfonyl chloride, thionyl chloride or phosphorus oxychloride can be used. Both are good agents for chlorination. Add thionyl chloride or phosphorus oxychloride to the above reaction system, and after a little heating, the reaction can be completed, and the product is 2-bromopyridine-3-sulfonyl chloride.
The second method can start from pyridine. First, pyridine and bromine are reacted under appropriate conditions, and bromine atoms can be introduced into the second position of the pyridine ring. The steps of sulfonation and chlorination are similar to those of the previous method, and the target product can also be obtained. In this process, the bromination reaction requires a suitable catalyst and reaction conditions to promote the bromine atom to fall precisely in the second position.
There is another method, using 3-amino-2-bromopyridine as the starting material. After diazotization, the amino group is converted into a diazo salt. Then it is reacted with sodium sulfite to obtain 2-bromopyridine-3-sulfonic acid, and then chlorinated, 2-bromopyridine-3-sulfonyl chloride can also be obtained. The diazotization reaction must be handled carefully at low temperature to prevent the decomposition of diazo salts.
All kinds of synthesis methods have their own advantages and disadvantages. Users should choose carefully according to actual needs, such as the availability of raw materials, the cost, and the purity requirements of the product.

2-Bromopyridine-3-sulfonyl chloride is widely used in the field of organic synthesis. First, it can be used as a key intermediate for the preparation of a variety of nitrogen-containing heterocyclic compounds. If it reacts with nucleophiles, such as amines, alcohols, thiols, etc., new carbon-nitrogen, carbon-oxygen, carbon-sulfur and other chemical bonds can be formed, and then heterocyclic derivatives with diverse structures can be constructed.
When this compound reacts with amine nucleophiles, the amine group will replace the chlorine atom to form 2-bromopyridine-3-sulfonamide derivatives. Such derivatives are of great significance in the field of medicinal chemistry, or have biological activities such as antibacterial, anti-inflammatory, and anti-tumor, providing an important structural basis for the development of new drugs.
interacts with alcohol nucleophiles to generate corresponding sulfonate esters. Sulfonate esters are also important intermediates in organic synthesis, which can further participate in nucleophilic substitution, elimination and other reactions to help build complex organic molecular structures.
Second, 2-bromopyridine-3-sulfonyl chloride is also used in the field of materials science. The specific functional materials prepared from it, or with unique electrical and optical properties, can be used in the research and development of materials such as organic Light Emitting Diodes (OLEDs) and sensors, contributing to the improvement of material properties and functional expansion.
Third, in the field of pesticide chemistry, the products it participates in synthesis may become active ingredients of new pesticides. With its unique chemical structure, it may show high selectivity and high efficiency in inhibiting and killing specific pests and bacteria, providing new ways and methods for agricultural pest control.
In conclusion, the unique activity of bromine atom and sulfonyl chloride group in the structure of 2-bromopyridine-3-sulfonyl chloride is an indispensable and important compound in many fields such as organic synthesis, drugs, materials, and pesticides, and plays a key role in promoting the development of various fields.

2-Bromopyridine-3-sulfonyl chloride is a chemical substance. When storing and transporting it, many key things need to be paid attention to to to ensure that it is safe and protected from loss.
When storing, the first environmental conditions are important. This substance should be stored in a cool, dry and well-ventilated place. Because a cool environment can suppress the rate of chemical reaction that may occur, drying can prevent it from hydrolysis by moisture. The reason is that 2-bromopyridine-3-sulfonyl chloride reacts easily in contact with water, causing it to deteriorate and fail, and even be dangerous. Well-ventilated can disperse small amounts of substances that may leak and prevent them from accumulating to dangerous concentrations.
In addition, storage containers must also be selected carefully. Corrosion-resistant materials, such as glass or specific plastic containers, should be used. Because 2-bromopyridine-3-sulfonyl chloride is corrosive, ordinary materials are prone to erosion and leakage. And the container must be tightly sealed to prevent air and moisture from invading.
When transporting, there are also many precautions. The packaging must be solid and reliable to prevent package damage due to collision and vibration. At the same time, the transportation vehicle needs to be equipped with corresponding emergency treatment equipment and protective equipment to prepare for emergencies such as leaks. Transport personnel should also be professionally trained to be familiar with the dangerous characteristics of 2-bromopyridine-3-sulfonyl chloride and emergency response methods.
In addition, whether it is stored or transported, it must strictly follow relevant laws and regulations and safety standards. Such as correctly posting warning signs to indicate its danger, so that contacts can be aware of it at a glance and be cautious. In this way, 2-bromopyridine-3-sulfonyl chloride can be stored and transported in a safe and orderly manner without causing harm.

2-Bromopyridine-3-sulfonyl chloride is a useful reagent in organic synthesis. However, its market price range is difficult to describe in a word. Many factors will affect its price.
The first to bear the brunt is the difficulty of preparation. The synthesis of this compound may require complicated steps, special raw materials and conditions. If the preparation is difficult, it requires a lot of manpower, material resources and time, and its cost will rise, which will lead to high market prices.
Furthermore, the price of raw materials is also the key. If the supply of raw materials required for the preparation of 2-bromopyridine-3-sulfonyl chloride is scarce or the price fluctuates violently, it will also have a significant impact on its final selling price. If the price of raw materials rises, the price of the product will often rise with it.
In addition, the supply and demand situation of the market should not be underestimated. If there is a period of significant increase in demand for 2-bromopyridine-3-sulfonyl chloride in many industries, and the supply is relatively insufficient, the price will rise; conversely, if there is little demand and excess supply, the price may decline.
In addition, the pricing strategies of different manufacturers also vary. Large factories or due to the scale effect, the cost can be controlled, and the price may be relatively close to the people; while small factories have low production efficiency and high operating costs, the price set may be higher.
Overall, the market price of 2-bromopyridine-3-sulfonyl chloride ranges from tens of yuan per gram to hundreds of yuan or even higher per gram. The fluctuation range is quite large, and it is difficult to accurately define a fixed price range. When purchasing, it is necessary to study the market in detail and compare the quotations of different manufacturers with product quality in order to obtain a suitable choice.