2-Bromopyridine-3-Carboxylic Acid

2-%E6%BA%B4%E5%90%A1%E5%95%B6-3-%E7%BE%A7%E9%85%B8%E4%B8%BB%E8%A6%81%E7%94%A8%E9%80%94%E4%B8%89%E7%82%B9%EF%BC%9A
First, it is quite useful in the matter of alchemy and pharmaceuticals. Ancient alchemists made alchemy and wanted the medicine of longevity, and these two things were often the key materials. Such as Ge Hong and other alchemists, on the side of the pill furnace, based on lead and mercury, borax can help its fusion and change, realgar can also add its magical effect, in the lingering pill smoke, borax and realgar play a role in promoting the wonderful chemical transformation of drugs, helping alchemists pursue the ethereal secret of longevity.
Second, it is indispensable in traditional Chinese medicine to treat diseases and save people. Borax is cold, can clear away heat and detoxify, reduce swelling and prevent corrosion, and is often used for sores on the mouth and throat, sore throat and other diseases. Realgar has the effect of detoxification and insecticide, dryness and dampness to remove phlegm, and has many curative effects on scabies, snake bites, malaria and other diseases. Doctors use its unique medicinal properties to combine various medicines to treat diseases and diseases for patients. In case of the disease of poisonous sores and carbuncle, or add borax to the medicine to reduce swelling, or add realgar to detoxify, so that the patient gradually recovers.
Third, it is also wonderfully used in ancient crafts. In the process of ceramic firing, borax can be used as a flux to reduce the firing temperature, making the ceramic texture more uniform and delicate, and the color is more radiant. In the blending of certain pigments, realgar can provide a unique color, adding a different color to painting, lacquer ware and other crafts, making the utensils appear simple and gorgeous, witnessing the exquisite craftsmanship of ancient times over the years.

To prepare dipentyne and triheptyl acid, there are various methods, which are described in detail as follows.
To produce dipentyne, the reaction of dehalogenation is often carried out by co-heating 1,2-dibromopentane with a strong base. For example, by co-heating 1,2-dibromopentane with an alcohol to make potassium hydroxide, the reaction goes through two steps, first removing one molecule of hydrogen bromide to form bromopentene, and then removing one molecule of hydrogen bromide to obtain dipentyne. The reaction formula is as follows:
\ (CH_ {3} CH_ {2} CHBrCHBrCH_ {3} + 2KOH\ xrightarrow [] {alcohol,\ triangle} CH_ {3} CH_ {2} C\ equiv CCH_ {3} + 2KBr + 2H_ {2} O\)
Sodium acetylene can also be reacted with bromoethane. Propylene first reacts with sodium metal to obtain sodium propylene, and then replaces with bromoethane nucleophilic to obtain dipentyne. The reaction is as follows:
\ (CH_ {3} C\ equiv CH + Na\ xrightarrow [] {} CH_ {3} C\ equiv CNa +\ frac {1} {2} H_ {2}\ uparrow\)
\ (CH_ {3} C\ equiv CNa + CH_ {3} CH_ {2} Br\ xrightarrow [] {} CH_ {3} C\ equiv CCH_ {2} CH_ {3} + NaBr\)
As for the synthesis of triheptyl acid, one method is to hydroformylate 1-hexene with carbon monoxide and water under the action of a catalyst to obtain heptyl aldehyde, and then oxidize to obtain triheptyl acid. The reaction formula is:
\ (CH_ {2} = CH (CH_ {2}) _ {3} CH_ {3} + CO + H_ {2} O\ xrightarrow [] {catalyst} CH_ {3} (CH_ {2}) _ {5} CHO\)
\ (CH_ {3} (CH_ {2}) _ {5} CHO + [O]\ xrightarrow [] {} CH_ {3} (CH_ {2}) _ {5} COOH\)
can also use n-hexanol as raw material, first oxidized to n-hexanal, and then further oxidized to n-hexanoic acid. Under the catalysis of red phosphorus, the Hell-Volhard-Zelinsky reaction between n-caproic acid and bromine occurs, and α-hydrogen is replaced by bromine to obtain α-bromohexanoic acid. After reacting with basic reagents such as sodium glycol, triheptyl acid can be obtained by hydrolysis and acidification. The series of reactions are as follows:
\ (CH_ {3} (CH_ {2}) _ {4} CH_ {2} OH + [O]\ xrightarrow [] {} CH_ {3} (CH_ {2}) _ {4} CHO\)
\ (CH_ {3} (CH_ {2}) _ {4} CHO + [O]\ xrightarrow [] {} CH_ {3} (CH_ {2}) _ {4} COOH\)
\ (CH_ {3} (CH_ {2}) _ {4} COOH + Br_ {2}\ xrightarrow [] {red phosphorus} CH_ {3} (CH_ {2}) _ {3} CHBrCOOH\) < Br >\ (CH_ {3} (CH_ {2}) _ {3} CHBrCOOH + C_ {2} H_ {5} ONa\ xrightarrow [] {} [CH_ {3} (CH_ {2}) _ {3} CH (OC_ {2} H_ {5}) COOH]\ xrightarrow [] {H_ {2} O, H ^ {+}} CH_ {3} (CH_ {2}) _ {3} CH (OH) COOH\), triheptyl acid can be obtained by rearrangement and other processes.
The above methods have their own advantages and disadvantages. The experiment needs to be based on the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the high and low yield.

2-%E6%BA%B4%E5%90%A1%E5%95%B6, 3-%E7%BE%A7%E9%85%B8%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8%E6%9C%89%E5%93%AA%E4%BA%9B? Both of these are strange things in the world, with many unique physical properties.
2-%E6%BA%B4%E5%90%A1%E5%95%B6, the appearance is often crystal clear, clear and transparent, like the glaze of heaven. Its texture is warm and moist, and it has a trace of coolness to the touch, just like the clear spring flowing in the palm of the mountain. Fluidity is very good, you can change the form at will, when you meet the square, when you meet the circle, it is round, and there is no fixed shape, just like the Taoist saying "the best is like water, water is good for all things and does not fight", and it is shaped according to the situation. And it has good solubility, many substances can be dissolved in it, and it seems to have endless inclusive power, which can fuse all things without losing its authenticity.
As for 3-%E7%BE%A7%E9%85%B8%E7%9A%84, it is often in the state of powder, white as snow, delicate and uniform. Its texture is light, and it seems to float up when the breeze blows. It is insoluble in water, but it can react wonderfully with other substances under specific circumstances. When heated, it may produce unique changes, or expand, or change color, showing a different kind of magic. Its chemical properties are relatively stable, and when it encounters suitable reagents, it can also rejuvenate, participate in various chemical reactions, and generate new substances. It is like a guru hidden in the world. When the time is ripe, it will show its extraordinary ability.
Both of these, whether they are agile and inclusive like water, or calm and changeable like powder, are unique in the world due to their unique physical properties, which makes people sigh at the wonders of creation and the infinite mysteries of nature.

In today's market, the two-dimensional and three-dimensional patterns are determined by people. These two are in the market, and their effects are affected by the economy of supply and demand.
The two-dimensional factor, with the two-dimensional factor, is slightly lower. However, because of its low cost, it is also useful in some small transactions and private circulation. If there is a shortage of sources in the market, and the demand for transactions is complex, the two-dimensional factor may not be able to circulate. In this case, its performance may be slightly reduced, but it is also better than the other. It's about two times per hundred, and it's worth about 30 or 40 words. However, it is still different in various places.
As of three years, the material used is not a good thing. It's easy to use, it can last for a long time, and it's worth it. The city people are mostly due to its suitability, or it is prevalent in private affairs, mixed with systems, and occasionally circulates. Its price is 20%, and it is also higher. Usually, under the circumstances, it is three times per hundred words, and the value is 20 or 30 words. And because of its inferiority, it is used for private transactions by many people, and the degree of official approval is low.
Of course, two, three, and three are not the right way to control, and there is also a fixed price for the market. There are many situations that are born, and when the system is completed, it will be lower or worse.

2-%E6%BA%B4%E5%90%A1%E5%95%B6, 3-%E7%BE%A7%E9%85%B8%E7%9A%84%E5%82%A8%E5%AD%98%E6%9D%A1%E4%BB%B6%E5%85%B7%E4%BD%93%E5%A6%82%E4%B8%8B:
Where 2-%E6%BA%B4%E5%90%A1%E5%95%B6 or 3-%E7%BE%A7%E9%85%B8 are hidden, you must choose a high and dry place, and build soil as a platform, and surround the platform with ditches to prevent rain. The platform is about two feet high, covered with tiles, and windows and windows are opened on all sides to pass air. The interior is divided into small rooms, the size of the room depends on the amount of hiding. The interior is set up, and the shelves are made of wood, and they are piled up on layers for display. What is hidden should be inspected at ordinary times, so that it should not be damp and moldy, and it should not be eaten by insects and rats. If there is any damage, it should be repaired in time. The door of the storeroom should be locked at ordinary times, and those who are not in charge of the collector should not enter. In this way, 2-%E6%BA%B4%E5%90%A1%E5%95%B6, 3-%E7%BE%A7%E9%85%B8%E5%8F%AF%E4%BF%9D%E5%AD%98%E5%8E%9F%E7%89%B9, and it will not be damaged for a long time.