2-Bromopyridine-3-Carboxaldehyde

2-Bromopyridine-3-carboxaldehyde (2-Bromopyridine-3-carboxaldehyde) has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. The special structure of the genopyridine ring and the bromine atom and aldehyde group endows it with various reactive activities and can participate in various organic reactions, such as nucleophilic substitution and condensation, which lays the foundation for the synthesis of characteristic drug molecules. Taking the synthesis of an antibacterial drug as an example, this compound builds a key pharmacodynamic structure and achieves antibacterial activity by condensing the aldehyde group with a specific amine and then substituting the nucleophilic at the bromine atom.
It is also useful in the field of materials science. Due to its conjugate properties and reaction check points, it can be introduced into polymer systems through specific reactions to change the photoelectric properties of materials. For example, by reacting with polymers containing specific functional groups, materials with special optical properties are prepared, which are used in the field of organic Light Emitting Diodes (OLEDs) or light sensors. The luminescence or sensing properties of materials are regulated by their structural properties.
In organic synthetic chemistry, it is an important starting material for the construction of complex pyridine derivatives. Chemists build a multi-structural skeleton by selectively modifying its bromine atom and aldehyde group. For example, by using the classical reactions of aldehyde groups, such as Wittig reaction and Mannich reaction, the carbon chain is extended or heteroatomic groups are introduced, and complex organic molecules with unique functions are created through multi-step reactions, which contribute to the development of organic synthetic chemistry.

The synthesis method of 2-bromopyridine-3-formaldehyde has been used by many parties throughout the ages. One commonly used method is to use pyridine-3-formaldehyde as the starting material. First, place pyridine-3-formaldehyde in a suitable reaction vessel, add an appropriate amount of solvent, such as dichloromethane, to fully dissolve it to form a uniform solution. Then, under low temperature and stirring conditions, slowly add brominating reagents, such as N-bromosuccinimide (NBS). This process requires close monitoring of the reaction temperature to prevent side reactions from occurring. After the dropwise addition is completed, continue to stir for a period of time to allow the reaction to proceed fully. After the reaction is completed, a series of post-treatment operations such as extraction, washing, drying, column chromatography, etc., pure 2-bromopyridine-3-formaldehyde can be obtained.
In addition, there are also those who use 2-aminopyridine-3-formaldehyde as the starting material. First, 2-aminopyridine-3-formaldehyde is reacted with an appropriate amount of sodium nitrite and inorganic acid (such as hydrochloric acid) at low temperature to form diazosalt. Subsequently, cuprous bromide (CuBr) is added as a catalyst, and the diazonium salt undergoes a Sandmeyer reaction, which realizes the substitution of amino groups by bromine atoms to generate 2-bromopyridine-3-formaldehyde. After the reaction, a series of separation and purification steps are also required to obtain high-purity products.
Another method is to synthesize pyridine derivatives through multi-step reactions. First, the specific position of the pyridine derivative is functionalized, and suitable substituents are introduced, and then the structure of the target molecule is gradually constructed through halogenation and oxidation reactions. Although this method is a little complicated, it is also a good solution for specific needs or limited raw materials. Each method has its own advantages and disadvantages, and it is necessary to choose carefully according to the actual situation, such as the availability of raw materials, cost, yield and purity requirements.

2-Bromopyridine-3-formaldehyde, this is an organic compound. Its physical properties are quite critical, and it has far-reaching influence in many fields such as chemical industry and pharmaceutical synthesis.
Looking at its properties, under room temperature and pressure, it mostly shows a light yellow to yellow solid state, with a fine texture, like dust deposited over time. Its melting point is about 62-66 ° C, just like the temperature at which the critical ice and snow melt in the warm sun in spring. Under a specific heat energy, the state of matter quietly changes. The boiling point is about 294.1 ° C. At higher temperatures, it can be turned into a gaseous state, like a phoenix nirvana, and it needs to be sublimated by fire.
Solubility is also an important property. This compound in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), just like fish get water, has good solubility, can be uniformly dispersed in it, just like water-emulsion blending, providing convenient conditions for organic synthesis reactions. However, its solubility in water is poor, like oil and water, it is difficult to blend, this characteristic can be used in the process of separation and purification.
2-bromopyridine-3-formaldehyde has a density of about 1.673g/cm ³, which is heavier than common water. It is like a heavy history and has its own unique weight. This density parameter is crucial in the material measurement and reaction system design of chemical production. Its vapor pressure has a corresponding value at a specific temperature. Although the state of vapor is difficult to observe with the naked eye, its impact on the reaction environment should not be underestimated, which is related to the kinetic and thermodynamic balance of the reaction.
In summary, the melting point, boiling point, solubility, density and vapor pressure of 2-bromopyridine-3-formaldehyde lay the foundation for its application in scientific research and industrial production. It is like a precise map that guides chemists and engineers to explore the mysteries of material transformation.

2-Bromopyridine-3-formaldehyde, this is an organic compound with unique chemical properties. It contains bromine atoms and aldehyde groups, which are widely used in the field of organic synthesis.
First of all, its physical properties are mostly solid or liquid at room temperature, but the specific state varies according to environmental conditions. Its melting point and boiling point are related to intermolecular forces and relative molecular weight. Because the molecule contains polar groups, it has good solubility in polar solvents such as ethanol and acetone, but poor solubility in non-polar solvents such as n-hexane.
In terms of chemical properties, aldehyde groups have high activity. Oxidation reaction can occur. When encountering common oxidants such as potassium permanganate and potassium dichromate, they can be oxidized to the corresponding carboxylic acid, namely 2-bromopyridine-3-carboxylic acid. This is an important way to prepare pyridine carboxylic acids.
At the same time, aldehyde groups can participate in the reduction reaction. Using sodium borohydride, lithium aluminum hydride, etc. as reducing agents, they can be reduced to 2-bromopyridine-3-methanol, which is commonly used in the preparation of hydroxypyridine derivatives.
Furthermore, aldehyde groups can carry out nucleophilic addition reactions. Acetal can be formed with alcohols under acid catalysis. When reacted with ammonia and its derivatives, nitrogen-containing heterocyclic compounds can be formed, which is of great significance for the construction of complex pyridine compounds.
And bromine atoms are also active and can undergo substitution reactions. Under suitable conditions, they can be replaced by hydroxyl groups, amino groups, cyano groups, etc., to realize the conversion of groups on the pyridine ring, and to synthesize pyridine derivatives with diverse structures.
In addition, the pyridine ring of 2-bromopyridine-3-formaldehyde is aromatic and can undergo electrophilic substitution reactions. Because of the substituents such as bromine atoms and aldehyde groups on the ring, the localization effect is complex, and the reaction conditions and product distribution need to be analyzed in detail.
In summary, 2-bromopyridine-3-formaldehyde has active chemical properties and is an important intermediate in the fields of organic synthesis and medicinal chemistry, providing an effective path for the preparation of many organic compounds.

The price of 2-bromopyridine-3-formaldehyde in the market is difficult to determine. The change in its price is related to many ends.
First, the amount is very important. If the purchase quantity is huge, the seller may give the best price due to economies of scale. If the volume is produced, the cost may drop, and the buyer can make a profit. However, if the demand is small, the price may be high, so the seller needs to make up the cost of small transactions.
Second, the place of origin also has an impact. Different origins, due to the price of raw materials, labor costs, and taxes, the cost of this thing is different. And the distance of transportation also increases its cost.
Third, the change of the situation cannot be ignored. The supply and demand of the city are changing rapidly. If there are many people who need it, but there are few producers, the price will rise. On the contrary, if the supply exceeds the demand, the price will go down. And the new regulations of the chemical industry, changes in raw materials, natural and man-made disasters, etc., can cause the price to fluctuate.
Fourth, the quality is high or low, also depends on the price. High purity, high quality 2-bromopyridine-3-formaldehyde, because of the need for fine research and strict supervision of quality, the price must be higher than ordinary ones. Buyers should also review its quality when they are at the price, not only ask for a low price.
Therefore, if you want to know the exact price of this item, you should consult the merchants and specify the required quantity and quality in detail before you can obtain a more accurate quotation. And it is appropriate to observe the dynamics of the market and show the trend of the price.