2 Bromomethyl 5 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2-(Bromomethyl)-5-(trifluoromethyl)pyridine

    Specifications

    HS Code

    269968

    Chemical Formula C7H5BrF3N
    Molecular Weight 240.02
    Appearance Solid (Typical)

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    General Information
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    Frequently Asked Questions

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    What is the main use of 2- (Bromomethyl) -5- (trifluoromethyl) pyridine?
    2-%28Bromomethyl%29-5-%28trifluoromethyl%29pyridine is 2- (bromomethyl) -5- (trifluoromethyl) pyridine, which has a wide range of uses. In the field of pharmaceutical synthesis, it is often used as a key intermediate to help create many special drugs. Because of its unique chemical structure, it can cleverly react with other compounds to derive molecules with specific pharmacological activities, or it can be used in the development of anti-cancer drugs to precisely act on specific targets of cancer cells to curb the proliferation and spread of cancer cells; or in the field of antiviral drug development, with its structural characteristics, it can effectively block the key link of virus replication and open up new paths for antiviral therapy.
    In the field of materials science, 2- (bromomethyl) -5- (trifluoromethyl) pyridine also has important uses. It can participate in the preparation of functional polymer materials, giving materials such as special optical and electrical properties. For example, the preparation of photoluminescent materials emits unique optical signals under specific conditions, making great use in the field of optical sensors to achieve sensitive detection of specific substances or physical quantities. It can also be used to synthesize conductive polymers with special electrical properties, making a name for themselves in electronic devices such as organic field effect transistors, improving device performance and stability.
    In organic synthesis chemistry, 2- (bromomethyl) -5- (trifluoromethyl) pyridine is an extremely useful building block. With the reactivity of bromomethyl and trifluoromethyl, through various organic reactions, such as nucleophilic substitution, coupling reaction, etc., complex and diverse organic compounds are constructed, which greatly enriches the molecular library of organic compounds and injects vitality into the development of organic synthesis chemistry.
    What are the synthesis methods of 2- (Bromomethyl) -5- (trifluoromethyl) pyridine
    To prepare 2- (bromomethyl) -5- (trifluoromethyl) pyridine, the method of organic synthesis is often followed. There are two ways. One is to use 5- (trifluoromethyl) pyridine-2-methanol as the starting material to heat with hydrobromic acid. After substitution, the hydroxyl group is replaced by a bromine atom, and then the target product is obtained. This reaction needs to be carried out at an appropriate temperature and reaction time to achieve a considerable yield. However, attention should be paid to the generation of side reactions during the reaction, such as elimination reactions, etc. The reaction conditions, such as temperature and acid concentration, can be adjusted to reduce the influence of side reactions.
    The second method is to use 5- (trifluoromethyl) pyridine as the base, first introduce the protective group, the specific position of the protective pyridine ring, and then use a halogenated reagent, such as N-bromosuccinimide (NBS), with the help of light or initiator, carry out a bromination reaction to make methyl bromide, and then obtain 2- (bromomethyl) -5- (trifluoromethyl) pyridine. In this process, the protective group is very important, which needs to be easy to introduce, easy to remove, and stable under the reaction conditions. The step of deprotecting the group after the reaction also needs to be carefully handled to ensure the purity and yield of the product.
    No matter what method, after the reaction is completed, it needs to go through separation and purification processes, such as extraction, distillation, column chromatography, etc., to obtain pure 2- (bromomethyl) -5- (trifluoromethyl) pyridine. These methods have their own advantages and disadvantages, and the implementation needs to be weighed according to the availability of raw materials, cost, yield and other factors.
    What are the physical properties of 2- (Bromomethyl) -5- (trifluoromethyl) pyridine
    2-%28Bromomethyl%29-5-%28trifluoromethyl%29pyridine, the Chinese name may be 2- (bromomethyl) -5- (trifluoromethyl) pyridine. The physical properties of this substance are worth exploring.
    Looking at its shape, it is mostly liquid at room temperature and pressure. Its color may be nearly colorless, or slightly yellow, clear and clear, and there is no turbidity.
    As for the boiling point, the molecular structure contains bromine atoms and trifluoromethyl, resulting in complex intermolecular forces. It is speculated that the boiling point should be within a certain range, because the bromine atom increases the molecular mass and intermolecular forces, and the strong electron-absorbing property of trifluoromethyl also affects it, which is about 100 degrees Celsius, but the exact value needs to be determined experimentally and accurately.
    In terms of melting point, affected by the above groups, the molecular arrangement order changes, the melting point is low or lower, and it is in the relatively low temperature range, about several degrees Celsius below zero, which also needs to be confirmed by experiments.
    In terms of solubility, because its pyridine ring has a certain polarity, and the characteristics of bromomethyl and trifluoromethyl, it may exhibit good solubility in organic solvents. Organic solvents such as common ethanol, ether, and dichloromethane are compatible with them. In water, due to limited polarity, solubility or poor solubility, it is not completely insoluble, or there is a slight solubility.
    The density is higher than that of water or slightly larger. Due to the large relative atomic mass of bromine atoms in the molecule, its unit volume mass is heavier.
    The vapor pressure of this substance is relatively low at room temperature, and due to the relatively strong intermolecular forces, the tendency of molecules to escape from the liquid surface to form steam is weak.
    In summary, the physical properties of 2- (bromomethyl) -5- (trifluoromethyl) pyridine are unique due to the synergistic action of various groups in the molecular structure. However, many properties still need to be carefully investigated by experiments to obtain accurate numbers.
    2- (Bromomethyl) -5- (trifluoromethyl) pyridine what to pay attention to when storing and transporting
    2-%28Bromomethyl%29-5-%28trifluoromethyl%29pyridine are organic compounds, and many matters need to be paid attention to when storing and transporting them.
    When storing, choose the first environment. It must be placed in a cool, dry and well-ventilated place, away from high temperature and humidity. This high temperature can easily cause the compound to react or decompose, and the humid environment may cause adverse reactions such as hydrolysis, resulting in damage to its quality.
    Furthermore, it should be kept away from fires, heat sources and oxidants. Because of its certain chemical activity, it may be dangerous to burn or explode when exposed to open flames, hot topics or oxidants.
    The choice of storage container is also crucial. A well-sealed container is required to prevent it from evaporating or reacting with components in the air. In general, containers made of glass or specific plastic materials are more suitable, but the compatibility of the material with the compound needs to be considered to prevent the container from being corroded.
    When transporting, be sure to operate in accordance with relevant regulations and standards. The packaging needs to be sturdy to ensure that there is no leakage during transportation. And the transportation vehicle should be equipped with fire extinguishing equipment and emergency treatment equipment to prepare for emergencies.
    Transportation personnel also need to be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods. During transportation, they should be protected from sun, rain and high temperature, drive according to the specified route, and do not stop in densely populated areas or important places.
    In short, 2-%28Bromomethyl%29-5-%28trifluoromethyl%29pyridine storage and transportation need to be strictly operated, paying attention to the environment, containers, regulations and many other aspects to ensure its stability and safety.
    2- (Bromomethyl) -5- (trifluoromethyl) pyridine market prospects
    2-%28Bromomethyl%29-5-%28trifluoromethyl%29pyridine is 2- (bromomethyl) -5- (trifluoromethyl) pyridine. The market prospect of this product is related to the application and development trend in many fields.
    In the field of medical chemistry, due to its unique structure, containing bromomethyl and trifluoromethyl, it endows molecules with special physical and biological activities, or becomes a key building block for the creation of new drugs. Nowadays, there is a growing demand for active novel compounds in pharmaceutical research and development. With its unique structure, it may emerge in the process of drug development, bringing opportunities for the development of new drugs against many diseases, and there is a broad potential space in the pharmaceutical market.
    In the field of materials science, with the increase in demand for high-performance materials, this compound can be used as a raw material for the construction of special functional materials. The functional groups contained in it can participate in specific chemical reactions and prepare materials with unique optoelectronic and thermal stability properties. For example, they are applied to organic optoelectronic materials, polymer material modification and other fields, and are expected to gain a place in the materials market.
    However, its market prospects are also facing challenges. Synthesis of this compound may require complex steps and specific conditions, and the cost may be high, limiting large-scale application. And the market competition is fierce. If you want to stand out, you need to make efforts in synthesis process optimization and cost control.
    In summary, although 2- (bromomethyl) -5- (trifluoromethyl) pyridine has considerable market potential, it is necessary to overcome problems such as synthesis costs and seize development opportunities in the fields of medicine and materials in order to occupy a favorable position in the market.