2-BROMO-6-TERT-BUTYLPYRIDINE

2-Bromo-6-tert-butylpyridine is one of the organic chemicals. It has a wide range of uses and has important applications in many fields.
In the field of drug synthesis, it is often used as a key intermediate. The structure of the Geinpyridine ring is crucial in many drug molecules. The bromine atom and tert-butyl group of 2-bromo-6-tert-butylpyridine can be introduced into other specific groups through a series of organic reactions, such as nucleophilic substitution reactions, to build complex drug molecules. For example, in the development of some antibacterial drugs, their structural properties are used to synthesize target compounds with antibacterial activity through specific reaction steps, providing key starting materials for drug creation.
In the field of materials science, it also has outstanding performance. It can participate in the preparation of organic materials with special properties. For example, by polymerizing with other monomers, its structural units are introduced into the main chain or side chain of the polymer, giving the polymer unique electrical, optical or thermal properties. For example, when preparing conjugated polymer materials with specific photoelectric properties, 2-bromo-6-tert-butylpyridine, as a functional monomer, participates in the polymerization reaction, so that the obtained materials are expected to be applied to organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices to improve device performance.
Furthermore, in the field of organic synthetic chemistry research, it is a commonly used synthetic block. Chemists use its unique chemical activity and structural characteristics to carry out various novel reaction studies. By exploring new reaction paths, efficient construction of complex organic molecules can be achieved, promoting the development of organic synthesis methodologies, and contributing to the expansion of knowledge system and technological innovation in the field of organic chemistry.

To prepare 2-bromo-6-tert-butylpyridine, there are many methods, and the following are common ones.
First, 6-tert-butylpyridine is used as the starting material and prepared by bromination reaction. This process often requires adding a brominating reagent in an appropriate solvent, such as dichloromethane and other inert solvents. The brominating reagent can be selected from bromine (Br ²), but bromine is highly corrosive and toxic, and the operation needs to be cautious. In order to make the reaction more controllable, N-bromosuccinimide (NBS) can also be used as a brominating agent. During the reaction, it is often necessary to add an initiator, such as benzoyl peroxide (BPO) or light to initiate a free radical reaction. On the pyridine ring of 6-tert-butyl pyridine, because the tert-butyl group is an ortho-site group and the steric barrier is large, the bromine atom is easier to replace the tert-butyl ortho-site, that is, the 2-position, so as to obtain the target product 2-bromo-6-tert-butyl pyridine.
Second, the pyridine derivative is used as the starting material and prepared by a multi-step reaction. The tert-butyl group is introduced into the pyridine ring at a suitable position first, and the tert-butyl chloride is commonly used as a tert-butyl chloride ((CH) < CCl). Under the catalysis of Lewis acids such as aluminum trichloride (AlCl), the Friedel-Crafts alkylation reaction occurs, and the tert Subsequently, bromine atoms are introduced at specific positions through bromination reaction. Although this approach has many steps, the reaction sequence and conditions can be flexibly adjusted according to needs to improve product selectivity and yield.
Or start from natural products or other compounds containing pyridine structures, and gradually build 2-bromo-6-tert-butylpyridine structures through a series of functional group transformation and modification. However, this approach is often used relatively rarely due to limited raw material sources and cumbersome reaction steps. In conclusion, the synthesis of 2-bromo-6-tert-butylpyridine should be based on the actual situation, considering factors such as raw material availability, cost, reaction conditions and product purity, and selecting an appropriate synthesis method.

2-Bromo-6-tert-butylpyridine is an important compound in organic chemistry. It has unique physical properties and is widely used in the field of chemical synthesis.
Looking at its appearance, 2-bromo-6-tert-butylpyridine is a colorless to light yellow liquid at room temperature and pressure, which makes operation and observation more convenient. Due to the good fluidity of the liquid, it is easy to fully contact with other reactants in the reaction system, which promotes the efficient progress of the reaction.
When it comes to the boiling point, the boiling point of 2-bromo-6-tert-butylpyridine is quite high, about 235-237 ° C. A higher boiling point means that the substance can still remain liquid at relatively high temperatures, with strong stability. In chemical reactions that require higher temperatures, it can exist stably and will not quickly vaporize and escape the reaction system due to temperature increase, ensuring the smooth development of the reaction.
Besides the melting point, its melting point is about -10 ° C. This lower melting point indicates that the compound is prone to liquid state near room temperature, further confirming its good fluidity under conventional conditions and providing convenience for various chemical reactions.
2-Bromo-6-tert-butylpyridine has a density of about 1.23 g/mL. The density reflects the mass per unit volume of the substance, and this value allows us to understand its distribution in the reaction system. When mixed with other substances, its position in the system can be judged according to the density difference, which is of great significance for predicting the reaction process and product distribution.
In addition, 2-bromo-6-tert-butylpyridine is slightly soluble in water, but easily soluble in most organic solvents, such as ethanol, ether, dichloromethane, etc. This solubility characteristic lays the foundation for its application in organic synthesis. By selecting a suitable organic solvent, the reaction environment can be precisely controlled, so that the reaction can occur efficiently in a suitable medium, and the reaction selectivity and yield can be improved.

When storing 2-bromo-6-tert-butylpyridine, many matters need to be paid attention to. This material has certain chemical activity and is the first environmental factor. It should be stored in a cool, dry and well-ventilated place to prevent moisture and temperature fluctuations from causing deterioration. High temperature may cause its volatilization to accelerate, or even induce chemical reactions; humid environment is prone to adverse reactions such as hydrolysis, which will damage its quality.
Furthermore, it is necessary to pay attention to the integrity of the package. The package must be tight to avoid contact with air, moisture, etc. If the package is damaged, not only the product quality will be damaged, but also there will be safety hazards, because it may react with external substances to produce harmful substances.
In addition, the storage area should be kept away from fire sources, heat sources and strong oxidants. 2-Bromo-6-tert-butylpyridine may be flammable. In case of open flame and hot topic, it is easy to cause combustion and explosion; in contact with strong oxidants, it may also trigger violent reactions.
At the same time, do a good job of marking management. Mark clearly on the prominent part of the storage container, such as name, specification, storage date, etc., in order to access and manage, and to avoid the risk of misuse.
During the storage process, regular inspection is also indispensable. Observe whether the packaging is abnormal and the product shows no signs of deterioration, detect and deal with potential problems in time, and ensure that the quality of 2-bromo-6-tert-butylpyridine is stable and safe during storage.

2-Bromo-6-tert-butylpyridine, the price range of this product in the market often varies due to various reasons. If you look at the methods of things described in "Tiangong Kaiwu" in the past, the price of the product is related to the origin, supply and demand, and production methods.
As far as the origin is concerned, if it is produced here, near the water tower, its price is cheap; if it comes from far away, plus freight and other fees, the price will increase.
The way of supply and demand is also the main reason. If there are many people in the market, but there are few people in supply, the so-called thing is rare and expensive, and its price should be high; on the contrary, if the supply exceeds the demand, the price will decrease.
The production method is difficult and easy, and it also depends on the price. If the production method is complicated and requires a lot of labor and materials, the cost will be high, and the price will not be low if it is in the market; if the production method is simple, the cost will drop, and the price will also go down.
According to the examples of various things in the past, the market price of 2-bromo-6-tert-butylpyridine is between tens and hundreds of yuan per gram. However, this is only a rough number, and the actual price varies from time to time according to the situation, so it cannot be limited to this. To know the exact price, you need to consult the merchants and vendors in the market in detail before you can get it.