2-bromo-6-(methylsulfonyl)pyridine

To prepare 2-hydroxy- 6 - (methylthiazolyl) pyridine, the method is as follows:
First take a suitable reaction vessel, wash and dry it to ensure an anhydrous and oxygen-free environment. Prepare the required raw materials, such as pyridine derivatives containing corresponding substituents, reagents containing methylthiazolyl, and necessary catalysts and solvents.
With common organic synthesis paths, the target compound can be constructed by nucleophilic substitution reaction. Add the pyridine derivative to the methylthiazolyl reagent in an appropriate molar ratio, such as 1:1.2 - 1:1.5, into the reaction vessel. The selected solvent needs to have good solubility to the reactants and does not have side reactions with the reactants, such as dichloromethane, N, N-dimethylformamide, etc.
Add an appropriate amount of catalyst, such as some metal salt catalysts or organic base catalysts, depending on the specific reaction mechanism. The amount of catalyst is usually 0.05-0.2 equivalents of the total amount of reactants. React at a suitable temperature, the reaction temperature may be between 40-80 ° C, and the temperature is precisely controlled through an oil or water bath. During the reaction process, a stirring device is required to keep the reactants fully mixed and contacted to promote the reaction.
The reaction time depends on the reaction process, generally ranging from a few hours to ten hours. During this period, the progress of the reaction can be monitored by thin-layer chromatography (TLC). When the raw material point basically disappears and the new product point does not change, the reaction is regarded as basically completed.
After the reaction is completed, the reaction liquid is cooled to room temperature. If there are solids precipitated in the reaction system, the solids can be collected by filtration; if it is a homogeneous solution, an extraction operation is required. With a suitable organic solvent, such as ethyl acetate, ether, etc., the reaction liquid is extracted multiple times to separate the organic phase.
The organic phase is dried with anhydrous sodium sulfate or magnesium sulfate to remove the moisture in it. After that, the organic solvent is removed by reduced pressure distillation to obtain a crude product. The crude product can be further purified by column chromatography. Appropriate silica gel column and eluent, such as petroleum ether and ethyl acetate mixed in a certain proportion, the fraction containing the target product is collected, and the eluent is removed by rotary evaporation to obtain pure 2-hydroxy- 6-methylthiazolyl) pyridine.

2-% hydroxyl-6- (methylthiazolyl) pyridine is an organic compound with interesting physical properties. From the perspective of "Tiangong Kaiwu", the following analysis can be made:
This substance may be a solid under normal conditions. Looking at its molecular structure, atoms are connected by specific chemical bonds, resulting in a certain crystal structure and morphology. Its melting point and boiling point are influenced by intermolecular forces. Due to the type, number and connection method of atoms in the molecule, a specific force pattern is formed, giving the substance a specific melting and boiling point.
In terms of solubility, according to the principle of similar miscibility, if 2-% hydroxyl-6- (methylthiazolyl) pyridine has a polar group, or has a certain solubility in polar solvents such as water and alcohol; if the molecule is more non-polar, it is more soluble in non-polar organic solvents, such as benzene, carbon tetrachloride, etc.
Its density is also closely related to the molecule, and the molecular weight and the degree of packing compactness determine the density of the substance. Under the same conditions, it can be compared with the density of other common substances to clarify its density characteristics.
In addition, in appearance, it may be white to light yellow powder or crystalline, which is a common appearance of many organic compounds, and the specific color is related to purity and crystal form.
Odor, because it contains specific functional groups or has a unique odor, the exact odor needs to be determined by actual smelling, and the odor intensity is affected by the volatility of the substance and the sensitivity of human olfaction.
In addition, the physical properties of 2-% hydroxyl-6- (methylthiazolyl) pyridine are of great significance for its application in chemical industry, medicine and other fields. For example, the melting point and boiling point are related to its separation, purification and storage conditions; the solubility affects its dispersion in the reaction system and the degree of participation in the reaction; the density also has reference value in the preparation and measurement.

2-% hydroxyl-6- (methylsulfonyl) pyridine, its chemical properties are as follows:
This compound is weakly acidic, because the hydrogen atoms in the hydroxyl group can be partially ionized, although its acidity is weak, however, in a specific alkaline environment, acid-base reactions can occur, hydroxy hydrogen dissociates, and corresponding negative ions are formed.
The methylsulfonyl group it contains makes the substance have a certain polarity. This polarity affects its solubility. In polar solvents such as water, it has a certain solubility, and can interact with water molecules to form hydrogen bonds and improve solubility.
In redox reactions, the valence state of sulfur in methylsulfonyl groups is variable. In case of strong oxidants, sulfur can be further oxidized and its valence state increases, such as sulfonic acid groups that can be oxidized to higher valence states. On the contrary, in case of strong reducing agents, the sulfur valence state may decrease.
The pyridine ring of this compound is aromatic, stable in nature, and can undergo electrophilic substitution reaction. Due to the strong electronegativity of the nitrogen atom on the pyridine ring, the electron cloud density distribution on the ring is uneven, and the electrophilic substitution reaction mainly occurs at the relatively high electron cloud density of the pyridine ring.
In addition, the interaction between the groups in the molecule affects each other. The conjugation of hydroxyl group and pyridine ring can change the electron cloud density of pyridine ring and affect its electrophilic substitution activity. Methylsulfonyl group also affects the electron cloud distribution of the molecule through induction effect, and then affects the reactivity and chemical properties.

2-% hydroxyl-6- (methylmercapto) pyridine is used in many fields. In the field of medicine, it is a key pharmaceutical intermediate and can be used to produce antibacterial and antiviral drugs through a series of reactions. For example, when developing new quinolone antibacterial drugs, 2-% hydroxyl-6- (methylmercapto) pyridine can modify the structure, improve the antibacterial activity and targeting, accurately act on bacteria, and reduce damage to normal human cells.
In the field of pesticides, it can synthesize high-efficiency and low-toxicity pesticides. With this compound, special structure pesticide molecules are constructed, which are highly lethal to crop pests and easily degradable in the environment, reduce soil and water pollution, and ensure ecological environment and agricultural product safety.
In the field of materials science, 2-% hydroxyl-6- (methylmercapto) pyridine can participate in the preparation of functional materials. For example, the preparation of materials with special optical and electrical properties can be used in organic Light Emitting Diodes (OLEDs), sensors and other devices. In OLEDs, it can optimize the performance of the light-emitting layer, improve the luminous efficiency and stability of the device, and make the display picture clearer and brighter.
In the field of chemical synthesis, it is an important building block for organic synthesis. With its active chemical properties, it can react with a variety of reagents to construct complex organic molecular structures, providing organic synthesis chemists with a wealth of choices, helping to create novel compounds and promoting the development of chemical science.

What is the market price of dihydroxyhexa (methacryloxy) benzene today?
Looking at the price of various things in the market, it often varies according to its quality, its production, and its supply and demand conditions. This dihydroxyhexa (methacryloxy) benzene, if it is of high quality and refined, will have a high price; if it is of average quality, the price may be moderate.
Furthermore, if there is a large number of people who need it, but there are few people who supply it, the price will be high; if the supply exceeds the demand, the price will drop. However, if you want to know the market price, you should visit Jia people in various cities, observe the records of transactions, and refer to the prices of the same industry. The market is fickle, or the price is high today, and the price is low tomorrow. It is unknown.
I have not obtained the actual price. If you want to know, you can go to the chemical market, consult the merchants, or visit the network of chemical transactions, and you will get a more accurate price. In this way, you will not be able to ask for it in trade, but you can almost get a good price.