2-Bromo-6-formylpyridine

2-Bromo-6-formylpyridine is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of organic synthesis.
One of them can be used to create many bioactive compounds. Because of its molecular structure, both bromine atoms and formyl groups have high reactivity. Bromine atoms can participate in nucleophilic substitution reactions, allowing chemists to introduce various functional groups, such as reacting with nucleophiles containing nitrogen, oxygen, sulfur, etc., to form new carbon-heteroatomic bonds, thereby constructing compounds with diverse structures. This is of great significance in the field of medicinal chemistry, and can help to develop new drug molecules, providing the possibility to overcome difficult diseases.
Second, it is also useful in materials science. It can be integrated into the structure of polymer materials through specific chemical reactions. Formalyl groups can participate in polycondensation reactions, etc., so that the resulting materials have unique physical and chemical properties, such as improving the solubility, thermal stability and optical properties of the materials. In this way, 2-bromo-6-formylpyridine can play an important role in the preparation of high-performance polymer materials, optoelectronic materials, etc., and promote the progress of materials science.
Third, it is an important starting material in the construction of heterocyclic compounds. Pyridine ring is the core structural unit of many bioactive molecules and functional materials. Combined with its bromine and formyl activities, it can ingeniously construct more complex heterocyclic systems through multi-step reactions. This is of great value in enriching the structural types of organic compounds and expanding the boundaries of organic synthetic chemistry.

The synthesis method of 2-bromo-6-formylpyridine is described in detail by you.
One method can be started from 2-bromo-pyridine. First, 2-bromo-pyridine is treated with an appropriate base, such as n-butyllithium (n-BuLi), at a low temperature such as -78 ° C. Then an appropriate amount of N, N-dimethylformamide (DMF) is added, which can be used as a source of formyl groups. After the reaction is completed, 2-bromo-6-formylpyridine can be obtained through a hydrolysis step. In this process, the activity of n-butyl lithium is very high, and the operation needs to be in an anhydrous and oxygen-free environment to prevent adverse reactions with water, oxygen, etc. And low temperature conditions are crucial to control the selectivity of the reaction, which can avoid lithium from occurring in other positions.
The second method uses 6-methyl-2-bromopyridine as the starting material. First use an appropriate oxidizing agent, such as a mixed system of manganese dioxide (MnO _ 2) and sulfuric acid (H _ 2O _ SO _), to oxidize the methyl group to an aldehyde group. However, the amount of oxidizing agent and the reaction conditions need to be precisely adjusted, because excessive oxidation may cause the aldehyde group to further oxidize to a carboxyl group. When the reaction is in progress, the reaction progress can be monitored by means of thin-layer chromatography (TLC), etc. When the raw material point disappears or the expected conversion rate is reached, the reaction is terminated. After subsequent separation and purification steps, such as column chromatography, with suitable eluents, pure 2-bromo-6-formylpyridine can be obtained.
There are also 2,6-dibromo-pyridine as a starting material. The 2,6-dibromo-pyridine is reacted with carbon monoxide (CO) and methanol (CH-OH) under certain pressure and temperature conditions in the presence of a palladium catalyst such as tetrakis (triphenylphosphine) palladium (Pd (PPh)). After carbonylation and hydrolysis, one of the bromine atoms can be converted into a formyl group to produce 2-bromo-6-formylpyridine. In the reaction, the activity of palladium catalyst affects the reaction rate and yield, and the pressure and temperature need to be carefully adjusted to achieve the best reaction effect.

2-Bromo-6-formylpyridine is an important compound in organic chemistry. Its physical properties are quite impressive.
In terms of its appearance, at room temperature, it is mostly in a solid state. This is due to the presence of specific forces between molecules, resulting in stable aggregation morphology. Looking at its color, it is usually white to light yellow powder or crystal. This color state characteristic may be related to the distribution and transition of electron clouds in the molecular structure.
Its melting point is also a key physical property. After many experiments, this compound will melt from solid to liquid at a certain temperature range. The exact value of this melting point range is of great significance for the purification, identification and subsequent reaction operations of the substance. The accurate determination of the melting point can help to distinguish the purity of the compound. If impurities are mixed, the melting point often changes.
As for solubility, 2-bromo-6-formylpyridine exhibits different solubility properties in common organic solvents. In some polar organic solvents, such as dichloromethane, N, N-dimethylformamide, it has good solubility. This is because the molecular structure contains both polar aldehyde groups and pyridine rings. It can interact with polar organic solvents through intermolecular forces, such as hydrogen bonds, van der Waals forces, etc., to achieve dissolution. However, in water, its solubility is relatively limited, because although the polarity of water is strong, the matching degree with the intermolecular forces of the compound is not as good as that of a specific organic solvent, so the amount of dissolution is small.
In addition, its density is also a physical property that cannot be ignored. Although the specific value needs to be determined by precise experiments, knowing its density is useful for many chemical operations, such as the accurate calculation of the amount of material in the reaction system and the process of phase separation.
In conclusion, the physical properties of 2-bromo-6-formylpyridine are fundamental and critical elements in many fields such as organic synthesis and drug development. Only by in-depth understanding can we better control this compound and carry out various chemical research and practical applications.

2-Bromo-6-formylpyridine is one of the organic compounds with unique chemical properties. In its structure, the bromine atom and formyl group occupy a specific position in the pyridine ring, and this structure endows it with diverse reactivity.
Let's talk about its nucleophilic substitution reaction first. Bromine atoms have good activity and can be attacked by many nucleophilic reagents. In case of hydroxyl negative ions, substitution can occur, and bromine is replaced by hydroxyl groups to obtain hydroxyl-containing pyridine derivatives. This reaction is easier to carry out in an alkaline environment. Because alkalinity can enhance the nucleophilicity of nucleophilic reagents, it is easier to interact with bromine atoms and promote the reaction to the right.
In addition, formyl groups are also active and reactive. It can condensate with compounds containing active hydrogen, such as alcohols. Under acidic catalysis, the carbonyl group of formyl groups condenses with the hydroxyl group of alcohols to form hemiacetal or acetal structures. This reaction is often used in organic synthesis to protect aldehyde groups or to construct complex cyclic structures.
And because of its aromatic pyridine ring and special electron cloud distribution, 2-bromo-6-formylpyridine can participate in aromatic electrophilic substitution reactions. However, due to the fact that both bromine and formyl groups are electron-withdrawing groups, the electron cloud density of the pyridine ring will be reduced, and the electrophilic substitution reactivity is lower than that of the benzene ring, and the reaction check point is mostly in the relatively high electron cloud density of the pyridine ring.
In addition, the formyl group in 2-bromo-6-formylpyridine can be reduced. With an appropriate reducing agent, such as sodium borohydride, the formyl group can be reduced to hydroxymethyl, and the corresponding alcohol derivatives can be obtained. This reduction reaction has mild conditions and convenient operation, and is often used in the preparation of alcohols in organic synthesis. The chemical properties of 2-bromo-6-formylpyridine are rich and diverse, and it can be used as an important intermediate in the field of organic synthesis. Through different reaction paths, various organic compounds with complex structures can be constructed.

I look at your question, but I am inquiring about the market price of 2-bromo-6-formylpyridine. However, this price often changes over time and is subject to various factors, such as quality, supply and demand, purchase quantity, purchase location and purchase time.
In the chemical raw material market, the price of this chemical may vary according to the quality level. The preferred price may be slightly higher, while the price suitable for conventional use may be slightly lower. If the purchase volume is very large, the supplier often offers discounts to encourage bulk purchases.
In addition, the purchase location also has an impact. In the chemical market in different regions, or due to different logistics costs, local supply and demand trends, the price varies. And at any time, the price fluctuates as supply and demand change. If there is a peak demand season or a shortage of raw materials, the price often rises; conversely, if the market oversupply, the price may drop.
To know the exact price, consult chemical raw material suppliers, distributors, or check the chemical product trading platform in detail to get real-time and accurate prices.