2-bromo-6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridine

2-Bromo-6- (4-isopropyl-4H-1,2,4-triazol-3-yl) pyridine, an organic compound. It is widely used in the field of medicinal chemistry and is often used as a key intermediate to synthesize many drugs. Drug developers can build molecules with specific biological activities, such as antibacterial, antiviral or anti-tumor drugs, with its unique chemical structure. In the field of pesticides, it may help to create new pesticides that show good control effects against specific pests or pathogens, ensure the healthy growth of crops, and improve yield and quality. In the field of materials science, this compound can be used as a basis for the preparation of materials with special properties, such as optoelectronic materials. Due to the specific structure, the material is endowed with unique optical or electrical properties, which may have extraordinary performance in optoelectronic devices. This compound plays an important role in many important fields due to its structural properties, bringing many possibilities for scientific research and industrial production.

The common methods for synthesizing 2-bromo-6- (4-isopropyl-4H-1,2,4-triazole-3-yl) pyridine are as follows.
One is to use a compound containing a pyridine structure as the starting material, and the second position of the pyridine is introduced into the bromine atom through a bromination reaction. In this bromination step, a suitable brominating reagent, such as liquid bromine, can be used in combination with a suitable catalyst to promote the precise substitution of the bromine atom in the target position under suitable reaction temperature and time conditions.
Then, the brominated pyridine derivative is coupled with a reagent containing 4-isopropyl-4H-1,2,4-triazole-3-yl. This coupling reaction requires careful selection of reaction conditions, such as suitable bases, catalysts and organic solvents. Commonly used bases can help activate the reactants, and suitable catalysts, such as palladium-based catalysts, can efficiently promote the reaction process. The choice of organic solvents is also critical, considering its solubility to the reactants and catalysts and the stability of the reaction system.
Another synthesis idea is to first construct an intermediate containing 4-isopropyl-4H-1,2,4-triazole-3-yl, and then combine this intermediate with a bromopyridine-containing structure. In this process, when constructing a triazole intermediate, precise control of reaction conditions is required to ensure the correctness and purity of its structure.
In the binding step, bonding reactions commonly used in organic synthesis, such as nucleophilic substitution reactions, can be used. According to the activity of the reactants and the reaction check point, the temperature, time and molar ratio of the reactants were adjusted to promote the smooth progress of the reaction to obtain high-purity 2-bromo-6- (4-isopropyl-4H-1,2,4-triazole-3-yl) pyridine products.

2 - bromo - 6 - (4 - isopropyl - 4H - 1, 2, 4 - triazol - 3 - yl) pyridine, which is an organic compound. To know its physical properties, when looking at its appearance, melting point, solubility, density, refractive index and other characteristics.
Looking at its appearance, under room temperature and pressure, it is either a solid or a liquid, but mostly solids, the cover is caused by its intermolecular force. Among organic compounds, those with complex structures and relatively large molecular masses are often in a solid state. This compound contains bromine atoms, pyridine rings and triazole groups, and its structure is complex and the intermolecular force is strong, so the possibility of solid state is quite large.
The melting and boiling point is related to the strength of the intermolecular force. This compound contains bromine atoms, and the relative weight of bromine atoms is large, which can enhance the intermolecular dispersion force; and the nitrogen atoms in the pyridine ring and triazole group can participate in the formation of hydrogen bonds, further strengthening the intermolecular force. Therefore, its melting and boiling point may be higher, and more energy is required to overcome the intermolecular force.
Solubility depends on the polarity of the molecule and the polarity of the solvent. "Similar miscibility" is a general rule. Polar compounds are easily soluble in polar solvents, and non-polar compounds are easily soluble in non-polar solvents. This compound contains polar groups, such as the pyridine ring and the nitrogen atom in the triazole group have solitary pairs of electrons, which can cause the molecule to have a certain polarity. Therefore, it may have a certain solubility in polar solvents, such as water, alcohols, and ketones. However, due to the hydrophobic isopropyl group, its solubility in water may be limited, and its solubility in organic solvents such as ethanol and acetone may be better.
The density is related to the relative molecular weight and the degree of molecular packing. The relative molecular weight of this compound is large, and the molecular structure is compact, and the intermolecular arrangement or tight, so the density may be larger, greater than that of common organic solvents, or similar to that of water. However, the exact value needs to be determined experimentally. < Br >
The refractive index is also an important physical property, reflecting the ability of a substance to refract light. It is related to the molecular structure and the distribution of electron clouds. This compound contains conjugated systems, such as pyridine rings and triazole groups. The conjugated system can affect the distribution of electron clouds, which in turn affects the speed of light propagation, giving its refractive index a unique value. However, the specific value also needs to be accurately determined by experiments.
The physical properties of this compound are significantly affected by its molecular structure, but the exact value depends on experimental determination to obtain accurate results.

2-Bromo-6- (4-isopropyl-4H-1,2,4-triazol-3-yl) pyridine is an organic compound with unique chemical properties.
In this compound, the presence of bromine atoms gives it specific reactivity. As a good leaving group, bromine atoms are easily replaced by nucleophiles in nucleophilic substitution reactions, thereby forming new carbon-heteroatom bonds. For example, when encountering nucleophiles containing nitrogen and oxygen, nucleophilic substitution can occur, and different functionalized products can be derived.
Pyridine ring is also a key structural part. The pyridine ring is aromatic and has a unique electron cloud distribution, which can participate in various electron transfer and ring substitution reactions. Its nitrogen atom has a lone pair of electrons, which can be used as an electron donor to participate in coordination chemistry and form complexes with metal ions, which has potential applications in catalysis and materials science.
4-isopropyl-4H-1,2,4-triazol-3-yl groups also affect the properties of compounds. The triazole ring has electron-rich properties and is connected to the pyridine ring. The molecular electron cloud distribution is changed due to conjugation effect, which affects the overall stability and reactivity. As an electron supplier group, isopropyl can increase the electron cloud density of the triazole ring, which further affects the reactivity and physical properties of the compound, such as its solubility, melting point, boiling point and other physical properties.
This compound can be used as a key intermediate in the field of organic synthesis to construct more complex organic molecules, and has potential application value in many fields such as medicinal chemistry and materials science.

I don't know the price of 2-bromo-6- (4-isopropyl-4H-1,2,4-triazol-3-yl) pyridine in the market. This is a fine chemical substance, and its price often varies due to many factors.
First, the price of raw materials is the main factor. If the raw materials required for the synthesis of this compound are easy to obtain and affordable, the price of the finished product may be relatively low; if the raw materials are rare and difficult to prepare, the price must be high.
Second, the complexity of the preparation process also affects the price. If there are many synthesis steps and special reaction conditions are required, such as high temperature, high pressure, specific catalysts, etc., the production cost will increase and the price will be high; if the process is simple, the cost is controllable, and the price is close to the people.
Third, the market supply and demand relationship is the key. If the product has a large demand in the fields of medicine, pesticides, etc., but the supply is limited, the price will rise; if the market demand is low and the supply is sufficient, merchants may reduce the price and promote it.
Fourth, the purity of the product is related to the price. High purity is used in high-end scientific research, pharmaceutical manufacturing, etc., which requires strict impurities, is difficult to prepare, and the price is high; low purity is used in general industrial use, and the
Prices fluctuate over time due to the vagaries of the market. Or due to the advent of new preparation technologies, the cost decreases and the price falls; or due to the shortage of raw materials, the price rises. To know the exact price, consult chemical product suppliers, trading platforms, or check relevant market survey reports to get a close price.