2 Bromo 5 Pyridinecarboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

2-bromo-5-Pyridinecarboxylic acid

    Specifications

    HS Code

    436383

    Name 2-bromo-5-Pyridinecarboxylic acid
    Molecular Formula C6H4BrNO2
    Molecular Weight 202.005 g/mol
    Appearance Solid
    Color White to off - white
    Boiling Point Decomposes
    Melting Point 224 - 226 °C
    Solubility In Water Slightly soluble
    Pka ~3.5
    Density 1.802 g/cm³ (estimated)

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    General Information
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    Frequently Asked Questions

    As a leading 2-bromo-5-Pyridinecarboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemistry of 2-bromo-5-Pyridinecarboxylic acid?
    2-Bromo-5-pyridinecarboxylic acid, or 2-bromo-5-pyridinecarboxylic acid, is a family of organic compounds. Its physical and chemical properties are unique, and it has a wide range of uses in the field of organic synthesis.
    Let's talk about its physical properties first. This compound is mostly in a solid state at room temperature, and its color may be white to light yellow powder. Because the molecule contains both polar carboxyl groups (-COOH), pyridine rings and bromine atoms, its solubility in water is limited, but in some polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), the solubility is acceptable.
    As for chemical properties, the presence of carboxyl groups makes the compound acidic. Carboxyl groups can neutralize with bases to form corresponding carboxylate salts. For example, when reacted with sodium hydroxide (NaOH), 2-bromo-5-pyridyl formate sodium salt and water can be formed. This reaction is typical of acid-base neutralization and follows the law of general acid-base reactions.
    Furthermore, the activity of bromine atoms is also one of its important chemical properties. Bromine atoms can participate in a variety of substitution reactions. In nucleophilic substitution reactions, nucleophiles such as alcohols and amines can replace bromine atoms, thereby forming new carbon-oxygen or carbon-nitrogen bonds. This property makes 2-bromo-5-pyridinecarboxylic acid a key intermediate for the synthesis of complex organic molecules.
    The conjugated structure of the pyridine ring endows the compound with certain stability and electronic properties. The nitrogen atom on the pyridine ring can act as an electron receptor to participate in the electron transfer process, which affects the reactivity and selectivity of the molecule. Under specific conditions, the pyridine ring can also undergo electrophilic substitution reactions, introducing other functional groups on the pyridine ring to enrich the structure and function of the molecule. Due to its unique physical and chemical properties, 2-bromo-5-pyridinecarboxylic acid has important application value in many fields such as medicinal chemistry and materials science, providing rich possibilities for the study of organic synthetic chemistry.
    What are the main uses of 2-bromo-5-Pyridinecarboxylic acid?
    2-Bromo-5-pyridinecarboxylic acid, which has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many drugs. The structure of the pyridine ring is crucial in many drug molecules. Bromine atoms and carboxyl groups can be modified by various chemical reactions to construct compounds with specific biological activities. For example, when developing antibacterial and anti-inflammatory drugs, this is the starting material. By introducing different substituents, drugs with ideal pharmacological properties can be obtained.
    In the field of materials science, 2-bromo-5-pyridinecarboxylic acid also has important uses. It can be used to prepare functional materials whose carboxyl groups can coordinate with metal ions to form metal-organic framework materials (MOFs). Such materials exhibit excellent properties in gas adsorption and separation, catalysis, etc. Due to their unique pore structure and large specific surface area, they have high selective adsorption capacity for specific gas molecules, which is of great significance in the process of industrial gas purification and separation.
    Furthermore, in the field of organic synthesis chemistry, 2-bromo-5-pyridinecarboxylic acid is an important building block for the synthesis of complex organic compounds. Bromine atoms have high activity, can undergo nucleophilic substitution, coupling and other reactions, and combine with other organic reagents to form diverse carbon-carbon bonds and carbon-heteroatomic bonds, thereby enriching the structural types of organic compounds and providing organic synthesis chemists with more possibilities for creating novel compounds. In short, 2-bromo-5-pyridinecarboxylic acid plays an indispensable role in many scientific fields, promoting the development and innovation of technologies and products in various fields.
    What is the synthesis method of 2-bromo-5-Pyridinecarboxylic acid?
    To prepare 2-bromo-5-pyridinecarboxylic acid, the following ancient method can be used.
    Take 5-pyridinecarboxylic acid as the base material and place it in a suitable reaction vessel. Glacial acetic acid is used as the solvent, which can fully disperse the reactants and facilitate the reaction. Slowly add an appropriate amount of brominating agent, such as bromine or N-bromosuccinimide (NBS). If bromine is used, it must be handled with caution because of its strong oxidizing and corrosive properties. When adding bromine, it should be stirred at low temperature to prevent the reaction from being too violent.
    The reaction needs to be assisted by a catalyst, and benzoyl peroxide can be selected. The catalyst can reduce the activation energy of the reaction and speed up the reaction rate. Maintain the reaction system at an appropriate temperature, generally about 60-80 ° C. This temperature range can not only ensure the reaction rate, but also avoid excessive side reactions. During the reaction, close observation of the system changes, and it can be seen that the color or state of the solution has changed.
    After the reaction is completed, the reaction solution is poured into ice water, and the precipitation is precipitated. This precipitation contains the target product 2-bromo-5-pyridinecarboxylic acid. Then the precipitation is separated by filtration and washed with an appropriate amount of cold water to remove impurities. After drying, the crude product can be obtained. < Br >
    To obtain pure 2-bromo-5-pyridinecarboxylic acid, the crude product can be recrystallized. Select a suitable solvent, such as ethanol-water mixed solvent, heat to dissolve the crude product, and filter it hot to remove insoluble impurities. The filtrate is cooled, that is, pure crystals are precipitated, filtered again, dried, and finally high-purity 2-bromo-5-pyridinecarboxylic acid is obtained.
    What is the market price of 2-bromo-5-Pyridinecarboxylic acid?
    2-Bromo-5-pyridinecarboxylic acid, the price of this product in the market is difficult to determine. The price of this product often changes due to many reasons, such as the trend of supply and demand, the method of preparation, the difference in quality, and even the rise and fall of market conditions.
    Looking at the market conditions of the past, if the ordinary quality is considered, in the market of chemical raw materials, the price varies with the quantity. A small amount of purchase, or the price is as high as tens of yuan per gram, because the merchant considers the cost of operation and logistics, and the cost apportionment is also large if the quantity is small, so the price is high.
    However, if the bulk purchase, the price per kilogram may be reduced to several thousand yuan. Due to the large quantity, the production scale can be expanded, the cost can be reduced, and the merchant is also willing to promote the transaction at a preferential price to seek long-term benefits.
    If the quality is extraordinary, specially refined, and suitable for high-end scientific research or medical preparation, the price is more unusual and comparable, or several times or even dozens of times that of ordinary products, and the price per gram can reach more than 100 yuan, or even higher, depending on its purity, impurity control and other indicators.
    And the difference in region also affects its price. Prosperous cities, convenient transportation, smooth supply and demand, or the price is relatively cheap; while remote places, difficult logistics, cost superposition, or slightly higher price. Therefore, if you want to know the exact price, you should carefully observe the market conditions and consult the merchants before you can obtain a more accurate number.
    What are the precautions for 2-bromo-5-Pyridinecarboxylic acid during storage and transportation?
    2-Bromo-5-pyridinecarboxylic acid is an organic compound. During storage and transportation, many matters need to be paid attention to to to ensure its quality and safety.
    When storing, the first environment is dry. Because of its certain hygroscopicity, if the environment is humid, it is easy to cause moisture absorption and deterioration, so it should be stored in a dry and ventilated place, away from water sources and moisture. And the humidity of the warehouse should be controlled between 40% and 60% relative humidity.
    Temperature is also very important, and it should be stored in a cool place to avoid high temperature. This compound may decompose or cause chemical reactions when heated, threatening safety. In general, the storage temperature should be maintained at 2-8 ° C, especially during the high temperature in summer, it is necessary to pay more attention to the cooling of the warehouse.
    Furthermore, it is necessary to prevent it from coming into contact with oxidants, alkalis and other substances. 2-Bromo-5-pyridinecarboxylic acid can oxidize with some oxidants, and it will also react chemically with alkalis, affecting its purity and stability. Be sure to store separately and not mix.
    During transportation, the packaging must be stable. Suitable packaging materials should be used to ensure that there is no leakage during handling and turbulence. Commonly used packaging includes glass bottles plus wooden box lining, or plastic drums to ensure good sealing.
    Transportation tools should also be kept clean and dry, free of residual impurities and moisture. At the same time, during transportation, avoid sun and rain, pay attention to control the temperature inside the car, and prevent the temperature from being too high.
    In addition, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards. Operators should be familiar with its characteristics and emergency treatment methods. In the event of an accident such as leakage, effective measures can be taken quickly to ensure the safety of personnel and the environment from pollution.