2-BROMO-5-PHENYLPYRIDINE

2-Bromo-5-phenylpyridine is also an organic compound. It has a wide range of uses and is particularly important in the field of organic synthesis.
First, it can be used as a pharmaceutical intermediate. When covering the research and development of medicine, it is necessary to build a complex molecular structure. The chemical structure of 2-bromo-5-phenylpyridine can participate in a variety of chemical reactions, and can be converted into compounds with specific pharmacological activities through clever design and synthesis steps. For example, when developing drugs for specific diseases, the substance can react with other reagents, or key pharmacoactive groups can be constructed, providing important starting materials for the creation of new drugs.
Second, it is also used in the field of materials science. With the development of science and technology, the demand for special performance materials is increasing. 2-Bromo-5-phenylpyridine can participate in the synthesis of polymers or functional materials. Due to its structural properties, it may endow materials with unique electrical and optical properties. For example, when preparing organic optoelectronic materials, introducing them into molecular structures may improve the luminous efficiency and charge transport properties of materials, which are expected to be used in the manufacture of high-performance Light Emitting Diodes, solar cells and other optoelectronic devices.
Third, in organometallic catalytic reactions, 2-bromo-5-phenylpyridine can be used as a ligand. Combined with metal catalysts, the activity and selectivity of the catalyst can be adjusted. In various coupling reactions, such as Suzuki coupling, Heck coupling, etc., it can promote the smooth progress of the reaction, efficiently construct carbon-carbon bonds, carbon-heteroatomic bonds, etc., providing a powerful tool for the synthesis of complex organic molecules, and playing an important role in the synthesis of fine chemical products.

2-Bromo-5-phenylpyridine is an important compound in the field of organic chemistry. It has many unique physical properties, which are listed below.
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions. This color state characteristic can be used as an important basis for preliminary identification and distinction of this compound.
When it comes to melting point, the melting point of 2-bromo-5-phenylpyridine is in a specific range, about [specific melting point value] degrees Celsius. The exact determination of melting point is of great significance in the determination of purity. If the sample purity is high, the melting point value is stable and similar to the theoretical value; if it contains impurities, the melting point is often reduced and the melting range is widened.
In terms of boiling point, under atmospheric pressure conditions, its boiling point is about [specific boiling point value] degrees Celsius. The boiling point information plays a significant role in the separation and purification of compounds. According to the difference in boiling points of different compounds, separation can be achieved by distillation and other means.
In terms of solubility, 2-bromo-5-phenylpyridine exhibits different solubility characteristics in organic solvents. Easily soluble in common organic solvents, such as dichloromethane, chloroform, toluene, etc. This solubility property is crucial in the selection of solvents for organic synthesis reactions. Suitable solvents can promote the full progress of the reaction and improve the reaction efficiency and yield. In water, its solubility is poor, which also affects the selection of related chemical reaction systems and post-treatment methods of the compound.
In addition, the density of 2-bromo-5-phenylpyridine is [specific density value] g/cm3. As one of the physical constants, density provides important basic data for compound quality and volume conversion, related chemical design and process optimization.
In summary, the physical properties of 2-bromo-5-phenylpyridine, such as color state, melting point, boiling point, solubility, density, etc., play a key role in its application in many fields such as organic synthesis, drug development, and materials science. Researchers can rationally design and optimize related experiments and production processes according to their physical properties.

The synthesis method of 2-bromo-5-phenylpyridine has been known for a long time. The methods are diverse and each has its own advantages. The details are as follows.
First, pyridine is used as a group, and phenyl is introduced first. Pyridine and phenyl halide can be nucleophilic substitution in the presence of suitable bases and catalysts. For example, potassium carbonate is used as a base, and a palladium catalyst is heated and stirred in an organic solvent to promote the combination of the two to obtain 5-phenylpyridine. Then, 5-phenylpyridine is brominated. Bromine can be selected as bromine source or N-bromosuccinimide (NBS), and bromine atoms can be introduced into the 2-position of the pyridine ring under the action of suitable solvents and initiators. For example, carbon tetrachloride is used as solvent and benzoyl peroxide is used as initiator. Heating the reaction, the target product 2-bromo-5-phenylpyridine can be obtained.
Second, benzene is used as the starting material. First, a series of reactions are carried out to construct a pyridine ring on the phenyl ring. For example, through benzaldehyde and acetonitrile compounds, under alkali catalysis, through condensation, cyclization and other steps, 5-phenylpyridine derivatives are generated. Then through the bromination step, as described above, bromine atoms are introduced into the 2-position of the pyridine ring by the NBS bromination method to obtain 2-bromo-5-phenylpyridine.
Third, the coupling reaction catalyzed by transition metals is first prepared. Pyridyl-containing halides and phenyl-containing boric acid or borate esters. Then, under the action of transition metal catalysts such as palladium catalysts, under basic conditions, Suzuki coupling reaction can be carried out to directly synthesize 2-bromo-5-phenylpyridine. This method has relatively mild conditions, good selectivity and considerable yield.
All synthesis methods have their own advantages and disadvantages. The purpose of synthesis can be achieved only by carefully choosing according to the actual needs, the availability of raw materials, the difficulty of reaction conditions, the purity of the product, and many other factors.

For 2-bromo-5-phenylpyridine, many matters should be paid attention to during storage and transportation. This compound has special properties and is related to safety and quality. It should not be ignored.
First of all, storage should be placed in a cool and dry place. If the environment is hot and humid, it is easy to cause it to deteriorate. This is because of the temperature and humidity, or the unprovoked occurrence of chemical reactions, which damages the structure of 2-bromo-5-phenylpyridine and loses its inherent characteristics. Second, the storage place must be kept away from fire and heat sources. Because of its flammability, it may be dangerous to fire and endanger the safety of the surrounding area. Third, it should be stored separately from oxidants, acids, alkalis and other substances. Due to its active chemical properties, it coexists with various chemicals, which is prone to chemical reactions, or causes explosions, harmful gases and other serious consequences.
As for transportation, the first heavy packaging. The packaging must be strong and well sealed to prevent leakage. If 2-bromo-5-phenylpyridine leaks during transportation, it will not only damage the material, but also pollute the environment and endanger human health. During transportation, care should also be taken to load and unload to avoid collisions and heavy pressure. This substance may break the package due to severe impact and excessive extrusion, causing danger. Furthermore, the transportation vehicle must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. If an accident occurs on the way, it can be responded to in time to reduce losses and hazards.
In short, 2-bromo-5-phenylpyridine has strict requirements on the environment, packaging, operation, etc. during storage and transportation. Following these requirements can ensure its safety and avoid life risks.

2-Bromo-5-phenylpyridine, this product is in the market, and its price is difficult to determine. Given the change in its price, it depends on many ends. First, the quantity of production is also. If the product is abundant, the market supply is abundant, and the price may be leveled; if the product is scarce, the demand exceeds the supply, and the price will rise. Second, the quality is also heavy. Those who are of high quality, the price will be high; those who are slightly inferior in quality, the price may be cheap. Furthermore, the method of making is also involved. Simple and efficient methods can reduce costs, and the price is also appropriate; complex and expensive methods, the cost will increase, and the price will rise accordingly. And there is a market need, which is also the key. At a certain time, in a certain domain, if there is a large number of people who need it, the price may rise; when the demand is small, the price also tends to fall. And among suppliers, the competition is different, which also makes the price different. Therefore, in order to know the exact price, we must consider all the circumstances in detail, and observe it carefully in the city, so that we can get a more accurate number. It is difficult to say a word to cover the geometry of the price.