2-Bromo-5-methyl-3-nitropyridine

2-Bromo-5-methyl-3-nitropyridine is also an organic compound. Its chemical properties are particularly important and are widely used in the field of organic synthesis.
In this compound, the presence of bromine atoms, methyl groups and nitro groups endows it with unique reactivity. Bromine atoms are active and can often participate in nucleophilic substitution reactions. The capped bromine atoms are quite electronegative, and the bond energy of the C-Br bond is suitable, making it easy for nucleophiles to attack the carbon atoms attached to them and replace the bromine atoms. For example, by interacting with nucleophiles such as alkoxides and amines, corresponding substitution products can be formed, which is crucial for the construction of new carbon-heteroatom bonds.
Although the methyl group is relatively stable, it can affect the electron cloud distribution and spatial structure of the molecule. Because the methyl group is the power supply group, the electron cloud density on the pyridine ring can increase, and the reactivity at other positions on the ring can be affected, especially in the electrophilic substitution reaction, the reaction check point can be biased.
Nitro is a strong electron-absorbing group, which greatly affects the electron cloud distribution of the pyridine ring, and the electron cloud density of the adjacent and para-position is significantly reduced. This property makes the carbon atoms of the ortho and para-nitro groups vulnerable to attack by nucleophiles. At the same time, the presence of nitro groups also enhances the polarity of molecules and affects their physical properties, such as solubility.
In addition, 2-bromo-5-methyl-3-nitropyridine has certain stability and aromaticity due to the conjugated structure of the pyridine ring. However, the substitution of bromine, methyl and nitro groups breaks the uniform distribution of their original electron clouds, endowing molecules with diverse reaction paths, providing many possibilities for organic synthesis chemists to create new compounds. The exploration and utilization of its chemical properties are of great significance in many fields such as medicinal chemistry and materials science.

2-Bromo-5-methyl-3-nitropyridine is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. Due to its unique structure, it can derive many bioactive compounds through various chemical reactions, paving the way for the creation of new drugs.
In the field of pesticide chemistry, it also plays an important role. It can be converted into pesticide ingredients with specific biological activities by chemical modification, or has insecticidal and bactericidal effects, which can help agricultural production protection.
In the field of materials science, this compound may participate in the synthesis of materials with specific functions. Due to its special chemical structure, it may endow materials with unique optical, electrical and other properties, providing new options for material research and development.
And because of its diverse reactivity, in the field of organic synthetic chemistry, chemists often use it to explore novel synthetic paths and methods, expand the boundaries of organic synthesis, and promote the progress of chemical science.
Most importantly, 2-bromo-5-methyl-3-nitropyridine has shown important uses in many fields. With the development of science and technology, its potential applications may be further explored.

To prepare 2-bromo-5-methyl-3-nitropyridine, the following method can be followed.
First, 5-methylpyridine is used as the starting material. The pyridine ring of 5-methylpyridine has a certain reactivity, and it can be nitrified first. In a suitable reaction vessel, 5-methylpyridine is mixed with a mixed acid (sulfuric acid and nitric acid in a certain proportion). Sulfuric acid can enhance the nitrification ability of nitric acid. This reaction needs to be carried out in a suitable temperature range, generally controlled at a low temperature, such as between 0-10 ° C. Nitro positive ions in nitric acid act as electrophilic reagents to attack specific positions on the 5-methylpyridine pyridine ring. Due to the fact that methyl is an o-para-site group, and the electron-absorbing of the pyridine ring nitrogen atom reduces the electron cloud density of the pyridine ring. Under the combined action, the nitro group mainly enters the methyl meta-site to form 3-nitro-5-methylpyridine.
After obtaining 3-nitro-5-methylpyridine, the bromination reaction is carried out. Brominating reagents such as N-bromosuccinimide (NBS) and benzoyl peroxide (BPO) are often used as initiators. In the reaction system, NBS produces bromine free radicals under the action of initiators. In 3-nitro-5-methylpyridine, because the electron cloud density of the pyridine ring is affected by nitro and methyl groups, the electron cloud density at a specific position is relatively high, and bromine radicals attack this position, and radical substitution reactions occur, and finally 2-bromo-5-methyl-3-nitropyridine is formed.
After the reaction is completed, the product needs to be separated and purified. Column chromatography can be used to select suitable silica gel as the stationary phase, and suitable organic solvents such as petroleum ether and ethyl acetate are mixed in a certain proportion as the mobile phase. Using the difference in the partition coefficients of the product and impurities in the stationary phase and the mobile phase, 2-bromo-5-methyl-3-nitropyridine can be separated to obtain a pure product.

The market price of 2-bromo-5-methyl-3-nitropyridine is difficult to determine. This is due to the changing price of the market, which often varies for many reasons.
First, the situation of supply and demand has a lot to do with it. If there are many people who want it, but the supply is small, the price will increase; if the supply exceeds the demand, the price may drop. If the goods are sold in the business, the demand is enthusiastic, and the price will rise; if there is a lot of supply but few people are interested, the price will drop.
Second, the cost of production is also a major factor. The price of raw materials, labor costs, and equipment consumption are all related to costs. The price of the raw materials is high, or the process is complicated, and the cost increases, so the price of the 2-bromo-5-methyl-3-nitropyridine produced will also be high.
Third, the competition of the market is not small. Compete with the industry, or to attract customers, or to expand the market, or to reduce its price, or to improve its quality. Where the competition is fierce, the price often changes accordingly.
Fourth, government decrees and regulations can also influence. The adjustment of taxes and changes in regulation can make prices different. Taxes increase, business costs increase, or change to prices, resulting in higher prices. < Br >
And the market price varies from time to place. Therefore, in order to know the exact price of 2-bromo-5-methyl-3-nitropyridine, it is necessary to visit the market of chemical raw materials in real time, or consult the franchisee to obtain a more accurate number.

2-Bromo-5-methyl-3-nitropyridine is an organic compound. When storing and transporting, the following matters must be paid attention to.
First storage conditions. Because of its certain chemical activity, it should be stored in a cool, dry and well-ventilated place. If placed in a high temperature or humid place, it may cause deterioration. The warehouse temperature should be controlled within a specific range to prevent its stability from being damaged due to excessive temperature. And keep away from fires and heat sources. Because the compound may be flammable, it may encounter open flames, hot topics or risk combustion and explosion.
Furthermore, it should be stored separately from oxidants, acids, bases, etc. This compound is chemically active, intermingling with these substances, or causing severe chemical reactions, resulting in danger. For example, when it encounters a strong oxidizing agent, or initiates an oxidation reaction, a large amount of heat is released, which can lead to combustion or explosion.
The choice of storage container is also crucial. Corrosion-resistant and well-sealed containers must be used to prevent leakage. If using glass bottles, the bottle mouth must be tightly sealed; if using metal containers, make sure that it does not react with the compound.
The transportation process also needs to be cautious. Transportation vehicles should be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment. During driving, it should be protected from exposure to the sun, rain, and high temperature. When handling, it should be handled lightly to avoid damage to packaging and containers. If the packaging is damaged, the compound leaks, or poses a hazard to the environment and personnel.
In addition, transportation and storage personnel need to be professionally trained to be familiar with the properties of the compound and emergency treatment methods. In the event of an accident such as a leak, effective measures should be taken quickly, such as evacuating people, cutting off fire sources, and properly handling leaks, to reduce hazards.