2-Bromo-5-iodo-3-methylpyridine

2-Bromo-5-iodine-3-methylpyridine is an important intermediate in organic synthesis. It has a wide range of uses and is particularly crucial in the field of medicinal chemistry.
In the field of pharmaceutical research and development, it is often the cornerstone of the creation of new drugs. Due to its unique structure, it can introduce various functional groups through various chemical reactions to build complex drug molecular structures. For example, in the development of anti-cancer drugs, using this as a starting material and carefully designed reaction routes can synthesize compounds with specific biological activities, which is expected to provide a new way to overcome cancer problems.
In the field of pesticide chemistry, it also plays an important role. Efficient, low-toxicity and environmentally friendly pesticides can be prepared by appropriate chemical modification. Such pesticides are very useful for precisely killing pests, protecting crop growth, and reducing the negative impact on the ecological environment.
In addition, in the field of materials science, 2-bromo-5-iodine-3-methylpyridine can also be used as a raw material for the synthesis of special functional materials. After specific polymerization reactions or molecular assembly processes, materials with unique optoelectronic properties or other special properties can be prepared, which can be used in cutting-edge technologies such as organic Light Emitting Diodes and sensors.
In conclusion, 2-bromo-5-iodine-3-methylpyridine, with its unique chemical structure, has shown broad application prospects in many fields such as medicine, pesticides and materials science, and has made outstanding contributions to promoting scientific and technological progress in various fields.

The synthesis method of 2-bromo-5-iodine-3-methylpyridine can be considered from the following paths.
First, pyridine is used as the initial substrate. First, pyridine is methylated, and suitable methylation reagents, such as iodomethane and bases (such as potassium carbonate), can be used to synergistically act on pyridine. In a suitable solvent (such as N, N-dimethylformamide), the reaction is heated to obtain 3-methylpyridine. Then, 3-methylpyridine is brominated. With a brominating reagent (e.g. N-bromosuccinimide), heating the reaction in a suitable solvent (e.g. carbon tetrachloride) in the presence of an initiator (e.g. benzoyl peroxide), bromine atoms can be introduced at the 2-position of the pyridine ring to obtain 2-bromo-3-methylpyridine. Finally, for 2-bromo-3-methylpyridine, an iodizing agent (such as potassium iodide) is used, assisted by an appropriate oxidizing agent (such as hydrogen peroxide), and reacted in a suitable solvent (such as methanol). The iodine atom can be introduced at the 5-position to obtain 2-bromo-5-iodine-3-methylpyridine.
Second, 3-methyl-2-aminopyridine can also be used as the starting material. First, the amino group is diazotized, and the diazonium salt is prepared by treating it with sodium nitrite and hydrochloric acid at low temperature. After that, the diazonium salt is treated with cuprous bromide and hydrobromic acid, and the 2-position amino group can be replaced by a bromine atom to obtain 2-bromo-3-methylpyridine. As in the previous method, 2-bromo-3-methylpyridine is iodized to obtain the target product 2-bromo-5-iodine-3-methylpyridine.
Alternatively, 3-methyl-5-nitropyridine is used as the starting material. Nitro groups are reduced to amino groups first, and 3-methyl-5-aminopyridine can be obtained by reducing systems such as iron powder and hydrochloric acid. Then, the amino group is diazotized, treated with sodium nitrite and sulfuric acid to form a diazonium salt. After that, the diazonium salt is treated with potassium iodide, and iodine atoms are introduced at the 5-position to obtain 3-methyl-5-iodopyridine. Finally, 3-methyl-5-iodopyridine is brominated, and a suitable brominating agent, such as liquid bromine, is reacted in a suitable solvent (such as dichloromethane) under the action of a catalyst (such as iron powder), and bromine atoms are introduced at the 2-position to obtain 2-bromo-5-iodopyridine.
This number method has its own advantages and disadvantages. In the actual synthesis, it is necessary to consider the availability of raw materials, the difficulty of controlling the reaction conditions, and the high or low yield.

2-Bromo-5-iodine-3-methylpyridine is also an organic compound. Its physical properties are much more impressive.
In terms of its appearance, under room temperature and pressure, or in a solid state, due to the force between molecules, its structure is relatively stable, and it is not easy to exist in a liquid or gaseous state. The color of this compound, or white to light yellow, is related to the absorption and reflection characteristics of the molecular structure.
As for the melting point, due to the existence of specific interactions between molecules, such as van der Waals forces, hydrogen bonds, etc., the melting point is within a certain range. However, the exact value will be affected by the degree of regularity of molecular arrangement and impurities. Generally speaking, the melting point of such pyridine derivatives containing halogen atoms and methyl groups may be between tens of degrees Celsius and hundreds of degrees Celsius.
The boiling point is also an important physical property. The strength of the intermolecular force determines the energy required for its gasification. The intermolecular force of 2-bromo-5-iodine-3-methyl pyridine is more complex, the dipole-dipole interaction caused by the electronegativity difference of the halogen atom, and the weak interaction participated by the methyl group. Therefore, its boiling point is higher, and more energy is required to overcome the intermolecular binding and make it change from liquid to gaseous state. < Br >
In terms of solubility, the compound may have a certain solubility in organic solvents, such as ethanol, ether, etc. Due to its molecular structure, there are both nitrogen-containing pyridine rings with a certain polarity, halogen atoms and methyl groups, and the whole presents certain hydrophobicity and lipophilicity. In water, its hydrophobic part accounts for a large proportion, and its solubility may be low.
Density is also one of the physical properties, and its value is related to the molecular weight and the degree of molecular accumulation. This compound contains elements with relatively large atomic mass such as bromine and iodine, and the molecular weight is heavier, and the intermolecular accumulation may be relatively close, so the density may be greater than that of common organic solvents.
In summary, the physical properties of 2-bromo-5-iodine-3-methylpyridine, such as appearance, melting point, boiling point, solubility, density, etc., are determined by its molecular structure, and are of great significance for the research and application of organic synthesis, medicinal chemistry, and other fields.

2-Bromo-5-iodine-3-methylpyridine is an organic compound with many unique chemical properties.
First, the substitution reaction of halogenated pyridine is an important property. In this compound, both bromine and iodine are active halogen atoms, which can participate in nucleophilic substitution reactions. For example, in the case of nucleophilic reagents, halogen atoms can be replaced by nucleophilic groups. Take alkoxides as an example. The oxygen atoms in alkoxides are nucleophilic and can attack the carbon atoms connected to halogen atoms in the pyridine ring. The halogen atoms leave to form corresponding substitution products. This reaction mechanism is that the nucleophilic reagent provides an electron pair, which bonds with the carbon atom, and the halogen atom leaves with a pair of electrons. < Br >
Second, the electron cloud distribution on the ring varies depending on the substituent group. Methyl group as the donator group can increase the electron cloud density of the pyridine ring, especially in the ortho and para-site effects. Bromine and iodine are electron-withdrawing groups, which will reduce the electron cloud density on the ring. Such electronic effects cause changes in the reactivity and selectivity of the pyridine ring. In the electrophilic substitution reaction, the choice of the reaction check point is influenced by the electron cloud density distribution. The donator group increases the density of the ortho and para-site electron clouds, and the electrophilic reagent is more likely to attack these positions; the electron-withdrawing group makes the meso-site relative to the electron cloud density higher, and the electrophilic substitution may tend to be meso-site.
Third, the alkalinity of The nitrogen atom of pyridine has a pair of unshared electron pairs, which has the ability to accept protons and is alkaline. However, due to the influence of substituents such as bromine, iodine and methyl, its alkalinity is different from that of pyridine itself. Electron-absorbing groups can reduce the electron cloud density of nitrogen atoms and weaken the basicity; while electron-donating groups, on the other hand, enhance the basicity.
Fourth, the compound can also participate in metal catalytic coupling reactions. In the presence of suitable metal catalysts and ligands, bromine and iodine atoms can be coupled with other organometallic reagents to form carbon-carbon bonds or carbon-heteroatom bonds, which are used in the preparation of complex compounds in the field of organic synthesis.

There are currently 2-bromo-5-iodine-3-methylpyridine, which is in the market price range and is difficult to determine with certainty. Due to many factors, its price is involved.
First, the price of raw materials is the key. If the price of bromide, iodide and methyl-containing pyridine raw materials required for the synthesis of this compound is high and fluctuates greatly, the price of the finished product will also be affected by it. If the price of raw materials is stable, the price of 2-bromo-5-iodine-3-methylpyridine may be stable and low.
Second, the preparation method is also affected. The complex and high-cost preparation process requires more equipment, reagents and manpower, which all increase costs and lead to higher prices. If there is a simple and efficient new method to reduce the preparation cost, the price may be close to the people.
Third, the market supply and demand trend cannot be ignored. If many industries, such as medicine, pesticide research and development, have strong demand for this product, but limited supply, the price will rise. On the contrary, if the demand is weak and the supply is sufficient, the price will easily drop.
Fourth, there are differences between manufacturers and regions. Different manufacturers have different costs and different pricing due to different technologies, scales, and management levels. And different regions have different prices due to different taxes, transportation costs, etc.
In summary, the market price of 2-bromo-5-iodine-3-methylpyridine fluctuates widely due to factors such as raw materials, preparation, supply and demand, manufacturers and regions, and it is difficult to explain the exact price range.