2-Bromo-5-hydroxypyridine

2-Bromo-5-hydroxypyridine is also an organic compound. It has unique physical properties and is very important in the field of chemistry.
In terms of its appearance, under room temperature and pressure, it often takes the shape of white to light yellow crystalline powder. This color state is easy to distinguish for the eye. It can be used as a basis for preliminary judgment when experimenting with and identifying substances.
As for the melting point, it is about 157-161 ° C. The melting point is an inherent property of a substance, just like a human fingerprint. A specific compound has a specific melting point range. With this property, the experimenter can verify the purity of the substance by accurately measuring the melting point. If the measured melting point is consistent with the known range, and the melting range is very narrow, it is highly likely that the purity of the substance is high; conversely, if the melting range is wide and the melting point deviates from the established range, the purity is questionable, or there are impurities mixed in it.
Solubility is also an important physical property. 2-Bromo-5-hydroxypyridine is slightly soluble in water, but it can be soluble in organic solvents such as dichloromethane and ethanol. This difference in solubility is due to the difference in its molecular structure and the interaction between water molecules and organic solvent molecules. Its solubility in organic solvents is of great significance in organic synthesis, and it is often used as a consideration in the selection of reaction solvents. It is also conducive to the separation and purification of the substance from the reaction system.
In addition, the properties such as density and boiling point of the compound, although not detailed, are also key parameters under specific chemical processes and research scenarios, related to the setting of reaction conditions, product separation strategies, etc. The various physical properties are interrelated and together constitute the unique physical properties of 2-bromo-5-hydroxypyridine, providing indispensable information for chemists when studying and applying this compound.

2 - Bromo - 5 - hydroxypyridine is an organic compound with many unique chemical properties.
First, it is acidic because it contains hydroxyl groups (-OH). The high electronegativity of oxygen atoms in the hydroxyl group makes the hydrogen-oxygen bond electron cloud biased towards oxygen, and hydrogen is easily dissociated in the form of protons, so it can react with bases, such as strong bases such as sodium hydroxide, to generate corresponding salts and water. This acidic property can be used in organic synthesis to build specific acid-base reaction systems and assist in the preparation of certain compounds.
Secondly, the bromine atom (-Br) in the molecule is active and can participate in nucleophilic substitution reactions. Nucleophiles (such as alkoxides, amines, etc.) can attack the carbon atoms connected to bromine, and bromine leaves with a pair of electrons to form new compounds. Like reacting with sodium alcohol, corresponding ether compounds can be formed; reacting with amines, nitrogen-containing substituted products can be obtained. This property is widely used in the fields of medicinal chemistry and materials science, and is often used to introduce specific functional groups to modify the properties of compounds.
Furthermore, the pyridine ring of the compound is aromatic, giving it a certain stability. However, the electron cloud distribution on the pyridine ring changes due to the substitution of bromine and hydroxyl groups, resulting in different reactivity at different positions on the pyridine ring. Usually, the activity of carbon atoms adjacent to or relative to bromine or hydroxyl groups in electrophilic substitution reactions will be affected, providing the possibility for the selectivity of related reactions. For example, in electrophilic substitution reactions such as halogenation and nitrification, the reaction check point will vary depending on the localization effect of the substituent.
In addition, 2-Bromo-5-hydroxypyridine may also participate in some redox reactions. Hydroxyl groups can be oxidized under the action of appropriate oxidants to form carbonyl groups or other oxygen-containing functional groups with higher valence states; while bromine atoms may be reduced and removed under certain reduction conditions, or converted into other bromine-containing species with low-priced states. These redox reactions provide rich strategies for the construction of complex compounds in the design of organic synthesis routes. In conclusion, the diverse chemical properties of 2-Bromo-5-hydroxypyridine make it play an important role in many fields such as organic synthesis and drug discovery.

A common method for the synthesis of 2-bromo-5-hydroxypyridine, usually starting from a compound containing a pyridine structure. One method starts with 5-hydroxypyridine and reacts it with a brominating agent. Among them, liquid bromine or N-bromosuccinimide (NBS) are often the choice for bromination. If liquid bromine is used, in a suitable solvent such as dichloromethane, at low temperatures and catalyzed by catalysts such as iron powder or iron tribromide, a bromination reaction can occur at a specific position on the pyridine ring of 5-hydroxypyridine to obtain 2-bromo-5-hydroxypyridine. In this reaction, the catalyst promotes the polarization of bromine molecules, making it easier to undergo electrophilic substitution with the pyridine ring, and the 5-hydroxy group has an impact on the reaction localization, so that the bromine tends to be substituted at the 2 position.
Another method starts from 2-bromopyridine. First, the 2-bromopyridine is properly protected to prevent the bromine atom from being affected in the subsequent reaction. After that, the hydroxyl group is introduced at the 5 position of the pyridine ring by a suitable method. Hydroxyl groups can be introduced by reacting with hydroxyl-containing reagents through metal-organic reagents, such as Grignard reagents or lithium reagents. For example, the Grignard reagent of 2-bromo-pyridine is prepared, and then reacted with suitable hydroxylation reagents such as borate esters. 5-hydroxy groups can be obtained by hydrolysis, and the target product 2-bromo-5-hydroxypyridine can be obtained after removing the protective group.
In addition, other pyridine derivatives containing suitable substituents can be gradually introduced into bromine and hydroxyl groups through multi-step reactions. According to the required reaction conditions and reagents, the reaction route is cleverly designed to obtain 2-bromo-5-hydroxypyridine.

2-Bromo-5-hydroxypyridine, this compound has important applications in many fields such as medicine, pesticides, and materials science.
In the field of medicine, due to its unique chemical structure, it has potential biological activity. It can be used as a key intermediate for the synthesis of specific pharmacological active compounds. If it can be converted into drug molecules with high affinity and selectivity for specific disease targets through a series of chemical reactions. Studies have shown that some synthetic derivatives based on 2-bromo-5-hydroxypyridine show inhibitory effects on tumor cell proliferation and are expected to be developed as new anti-cancer drugs; in the research and development of drugs for neurological diseases, the structure of the compound may also be modified to obtain drugs with regulatory functions on neurotransmitter receptors, providing new ideas for the treatment of Parkinson's disease and Alzheimer's disease.
In the field of pesticides, 2-bromo-5-hydroxypyridine can be used as a raw material for synthesizing highly efficient and low-toxic pesticides. After chemical modification, the synthesized pesticides may have strong toxic effects on specific pests, and are environmentally friendly and have low residues. For example, specific insecticides can be designed to target piercing mouthpart pests, such as aphids and leafhoppers, by interfering with the physiological and metabolic processes of pests, to achieve efficient control and contribute to sustainable agricultural development.
In the field of materials science, this compound can participate in the preparation of functional materials. For example, in the synthesis of organic optoelectronic materials, 2-bromo-5-hydroxypyridine can be introduced into conjugated systems to regulate the electronic structure and optical properties of materials. After rational molecular design and synthesis process optimization, organic Light Emitting Diode (OLED) materials with high fluorescence quantum yield and good charge transfer performance can be prepared for display technology to improve display screen brightness, contrast and color saturation. In terms of sensor materials, high-sensitivity and high-selectivity chemical sensors can be constructed by using their chemical reactions or interactions with specific substances to detect environmental pollutants, biomarkers, etc.

The market price of 2-bromo-5-hydroxypyridine fluctuates for many reasons. This compound is used in chemical, pharmaceutical and other fields, and its demand and supply conditions have a great impact on prices.
In the chemical industry, it is often a raw material for synthesizing other types of organic compounds. If the relevant chemical industry expands, the demand for it increases, and the price may rise; conversely, the industry shrinks, the demand decreases, and the price may fall.
In the pharmaceutical field, it may be involved in drug research and development and production. If a new drug is successfully developed, and it is used as a key intermediate, the demand will increase sharply, and the price will rise; if the research and development process is blocked, the demand will not increase, and the price will not change significantly. < Br >
Furthermore, the availability of raw materials also affects its price. If the raw material for preparing 2-bromo-5-hydroxypyridine is sufficient and the price is low, the production cost will drop, and the market price may drop accordingly; if the supply of raw materials is short, the cost will rise, and the price will also rise.
Production technology and process also have a great impact on cost and output. If new production technology can improve yield, reduce energy consumption, and reduce costs, there is room for price reduction; if there is no technological breakthrough, it will be difficult to reduce prices if high-cost production is maintained.
Market competition is also a major factor. There are many suppliers, and the competition is fierce. In order to occupy market share, there may be price cuts. If there are few suppliers, it is a monopoly, and the price may be high.
To know the exact market price, check the chemical product trading platform, inquire from suppliers, or refer to industry reports to obtain the latest and accurate price information.