2-Bromo-5-(hydroxymethyl)pyridine

2-Bromo-5- (hydroxymethyl) pyridine, which is an important compound in organic chemistry. Its physical properties are unique and related to many chemical processes and applications.
Looking at its properties, under normal temperature and pressure, it mostly shows a white to light yellow crystalline powder state, which is easy to identify and preliminarily judge.
The melting point is also key. It has been experimentally determined that it is about a specific temperature range, and this melting point data is of great significance for its purification, identification and stability research under different temperature conditions.
In terms of solubility, it has a certain solubility in common organic solvents, such as ethanol and dichloromethane, but its solubility in water is relatively limited. This property determines its reaction feasibility and separation method in different solvent systems.
As for density, although it is not a daily perceptible property, it provides basic data for calculating the proportion of reactive materials and solution concentration in chemical production and theoretical research.
In terms of volatility, the compound is less volatile, which makes it unnecessary to worry too much about material loss or environmental pollution due to volatilization during storage and operation.
In addition, its odor is relatively mild, without strong pungent or special odor, creating a relatively comfortable environment for actual operation and use.
The various physical properties are interrelated and jointly affect the application of 2-bromo-5- (hydroxymethyl) pyridine in organic synthesis, drug development and other fields. Knowing these properties is the basis for the rational use of this compound, and also provides indispensable information for scientific research and production in related fields.

The common synthesis methods of 2-bromo-5- (hydroxymethyl) pyridine are as follows.
One is to use 5- (hydroxymethyl) pyridine as the starting material, in a suitable solvent, under the action of brominating reagents. Among them, brominating reagents such as bromine and N-bromosuccinimide (NBS) are commonly used. If bromine is used, the reaction needs to be carried out at a low temperature and catalyzed by an appropriate catalyst such as iron powder. When NBS is used as the brominating agent, the reaction conditions are relatively mild, and the reaction is usually promoted under heating or light conditions in an inert solvent such as carbon tetrachloride. The key to this approach lies in the acquisition of the starting material 5- (hydroxymethyl) pyridine, which can be prepared by specific reactions of pyridine derivatives.
Second, 2-bromopyridine can be used to synthesize the target product by introducing hydroxymethyl groups. First, 2-bromopyridine is reacted with suitable reagents to form an intermediate with an active check point, and then reacts with hydroxymethyl-containing reagents. For example, 2-bromopyridine is first prepared into the corresponding Grignard reagent, and then reacted with hydroxymethylation reagents such as formaldehyde. After subsequent steps such as hydrolysis, 2-bromopyridine can be obtained. In this process, the preparation of Grignard reagent requires strict conditions such as anhydrous and anoxic, and the control of subsequent reaction steps is also crucial to ensure the purity and yield of the product.
Furthermore, the target molecular structure can be gradually constructed through multi-step reaction starting from the parent pyridine. First, the substituent is introduced into the pyridine ring at the appropriate position, and then the bromine atom and hydroxymethyl are introduced in sequence. Although this strategy is a little complicated, the synthesis route can be flexibly adjusted according to different reaction conditions and reagent selection to adapt to the preparation of different scales and purity requirements.

2-Bromo-5- (hydroxymethyl) pyridine, which has a wide range of uses and is a key intermediate in the field of medicinal chemistry. Taking the creation of new antibacterial drugs as an example, it can be cleverly combined with other compounds through specific reaction steps to build a molecular structure with antibacterial activity. Pharmaceutical developers regard it as a precious cornerstone, and by chemically modifying it, they can obtain better antibacterial drugs with less side effects.
In the field of materials science, 2-bromo-5- (hydroxymethyl) pyridine has also emerged. When preparing special functional polymer materials, it can be used as a reactive monomer to participate in polymerization reactions. The resulting materials may have unique physical and chemical properties, such as good solubility and thermal stability, and may have extraordinary applications in the fields of electronic devices, optical materials, etc.
Furthermore, in the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can use the active reactivity of bromine atoms and hydroxymethyl groups to design a variety of synthetic pathways to prepare many organic compounds with complex structures and specific functions according to their structural characteristics, which contribute to the development of organic synthetic chemistry. In short, 2-bromo-5- (hydroxymethyl) pyridine has important value in many fields such as medicine, materials, and organic synthesis, and promotes the continuous progress of related science and technology.

I have not obtained the market value of 2 - Bromo - 5 - (hydroxymethyl) pyridine. However, according to the theory of "Tiangong Wuwu", I can slightly deduce it.
The determination of the market is determined by general factors. One is the raw material. If the raw material of this compound is easy and inexpensive to obtain, it may not be high or not; on the contrary, if the raw material is scarce and sought, it must be high. Second, it is easy to produce. If the method is not developed, it requires as delicate and elegant tools, and it will take a long time, the cost will increase, and the market price will also be high. Third, supply and demand in the market. If the demand is low, the supply is limited, and the supply is limited; if the supply is limited, the supply will drop.
And the name of this compound contains groups such as "hydroxymethyl" and "bromo", or it is not easy to do, and the raw materials used may also be obtained. However, I do not know what the demand for it is in the market. If it is widely used, such as in the fields of manufacturing, chemical industry, etc., it is indispensable, and the demand is large and the supply is increasing rapidly, and its price is high or high.
However, it has not been researched in the market, and its price is determined. Or ten dollars per gram, or hundreds of dollars per gram, it is possible. Only by checking the market, the cost of raw materials, and the supply and demand of the method can we obtain the approximate market value.

2-Bromo-5- (hydroxymethyl) pyridine is an organic compound. When storing and transporting, the following things must be paid attention to.
Its nature or activity, in case of heat, open flame or oxidant, may cause violent reaction and risk of explosion. Therefore, when storing, it is advisable to choose a cool, dry and well-ventilated place, away from fire and heat sources, and store it separately from oxidants, acids and alkalis, and must not be mixed. The warehouse must be equipped with suitable materials to contain leaks.
When transporting, also need to be cautious. The packaging must be stable to ensure that it will not be damaged or leaked during the journey. The transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. Driving routes should avoid densely populated areas and traffic arteries. During transportation, they should be protected from exposure to the sun, rain, and high temperature. When loading and unloading, the operation must also be careful, and the light handling should be carried lightly to avoid damage to the packaging and material leakage.
In addition, 2-bromo-5- (hydroxymethyl) pyridine may have certain toxicity and irritation, and pose potential hazards to human health. Storage and transportation personnel should take protective measures, wear protective clothing, protective gloves and goggles, and avoid direct contact. If they accidentally come into contact, they should be handled according to emergency measures, and in severe cases, they should be sent to the hospital quickly. In this way, the safety of storage and transportation can be guaranteed to avoid accidents.