2-Bromo-5-formylpyridine

2-Bromo-5-formylpyridine is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in pharmaceutical chemistry, this compound can be used as a starting material for the creation of new drugs. Because it contains both bromine atoms and formyl groups in its molecules, this difunctional group has high reactivity. Bromine atoms can participate in nucleophilic substitution reactions, while formyl groups can be converted through various reaction pathways, such as reduction to hydroxyl groups, oxidation to carboxyl groups, or condensation reactions with nucleophilic reagents containing nitrogen and sulfur. This can build a complex drug molecular skeleton and lay the foundation for the development of drugs with specific biological activities.
Second, in the field of materials science, 2-bromo-5-formylpyridine can be used to synthesize functional materials. For example, by reacting with specific organic ligands, metal-organic framework (MOFs) materials are prepared. Such materials have potential applications in gas adsorption and separation, catalysis, etc. due to their unique pore structure and excellent physicochemical properties. Its bromine atom and formyl group can participate in coordination chemistry processes to regulate the structure and properties of materials.
Furthermore, in the field of organic optoelectronic materials, this compound can be chemically modified to introduce conjugated structural units to synthesize materials with specific optical and electrical properties. Due to the presence of formyl and bromine atoms, the electron cloud distribution and energy level structure of the molecule can be adjusted, so that the material can play a role in Light Emitting Diode (LED), solar cells and other devices, and improve the photoelectric conversion efficiency and stability of the device.
In summary, 2-bromo-5-formylpyridine is an important basic compound in many fields such as drugs and materials due to its unique structure and active functional group, which is of great significance for promoting scientific research and technological development in related fields.

The synthesis method of 2-bromo-5-formylpyridine has been known for a long time. One common way of synthesis is to use pyridine derivatives as the starting material and prepare it through multi-step reaction. If 2-bromo-pyridine is used as the base, a suitable protective group is introduced first to prevent subsequent reaction interference. After metallization, the specific position of the pyridine ring is activated, and then it interacts with the corresponding aldehyde-based reagents, such as N, N-dimethylformamide (DMF), etc. Under suitable reaction conditions, formyl groups can be introduced to obtain 2-bromo-5-formylpyridine. In this process, the control of reaction conditions is extremely critical, such as reaction temperature, time, and the proportion of reagents used, all of which will affect the yield and purity of the product.
Second, the target product can be obtained by bromination from 5-formylpyridine. In this process, suitable brominating reagents, such as N-bromosuccinimide (NBS), need to be selected, and the reaction is carried out in an appropriate solvent under the action of a catalyst. During the reaction, attention should be paid to the reaction process to prevent excessive bromination and affect the quality of the product.
There are also other heterocyclic compounds as starting materials, which are synthesized through complex cyclization and functional group transformation. In short, there are various methods for synthesizing 2-bromo-5-formylpyridine, and it is necessary to weigh the advantages and disadvantages of each method according to the actual needs, and choose the appropriate method to achieve the purpose of efficient and high-quality synthesis.

2 - Bromo - 5 - formylpyridine is an organic compound, and its physical properties are quite important. Looking at its appearance, at room temperature and pressure, this substance is often a light yellow to brown solid, with a fine texture, resembling powder or crystalline, like finely crushed jade.
When it comes to the melting point, it is usually in a specific temperature range, about [X] ° C. The characteristics of the melting point are like the "temperature code" of the substance. At this temperature, the solid will gradually turn into a liquid, just like ice melting in the warm sun. The value of the melting point is of great significance for the identification and purity determination of the compound. Accurate determination of the melting point can distinguish the purity.
In terms of boiling point, under specific pressure conditions, it is about [X] ° C. The boiling point is similar to the "rising temperature" of a substance. At this temperature, the liquid will be violently vaporized and turned into a gaseous state to disperse. The determination of the boiling point can help chemists understand the state changes of the compound at different temperatures. In the process of separation and purification, the knowledge of boiling point is very useful.
In terms of solubility, 2-Bromo-5-formylpyridine exhibits different solubility in organic solvents. In common organic solvents such as dichloromethane and chloroform, it has good solubility, just like fish swimming in water and can disperse evenly. However, in water, its solubility is poor, as if oil floats on the water surface and is difficult to blend. This solubility characteristic plays a key guiding role in the selection of solvents for organic synthesis reactions, allowing chemists to select suitable solvents to make the reaction proceed smoothly.
Density is also one of its important physical properties, and its density is about [X] g/cm ³. This value indicates that the weight of this substance is compared with reference substances such as water of the same volume. In practical operations such as storage and transportation, density considerations are indispensable.
In addition, 2-Bromo-5-formylpyridine has a certain degree of volatility. Although the volatility is not strong, it will evaporate slowly in a specific environment. Its odor is unique. Although it is not pungent, it is also unique. During operation, this volatility and odor characteristics require chemists to pay attention and take protective measures. In summary, the many physical properties of 2-Bromo-5-formylpyridine play an important role in the research and practical application of organic chemistry.

2-Bromo-5-formylpyridine is one of the organic compounds with unique chemical properties. In its structure, the bromine atom and the formyl group are located at a specific position in the pyridine ring, which gives the compound many characteristics.
First of all, it contains an aldehyde group, that is, a formyl group, which has typical aldehyde chemical properties. The aldehyde group can participate in the oxidation reaction. When it encounters weak oxidants such as Torun reagent, it can be oxidized to carboxyl groups to form 2-bromo-5-pyridinecarboxylic acid; when it encounters strong oxidants, it can also be oxidized, and the product depends on the reaction conditions. At the same time, the aldehyde group can undergo a reduction reaction and be treated with a suitable reducing agent, which can be converted into an alcohol hydroxyl group to obtain 2-bromo-5- (hydroxymethyl) pyridine.
Furthermore, it contains a bromine atom, and this halogen atom endows the compound with halogenated hydrocarbon-related properties. In the nucleophilic substitution reaction, the bromine atom can be replaced by a variety of nucleophilic reagents. For example, in the reaction with sodium alcohol, the bromine atom can be replaced by an alkoxy group to form a corresponding ether compound; in the reaction with amines, nitrogen-containing derivatives can be formed.
In addition, the pyridine ring also has an effect on the properties of the compound. Pyridine ring has a certain alkalinity, because it has lone pair electrons This basic property makes 2-bromo-5-formylpyridine exist in different forms under specific acid and base conditions, which affects its reactivity and solubility.
Because the pyridine ring is a conjugated system, the whole molecule has a certain stability. But at the same time, the conjugation effect also affects the electron cloud distribution of aldehyde and bromine atoms, which in turn affects the reactivity of the two. In some reactions, the pyridine ring can be used as an electron receptor or donor to participate in the electron transfer process, affecting the reaction mechanism and product structure.
In summary, the interaction of 2-bromo-5-formylpyridinal aldehyde, bromine atom and pyridine ring exhibits diverse chemical properties and has important application value in the field of organic synthesis.

The price of 2-bromo-5-formylpyridine in the market is difficult to determine. This is due to the ever-changing market conditions, and the price changes with many reasons. The price may vary due to the wide and narrow supply of goods, the simplicity of the process, and the different demands.
In the past, if the supply is abundant, the process is easy to make, and there are few people seeking it, the price may be low. However, if the supply is scarce, the process is complicated, and there are many people seeking it, the price will be high.
In chemical markets, the price of common materials may range from a few yuan to tens of yuan per gram. However, 2-bromo-5-formylpyridine is not a common material, and its price may exceed this. If you buy it from a merchant specializing in chemical raw materials, the price may be better than the average price in the market. However, it also depends on the amount. If you buy a large amount, you may get a discount.
Furthermore, the global market also has an impact. If the production outside the region changes, or the local price changes. In addition, taxes and transportation can make the price different. Therefore, if you want to know the exact price, it is advisable to consult the chemical raw material supplier or visit the platform for inter-market transactions to get a real-time price.