2-Bromo-5-fluoro-pyridine

2-Bromo-5-fluoropyridine is a crucial chemical substance in the field of organic synthesis. It has a wide range of uses and plays a key role in many fields.
First, in the field of medicinal chemistry, it is often used as a key intermediate. The synthesis of many drugs depends on the construction of specific molecular structures to obtain the required biological activity. Because of its unique chemical structure, it can interact with specific targets in organisms, laying the foundation for the development of new drugs. For example, in the development of anti-tumor drugs, by modifying and derivatizing their structures, new anti-cancer drugs with better efficacy and less side effects can be created.
Second, in the field of pesticide chemistry, 2-bromo-5-fluoropyridine also plays an important role. It can be used to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. Such pesticides can precisely act on pests, effectively prevent and control pests and diseases, ensure the yield and quality of crops, and reduce the adverse impact on the environment, which is in line with the needs of modern green agriculture development.
Third, it also has its application in the field of materials science. It can be used as a starting material for the synthesis of functional materials. Through specific chemical reactions, the materials are endowed with unique optical, electrical or mechanical properties, providing the possibility for the development of new functional materials. Fields such as optoelectronic materials and polymer materials may benefit from this.
In summary, 2-bromo-5-fluoropyridine, due to its unique chemical properties, plays an indispensable role in many fields such as medicine, pesticides, and materials science, promoting the sustainable development and progress of related fields.

To prepare 2-bromo-5-fluoropyridine, there are three methods. One is halogenation, using 5-fluoropyridine as the starting material, in a suitable solvent, such as dichloromethane, with N-bromosuccinimide (NBS) as the bromine source, in the presence of an initiator, such as benzoyl peroxide, heating or lighting, so that the 2-hydrogen of 5-fluoropyridine is replaced by bromine to obtain the product. This process requires temperature control to prevent the formation of polybrominates.
The second is the diazotization method. First, 5-fluoropyridine is co-heated with nitric acid and sulfuric acid to obtain 5-fluoro-2-nitropyridine. After reduction with iron powder, hydrochloric acid or lithium aluminum hydride, 5-fluoro-2-aminopyridine is obtained. After that, it is formed into diazonium salt at low temperature with sodium nitrite and hydrochloric acid, and then reacts with cuprous bromide. The diazo group is replaced by bromine to obtain 2-bromo-5-fluoropyridine. There are many steps in this process, and the operation needs to be cautious. Low temperature is the key to diazotization.
The third is the palladium-catalyzed coupling method, in which 5-fluoropyridine halides, such as 5-fluoro-2-chloropyridine, are reacted with brominating reagents, such as organobrominated zinc, in a palladium catalyst, such as tetra (triphenylphosphine) palladium (0) and with the assistance of ligands, in an organic solvent with a suitable base, such as potassium carbonate, to achieve chlorine substitution with bromine to obtain the target product. This method has good selectivity, but the catalyst cost is high.

2-Bromo-5-fluoropyridine, an organic compound, is widely used in the chemical and pharmaceutical fields. It has unique physical properties. In order to explore its characteristics, it is described in ancient Chinese as follows.
Looking at its properties, at room temperature, 2-bromo-5-fluoropyridine is often colorless to light yellow liquid with clear texture. Its smell is unique, but it is not pungent and intolerable. In well-ventilated places, the smell is tolerable. Its boiling point is quite critical. It has been experimentally determined to be in a certain temperature range. This temperature makes it change from liquid to gaseous state. The characteristics of this boiling point are significant when separating and purifying the compound. By controlling the temperature and taking advantage of its boiling point difference, 2-bromo-5-fluoropyridine can be precisely extracted from the mixture.
Furthermore, when it comes to the melting point, this compound also has a specific value. Under specific low temperature conditions, 2-bromo-5-fluoropyridine condenses from liquid to solid. The nature of this melting point has a great impact on its storage and transportation. Knowing the melting point can ensure that it can be stored at a suitable temperature environment to prevent abnormal changes in its state and affect the quality and use.
Solubility is also one of the important physical properties. In organic solvents, such as some common organic solvents, 2-bromo-5-fluoropyridine exhibits good solubility and can be fused with solvents. However, in water, its solubility is relatively limited. This difference in solubility needs to be considered in detail during chemical synthesis and reaction operations. Choosing a suitable solvent can not only promote the smooth progress of the reaction, but also improve the purity and yield of the product.
In addition, the density of 2-bromo-5-fluoropyridine is also one of its characteristics. Its density is different from that of water, and this density difference can be used as an important basis for judgment when mixing, delamination and other operations are involved. By observing its stratification with water or other liquids, its purity and content can be preliminarily judged.
In summary, the physical properties of 2-bromo-5-fluoropyridine, such as properties, odor, boiling point, melting point, solubility and density, play a crucial role in its application in chemical and pharmaceutical fields. In-depth understanding and skilled use of these properties can better exert their value and promote the development of related fields.

2-Bromo-5-fluoropyridine, this product is in the market, its price varies from time to time, and it also varies with the quality and quantity purchased. Looking at the market conditions in the past, if the quantity is small, the price of bulk buying is often high. It is difficult to cover the preparation, the process is complicated, and the materials used are also special, resulting in a high cost.
In the past, in ordinary reagent stores, the price per gram was purchased in small quantities, or up to tens of gold. If it is used for scientific research, the quantity is small and the fine is required. Although the price is high, it is helpless. However, if the merchant asks for the quantity and buys it in bulk, the price per gram may be slightly reduced after bargaining.
And the number of suppliers in the market also affects its price. If there are many producers and fierce competition, the price may decline in order to compete for the market; conversely, if the producers are thin and the supply is tight, the price will rise. In addition, the current situation, the source of materials, etc., all have an impact. If there is a shortage of materials, or a change in government orders, the preparation is limited, and the price fluctuates.
To know the real-time price, when consulting chemical reagent suppliers, or visiting professional chemical product trading platforms, you can get accurate numbers for business and scientific research needs.

2-Bromo-5-fluoropyridine is an organic compound with specific chemical activity and physical properties. When storing and transporting, many matters need careful attention.
First words storage. Because of its chemical activity, it should be stored in a cool, dry and well-ventilated place. If the temperature is too high, it may cause the compound to decompose and deteriorate, and even cause safety accidents. High humidity may cause it to get damp, which affects the quality. Keep away from fire and heat sources to prevent fire. In addition, it should be stored separately from oxidizing agents, acids, bases, etc., which are in contact with them and are prone to chemical reactions and endanger safety. Emergency treatment equipment and suitable containment materials should be provided in the storage place in case.
Times and transportation. Before transportation, the packaging must be tight to ensure that there is no risk of leakage. The packaging materials selected should be able to resist vibration, collision and friction, and do not react with compounds. During transportation, drivers and escorts should be familiar with its nature and emergency treatment methods. Vehicles should be equipped with fire equipment and leakage emergency treatment equipment. Driving routes should avoid densely populated areas and important facilities. In case of emergencies such as leaks, they can be properly handled in a timely manner to reduce damage hazards.
The storage and transportation of 2-bromo-5-fluoropyridine is related to safety and quality. All links must be operated in strict accordance with regulations and must not be sloppy in order to ensure foolproof.