2-Bromo-5-chloro-pyridine

2-Bromo-5-chloropyridine is one of the organic compounds. Its physical properties are worth exploring. Looking at its appearance, under room temperature and pressure, it is mostly white to pale yellow crystalline powder. This characteristic of color can be an important evidence for identifying this substance.
As for the melting point, it is about 55-59 ° C. The melting point is also the critical temperature at which a substance changes from solid to liquid. Such a specific melting point range can be used to identify the compound and measure its purity. When the substance is heated to this temperature range, the force between the molecules changes, and the lattice structure gradually disintegrates, and then it melts from solid to liquid. < Br >
The value of the boiling point is about 244 ° C. The boiling point is the temperature at which the saturated vapor pressure of the liquid is equal to the external pressure. At this temperature, a large number of bubbles form and escape inside the liquid. The boiling point of 2-bromo-5-chloropyridine determines the conditions for separation operations such as distillation.
Furthermore, its density is about 1.714g/cm ³. In terms of density, the mass of the substance per unit volume is also. This value indicates that it is a heavier substance than water, and the density factor cannot be ignored in the process involving liquid-liquid separation or mixing.
In terms of solubility, 2-bromo-5-chloropyridine is insoluble in water. Water is a common solvent. However, the interaction between this substance and water molecules is weak, so it is insoluble. However, it is soluble in organic solvents such as dichloromethane, chloroform, ethanol, ether, etc. In the field of organic synthesis, it is crucial to choose a suitable solvent. Its solubility characteristics determine which solvent system can better react in order to achieve the desired synthesis target.

2-Bromo-5-chloro-pyridine is an organic compound with many unique chemical properties. Among this compound, bromine (Br) and chlorine (Cl) are halogen atoms, giving them significant chemical activity.
As far as nucleophilic substitution is concerned, halogen atoms can be replaced by nucleophilic reagents. Due to this, 2-Bromo-5-chloro-pyridine can react with a variety of nucleophilic reagents, such as alkoxides, amines, etc. Due to the electron-absorbing properties of halogen atoms, the electron cloud density of the pyridine ring decreases, making the electrophilic substitution reaction on the ring more difficult. However, if the conditions are suitable, electrophilic substitution reactions can also occur, but usually more severe reaction conditions are required.
In alkaline environments, 2-Bromo-5-chloro-pyridine may undergo elimination reactions, where the halogen atom is separated from the hydrogen atom on the adjacent carbon atom to form a product containing double bonds. In addition, due to the presence of pyridine rings, this compound exhibits a certain alkalinity and can react with acids to form corresponding salts.
In addition, 2-Bromo-5-chloro-pyridine can participate in metal-catalyzed coupling reactions, such as synergistic coupling with palladium catalysts, with other organic halides or alkenyl halides to form carbon-carbon bonds, which is of great significance in the field of organic synthesis and is often used in the preparation of complex organic molecules and pharmaceutical intermediates. This compound has rich and diverse chemical properties and is widely used in the field of organic synthesis chemistry. It can be used to construct complex organic compounds through a variety of reaction pathways.

2-Bromo-5-chloropyridine is also an organic compound. Its common synthesis method is based on various chemical paths.
First, pyridine is used as the initial material. Chlorination is first applied to introduce chlorine atoms at specific positions on the pyridine ring. This chlorination method often requires appropriate chlorinated reagents, such as chlorine gas, sulfoxide chloride, etc., and under suitable reaction conditions, such as specific temperature, pressure and catalyst coexistence, the chlorine atoms can precisely fall on the specific check point of the pyridine ring to obtain chloropyridine-containing intermediates.
Then, the operation of bromination of this intermediate is carried out. The bromination process also requires careful selection of brominating reagents, such as bromine, N-bromosuccinimide (NBS), etc. Following the appropriate reaction conditions, the bromine atoms are connected to the predetermined position, and the final result is 2-bromo-5-chloropyridine. In this path, each step of the reaction requires fine regulation of the reaction conditions, such as the rise and fall of temperature, the length of the reaction time, and the proportion of the reactants, which are all related to the purity and yield of the product.
Second, other nitrogen-containing heterocyclic compounds are also used as starting materials and converted through multiple steps. However, these paths are often complicated and require fine planning of the reaction at each step. First, the functional group of the starting material is transformed to construct an intermediate similar to the structure of the target product, and then bromine and chlorine atoms are introduced one after another through halogenation and other reactions. In this process, it is necessary to understand the mechanism of each step of the reaction in order to ingeniously design the route and improve the efficiency and success rate of the synthesis.
In short, the synthesis of 2-bromo-5-chloropyridine requires a deep understanding of organic chemistry, familiarity with the characteristics of various reactions, careful selection of raw materials and reagents, and precise regulation of reaction conditions in order to achieve the expected synthetic effect.

2-Bromo-5-chloropyridine is useful in many fields. In the field of medicinal chemistry, it is often a key intermediate. Due to its unique structure, it can undergo a variety of chemical reactions to prepare various bioactive compounds. For example, when developing new antimicrobial drugs, using this as the starting material and through clever synthesis paths, agents with excellent inhibitory effects on specific bacteria can be prepared.
It is also very important in pesticide chemistry. It can be used to build the molecular structure of pesticides and obtain pesticide products with high insecticidal, bactericidal or herbicidal properties. For example, insecticides that target some stubborn pests can be derived, and the impact on the environment is relatively small, which is in line with the current trend of green pesticide development.
In the field of materials science, 2-bromo-5-chloropyridine is also involved. It may participate in the synthesis of organic semiconductor materials, which have potential applications in electronic devices such as organic Light Emitting Diodes (OLEDs) and organic field effect transistors (OFETs). Its structure can endow materials with unique electrical and optical properties, providing new opportunities for the development of high-performance electronic materials.
Furthermore, in chemical research, as a special pyridine derivative, it provides an excellent substrate for the study of organic synthesis methodologies. Chemists can use this to explore novel reaction mechanisms, optimize reaction conditions, and then promote the development of organic chemistry theory and practice. In conclusion, 2-bromo-5-chloropyridine has shown important application value and potential in many fields such as medicine, pesticide, materials and chemical research.

The market price range of 2-bromo-5-chloropyridine often varies due to various factors. Its price is related to the difficulty of the production process. The preparation of this compound requires delicate synthesis steps. If the process is complicated, the cost of raw materials is high and the steps are cumbersome, which will push up the price. The supply of raw materials is also the key. If the raw materials used are scarce or limited, the price will rise. Market demand also affects its price. If an industry has strong demand for it, when the supply exceeds the demand, the price will rise; conversely, if the demand is weak, the price will fall.
According to past market conditions and related transaction records, its price is roughly between tens of yuan and hundreds of yuan per gram. For a small amount of procurement, such as scientific research institutions for experimental needs, due to the small purchase volume, the unit price may be higher, or more than 100 yuan per gram, or even hundreds of yuan. If it is an industrial-scale purchase, due to the large quantity, the price can be negotiated with the supplier, and the unit price may be reduced to tens of yuan per gram.
However, the market changes, the price is not static. The advent of new production technologies can reduce production costs and make prices fall; if the supply of raw materials is blocked due to emergencies, or demand increases sharply, the price will rise. Therefore, in order to know the accurate price, it is necessary to pay attention to the market dynamics of chemical raw materials in real time and consult with suppliers in detail to obtain the exact price range at the moment.