2-Bromo-5-Amino-6-Methylpyridine

The physical properties of 2-% cyanogen-5-hydroxy-6-methylpyridine are as follows:
This compound is mostly solid at room temperature and has a certain crystalline form. The melting point is in a specific range, which depends on the strength of the intermolecular forces and the regularity of the crystal structure. Due to the existence of different groups such as cyano (-CN), hydroxy (-OH) and methyl (-CH 🥰) in the molecule, the intermolecular forces are more complex. The carbon-nitrogen triple bond in the cyanide group has strong polarity and can participate in the formation of strong dipole-dipole interactions, which will increase the melting point of the compound to a certain extent. Hydroxyl groups can form hydrogen bonds, and hydrogen bonds are relatively strong, which further increases the binding force between molecules and also contributes significantly to the increase in melting point.
Its boiling point is also dominated by intermolecular forces. Due to the strong interaction caused by cyanide and hydroxyl groups, the compound needs high energy to overcome the attractive forces between molecules and transform from liquid to gaseous state, so the boiling point is relatively high.
In terms of solubility, due to the hydrophilicity of hydroxyl groups, the compound theoretically has a certain solubility in water. However, the presence of cyanide and methyl groups increases the hydrophobicity of the molecule. Overall, in polar organic solvents such as ethanol and acetone, the solubility of the compound may be relatively good, because polar organic solvents can interact with the compound molecules through dipole-dipole interactions or hydrogen bonds to promote the dissolution process.
The appearance of the compound is often white or off-white, which is mainly due to the absorption and reflection characteristics of its molecular structure to visible light. The electron transition energy level in the molecule determines the absorption range of light. When the absorption is mainly concentrated in the ultraviolet region and the absorption of visible light is weak, it will appear white or off-white.
The density is related to the relative molecular mass of the molecule and the degree to which the molecule is packed tightly in the crystal or liquid state. The higher the relative molecular mass, the more tightly packed the molecules, the higher the density. The relative molecular mass of this compound is determined by the sum of the relative atomic masses of each atom. At the same time, the intermolecular forces and the spatial structure affect the way the molecules are packed, which affects the density.

2-% cyanogen-5-hydroxy-6-methylpyridine, this material is unique. It is acidic, and the edge hydroxyl group can release protons, and can form salts in alkali solutions. It is also alkaline, and the nitrogen atom of the pyridine ring has lone pairs of electrons, which can form salts with acids, showing the sign of amphotericism.
Its chemical activity is quite high. Hydroxyl groups can be involved in esterification reactions, and can be encountered with acid chlorides and acid anhydrides to form ester compounds. Cyanyl groups are also highly active and can be hydrolyzed into carboxyl groups. Under suitable conditions, after a series of reactions, carboxyl-containing derivatives can be obtained. Or after reduction, it is converted into amino groups, and the reactions are diverse. < Br >
The methyl group is attached to the pyridine ring, which affects the distribution of molecular electron clouds, causing its reaction check point and activity to be different from that of the pyridine body. This substance has a wide range of uses in the field of organic synthesis, and is a key intermediate for the preparation of complex organic substances, or the creation of drugs, pesticides, and functional materials.
Because of its special chemical properties, it is necessary to follow the norms and take appropriate protection measures during operation. Cyanide is highly toxic, beware of leakage and contact, and ensure the safety of experiments.

To prepare 2-bromo-5-hydroxy-6-methylpyridine, the common synthesis method is as follows:
The starting material can be selected from suitable pyridine derivatives, such as 2-methyl-5-nitropyridine as the starting material. First, 2-methyl-5-nitropyridine is reduced to convert the nitro group into an amino group. The common reducing agent in this step is iron filings and hydrochloric acid. Iron filings react with hydrochloric acid to form ferrous ions, which can gradually reduce the nitro group to an amino group to obtain 2-methyl-5-aminopyridine.
Then 2-methyl-5-aminopyridine is brominated. 2-methyl-5-aminopyridine is dissolved in a suitable solvent, such as glacial acetic acid, and bromine is slowly added dropwise at low temperature. The positioning effect of the amino group makes the bromine atom mainly substituted in the ortho or para-position of the pyridine cyclic amino group. Under this reaction condition, the bromine atom can be introduced at the appropriate position to generate 2-bromo-5-amino-6-methylpyridine.
Then 2-bromo-5-amino-6-methylpyridine is diazotized. Dissolve it in dilute sulfuric acid and add sodium nitrite solution at low temperature to form a diazonium salt. The diazonium salt is unstable and the next step needs to be carried out immediately.
Finally, hydrolysis is carried out to convert the diazonium group into a hydroxyl group. Heating or adding a suitable catalyst, such as copper sulfate, can be used to promote the hydrolysis of the diazonium group, and finally 2-bromo-5-hydroxy-6-methylpyridine is obtained.
Or 5-methyl-2-pyridinone is used as the starting material. First, 5-methyl-2-pyridinone is brominated. Under suitable reaction conditions, bromine atoms are introduced into the pyridine ring to obtain 5-methyl-6-bromo-2-pyridinone. Then through suitable nucleophilic substitution reaction, the oxygen atom of pyridinone is replaced with a hydroxyl group, while maintaining the position of bromine atom and methyl group. After a series of reaction operations, the target product 2-bromo-5-hydroxy-6-methyl pyridine can also be obtained. These two methods have their own advantages and disadvantages. In actual operation, the selection needs to be comprehensively considered according to the availability of raw materials and the difficulty of reaction conditions.

2-%-5-amino-6-methylpyridine is an important organic compound that is widely used in many fields.
In the field of medicine, it is often a key intermediate in the synthesis of drugs. Due to its specific chemical structure, it can be chemically modified to synthesize compounds with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, 2-%-5-amino-6-methylpyridine is used as the starting material, and through a series of chemical reactions, drug molecules with antibacterial functions are constructed to help fight bacterial infections.
In the field of pesticides, this compound also plays an important role. It can be used to develop new types of pesticides, and by modifying its structure, the pesticide is given specific insecticidal, bactericidal or herbicidal activities. For example, the design of insecticides for specific pests interferes with the physiological activities of pests by combining with specific targets in the body of pests, achieving the purpose of insecticidal, and providing an effective means for pest control in agricultural production.
In the field of materials science, 2-% -5-amino-6-methylpyridine can be used as a raw material for the synthesis of special functional materials. After polymerization or blending with other compounds, materials with specific electrical, optical or mechanical properties are prepared. For example, the synthesis of polymer materials with good electrical conductivity is used in the field of electronic devices; or the synthesis of materials with fluorescent properties is used in optical sensing or biological imaging.
In addition, in the study of organic synthesis chemistry, 2-%-5-amino-6-methylpyridine is often used as an important reaction substrate for the development of novel organic synthesis methods due to its unique functional groups and reactivity.

Today there is dicyanopentaminohexamethylpyridine, what is the price of its market? This is the high and low of things, and it is related to many things.
First of all, the condition of occurrence is important. If this thing is born in a prosperous place, the transportation is convenient, it is easy to gather and disperse, and it is less expensive to transport, the price is flat. If it is produced in remote soil, the road is blocked and long, and it is difficult to lose, the cost will be more, and the price will also be high because of it.
Second, the quality of the quality determines the price. The quality is pure and flawless, and it is good for wide use. Those who seek it are numerous, and the price will be high. If it is miscellaneous but impure, there is a lack of use, and people may discard it, the price will
Furthermore, the supply and demand of the city determines its price. There are many people in need, but there are few suppliers. Rare things are expensive, and the price must rise. If the supply exceeds the demand, the goods are accumulated in the city, and if they want to sell quickly, the price must be suppressed.
There is also the cost of regulation, which is also the reason for the price. To make this thing, the materials, effort and time required are all expensive. Materials are expensive and complex, and the cost will be high, and the price will also rise. If the method of making it is good, it can save materials and labor, and the cost will drop, the price may also be reduced.
As for the market price of this dicyanopentaminohexamethylpyridine, the actual situation is not detailed, and it is difficult to determine the exact number. It is necessary to review the condition of occurrence, quality, supply and demand, and cost of the system before we can know the approximate price. Or visit the cities of Jia and consult the operators, and you can also know the price.