2-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2 - Bromo - 5 - (4,4,5,5 - tetramethyl - 1,3,2 - dioxaborolan - 2 - yl) pyridine, the Chinese name is often 2 - bromo - 5 - (4,4,5,5 - tetramethyl - 1,3,2 - dioxaborolan - 2 - yl) pyridine, this substance is widely used, in the field of organic synthesis, the role is particularly critical.
First, it is an important intermediate in the construction of complex pyridine compounds. Pyridine compounds are widely used in the fields of medicine, pesticides and materials. Through the Suzuki-Miyaura coupling reaction, the bromine atom of this compound and another borate-containing ester or boric acid compound can form carbon-carbon bonds under the action of palladium catalyst and base to synthesize pyridine derivatives with diverse structures. For example, when creating new anti-cancer drugs, the active fragments can be precisely spliced through this reaction to obtain pyridine compounds with specific pharmacological activities.
Second, in the field of materials science, it can be used to prepare optoelectronic materials. The pyridine structure and boroxy ring structure endow the material with unique optoelectronic properties. Through rational design of coupling with other conjugated units, the luminous wavelength and fluorescence quantum efficiency of the material can be regulated. For example, when preparing organic Light Emitting Diode (OLED) materials, it is used to build a conjugated system to improve the material's luminescence properties and achieve high-efficiency luminescence.
Third, in the research and development of pesticides, pyridine pesticides with high-efficiency biological activity can be synthesized. Pyridine compounds have significant control effects on a variety of pests. As an intermediate, this compound can introduce different substituents through multi-step reactions to optimize the molecular structure of pesticides, enhance the toxicity and selectivity to target pests, and reduce the impact on non-target organisms. At the same time, the development environment-friendly pesticides.

The synthesis of 2-bromo-5- (4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl) pyridine is of great interest in the field of organic synthetic chemistry. There are many synthetic paths, and the common ones are as follows.
First, the pyridine ring is functionalized at a specific position with 2-bromo pyridine as the starting material. Under suitable reaction conditions, the borate ester group is introduced at the 5-position of the pyridine ring. This process can be achieved by palladium-catalyzed cross-coupling reactions, such as the Suzuki reaction. Select suitable palladium catalysts, such as tetra (triphenylphosphine) palladium, etc., with alkali reagents, such as potassium carbonate, sodium carbonate, etc., in organic solvents, such as toluene, dioxane, etc., with 4, 4, 5, 5 - tetramethyl - 1, 3, 2 - dioxyboron heterocyclopentane - 2 - base related reagents for reaction. The reaction temperature needs to be precisely controlled, usually near the reflux temperature, after a certain period of time, the synthesis of the target product can be achieved.
Second, from pyridine derivatives, the structural unit containing boron atoms can be constructed first, and then bromine atoms can be introduced. For example, the pyridine intermediates containing 5- (4,4,5,5-tetramethyl-1,3,2-dioxoborocyclopentane-2-yl) are synthesized first, and then the 2-position of the pyridine ring is brominated in a suitable organic solvent in the presence of light or initiator, such as the use of brominating reagents, such as N-bromosuccinimide (NBS), to obtain the target product.
Third, boron reagents and bromopyridine derivatives are used as raw materials to synthesize by direct boronation catalyzed by transition metals. A suitable transition metal catalyst, such as copper catalyst, is selected to react with 2-bromopyridine derivatives under the synergistic action of ligands, and boron groups are directly introduced at the 5-position of the pyridine ring to form 2-bromopyridine - (4,4,5,5-tetramethyl-1,3,2-dioxyboronheterocyclopentane-2-yl) pyridine. This method needs to optimize the reaction conditions, such as temperature, catalyst dosage, ligand type, etc., to improve the reaction yield and selectivity.
All synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable synthesis path should be selected according to the comprehensive consideration of factors such as the availability of raw materials, the difficulty of controlling reaction conditions, and the requirements of product purity.

2-Bromo-5- (4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl) pyridine, which is an extremely important compound in the field of organic synthesis. Its physical and chemical properties are unique and play a key role in the process of organic synthesis.
Looking at its physical properties, under normal temperature and pressure, this substance is often in a solid state, but its specific melting point, boiling point and other parameters vary depending on different preparation methods and conditions. Generally speaking, the melting point falls roughly within a certain temperature range, which is closely related to the intermolecular forces and crystal structure. Its appearance is mostly white to off-white crystalline powder with pure color, reflecting its relatively regular structure.
When it comes to chemical properties, the bromine atom in this compound is quite active. Because of its good departure properties, bromine atoms are easily replaced by various nucleophilic reagents in many nucleophilic substitution reactions. For example, when reacted with nucleophilic reagents such as nitrogen, oxygen, and sulfur, novel carbon-heteroatom bonds can be formed, and then a series of derivatives with different structures can be formed. Furthermore, the 1,3,2-dioxoboron heterocyclopentane structure in the molecule with dimethyl substitution endows it with unique boron chemical properties. In transition metal-catalyzed coupling reactions, such as the Suzuki-Miyaura coupling reaction, this structure can react with substrates such as aryl halides to form carbon-carbon bonds, thus realizing the construction of complex organic molecules. This reaction condition is mild and highly selective, and it is widely used in drug synthesis, materials science and other fields. In addition, the compound is relatively stable to air and water, but under certain conditions, reactions such as hydrolysis may still occur, causing boron-oxygen bond breakage, which affects its reactivity and stability.

I don't know what the market price of 2 - Bromo - 5 - (4, 4, 5, 5 - tetramethyl - 1, 3, 2 - dioxaborolan - 2 - yl) pyridine is. However, if you want to know its price, you can go through various channels.
First, check it in detail on the chemical raw material trading platform. Such platforms gather many suppliers, and the prices are often clearly listed. You can review the quotations of each supplier one by one, and re-consider the product specifications, purity and other factors to indicate the price range.
Second, ask the chemical product distributor. They have been involved in this industry for a long time and are familiar with the market. Or you can call or email and ask them about the current price of this product. Different distributors have different quotations due to different channels and costs. It is advisable to ask a few more to obtain more accurate information.
Third, observe the chemical exhibition. If there is such a product in the exhibition, you can communicate directly with the exhibitors and inquire about its price. And at the exhibition, you can often observe the latest market trends and trends, which is also beneficial to understand the price background.
However, its price is also affected by many factors. Product purity is important, and the price of high purity must be higher than that of low. Market supply and demand is also critical. If demand is strong and supply is low, the price will rise; conversely, if supply exceeds demand, the price may drop. In addition, raw material costs, production process difficulties, transportation costs, etc., will cause price fluctuations. Therefore, in order to know the accurate price, it is necessary to comprehensively consider various factors and make a more accurate judgment through multi-party inquiries and comparisons.

2-Bromo-5- (4,4,5,5-tetramethyl-1,3,2-dioxoboran-amyl-2-yl) pyridine is an important reagent commonly used in organic synthesis. Its storage conditions are very important in terms of its stability and reactivity.
This compound should be stored in a dry and cool place. It is easy to cause adverse reactions such as hydrolysis in case of moisture, which damages its structure and activity. Therefore, it is necessary to avoid humid air and choose a dry storage environment. Cool conditions are also indispensable. High temperature can easily cause the thermal movement of molecules to intensify, or cause decomposition and deterioration. Generally speaking, the storage temperature should not exceed 25 ° C. < Br >
Furthermore, it should be stored in a closed container. In this way, it can prevent excessive contact with air and reduce side reactions such as oxidation. And the material of the container also needs to be considered, and it should be selected with stable chemical properties and no reaction with it, such as glass or specific plastic materials.
When storing, it needs to be separated from oxidants, acids and other substances. Due to its chemical properties, if it coexists with these substances, it may cause severe chemical reactions, resulting in safety accidents. At the same time, the storage area should be equipped with appropriate leakage emergency treatment equipment and protective supplies to ensure safety.
In summary, the storage of 2-bromo-5- (4,4,5,5-tetramethyl-1,3,2-dioxoboran-2-yl) pyridine requires strict adherence to the principles of dry, cool, airtight, and isolation from unsuitable substances to ensure its quality and safety.