2-bromo-4-methylpyridine

2-Bromo-4-methylpyridine is an organic compound with specific physical properties. It is usually liquid at room temperature, and it may be a clear colorless to pale yellow liquid. Because the molecule contains bromine atoms and methyl groups, it has a certain density, about 1.48 g/cm ³, and is heavier than water. If mixed with water, it will sink to the bottom.
The boiling point of this substance is about 215-217 ° C. At this temperature, 2-bromo-4-methylpyridine changes from liquid to gaseous state. The boiling point is high, due to the existence of various forces between molecules, such as van der Waals force and polarity. Its melting point is about -10 ° C, below this temperature, the compound solidifies into a solid state.
2-bromo-4-methylpyridine has a certain solubility. Because the pyridine ring has a certain polarity, and the bromine atom and methyl affect the molecular polarity, it has good solubility in polar organic solvents such as ethanol and acetone, and can be miscible with these solvents in any ratio; however, the solubility in water is limited, only slightly soluble, because the force between water molecules and the compound is not enough to overcome the intermolecular force of the compound.
In addition, the compound has a certain volatility. Although the volatility is not extremely strong, some molecules will still escape into the air at room temperature. Because of its volatility, it needs to be operated in a well-ventilated environment to prevent excessive vapor inhalation. And 2-bromo-4-methylpyridine has a certain odor, often described as a pungent, pyridine-like odor, which is detectable at low concentrations and pungent and uncomfortable at high concentrations.

2-Bromo-4-methylpyridine is an organic compound with unique chemical properties that are worth exploring.
This compound contains bromine atoms and methyl groups, which have a significant impact on its chemical properties. The bromine atom has strong electronegativity, resulting in the nucleophilic substitution activity of 2-bromo-4-methylpyridine. Under appropriate nucleophilic reagents and reaction conditions, bromine atoms can be replaced by nucleophilic groups. For example, when reacted with alkoxides, bromine atoms may be replaced by alkoxy groups to form ether compounds; when reacted with amines, nitrogen-containing substitution products can be formed. The electron cloud density of the pyridine ring can be increased, especially in the methyl ortho-and para-positions, which can change the activity of the electrophilic substitution reaction on the ring. Compared with pyridine, the electrophilic substitution reaction of 2-bromo-4-methylpyridine is more likely to occur in the methyl ortho-and para-positions. However, at the same time, due to the electron-absorbing induction effect of bromine atoms, the overall electrophilic substitution activity is also affected by bromine atoms, so its reactivity and selectivity need to be considered comprehensively.
In addition, the 2-bromo-4-methylpyridine cyclic nitrogen atom has a lone pair of electrons, which can be used as a base to react with acids to form salts; it can also be used as a ligand to coordinate with metal ions to form complexes, which may have potential applications in catalysis and other fields.
In redox reactions, 2-bromo-4-methylpyridine may participate in related reactions because it contains oxidizable or reductive functional groups. For example, under the action of appropriate oxidizing agents, methyl groups may be oxidized to higher oxidation groups such as carboxyl groups; under the action of reducing agents, bromine atoms may be reduced to form 4-methylpyridine.
To sum up, 2-bromo-4-methylpyridine has rich chemical properties due to the existence of bromine atoms and methyl groups, and may have wide application and research value in many fields such as organic synthesis, medicinal chemistry, and materials science.

2-Bromo-4-methylpyridine is a compound commonly used in organic synthesis. The common synthesis methods are as follows:
First, 4-methylpyridine is used as the starting material. 4-methylpyridine can be reacted with a brominating reagent, such as bromine (Br ²), under suitable reaction conditions. In general, suitable solvents, such as halogenated hydrocarbon solvents such as dichloromethane, need to be selected, and appropriate catalysts, such as iron powder (Fe) or iron tribromide (FeBr ²), need to be added. Under these conditions, bromine atoms will selectively replace hydrogen atoms at specific positions on the pyridine ring to generate 2-bromo-4-methylpyridine. The mechanism of this reaction is that the Lewis acid catalyst promotes the polarization of bromine molecules and enhances their electrophilicity, which in turn causes electrophilic substitution at positions with higher electron cloud density on the pyridine ring.
Second, it can be prepared by functional group conversion of compounds containing pyridine rings. For example, pyridine derivatives containing suitable substituents are prepared first, and then the functional groups at specific positions are converted into bromine atoms and methyl groups through a series of reactions. If the starting compound has a group that can be converted to methyl at the 4-position of the pyridine ring, such as an acyl group, it can be converted to methyl by reduction reaction; at the same time, if there are suitable leaving groups at the 2-position, such as hydroxyl groups, it can be replaced by bromine atoms by halogenation reaction. Commonly used halogenating reagents include phosphorus tribromide (PBr), etc. Under appropriate reaction conditions, the hydroxyl group is replaced by a bromine atom to eventually form the target product 2-bromo-4-methylpyridine.
Third, the method of metal-organic chemistry is used. React with an organometallic reagent containing a pyridine ring with a reagent containing bromine. For example, a lithium reagent or a magnesium reagent (Grignard reagent) of 4-methylpyridine can be prepared first, and then react with brominated reagents, such as bromomethane, at low temperature, anhydrous and protected by an inert gas. This reaction takes advantage of the strong nucleophilicity of organometallic reagents to undergo nucleophilic substitution with brominated reagents to construct the structure of 2-bromo-4-methylpyridine. During the reaction process, the reaction conditions must be strictly controlled to ensure the selectivity and yield of the reaction.

2-Bromo-4-methylpyridine is an organic compound with important applications in various fields.
In the field of medicinal chemistry, this compound has a significant effect. Due to the unique structure of pyridine ring and bromine and methyl, it has specific chemical activities and pharmacological properties. It can be used as a key intermediate for the synthesis of many biologically active drug molecules. For example, for some new drug development targeting specific disease targets, 2-bromo-4-methylpyridine can introduce specific functional groups through a series of chemical reactions to construct drug structures with high affinity for disease-related proteins or receptors, providing an important starting material for innovative drug creation. < Br >
In the field of materials science, it also has applications. Due to the influence of bromine atoms and methyl groups on the electron cloud distribution of the pyridine ring, this compound can participate in the preparation of materials with special photoelectric properties. For example, in the synthesis of organic Light Emitting Diode (OLED) materials, it is introduced as a structural unit to regulate the luminous efficiency, color and other properties of the material, which helps to develop new high-efficiency luminescent materials and improve the performance of OLED display technology.
In the field of pesticide chemistry, 2-bromo-4-methylpyridine also plays an important role. Its structural properties enable it to be derived from compounds with insecticidal, bactericidal or herbicidal activities. Through chemical modification, pesticides with high efficiency in controlling specific crop diseases and insect pests are created, and because of their unique structure, they may reduce the impact on the environment and improve the selectivity and safety of pesticides.
In the field of organic synthetic chemistry, 2-bromo-4-methylpyridine is an important synthetic building block. With the reactivity of pyridine rings and the susceptibility of bromine atoms to substitution reactions, chemists can use them to construct complex organic molecular structures. Through nucleophilic substitution, metal catalytic coupling and other reactions, different functional groups and carbon chains are connected to expand the structural diversity of organic molecules, providing a powerful tool for the development of organic synthetic chemistry.

2-Bromo-4-methylpyridine is an important raw material in organic chemistry, and it is widely used in medicine, pesticides, materials science and other fields. As for its market price, it is difficult to determine precisely, due to many factors, its price often fluctuates.
The first to bear the brunt, the market supply and demand situation has the greatest impact on its price. If the market demand for 2-bromo-4-methylpyridine surges at a certain time, and the supply is relatively short, the price will rise; conversely, if the supply exceeds the demand, the price will decline. This supply and demand situation is influenced by the development of downstream industries, such as the pharmaceutical industry developing new drugs, which increases the demand for it, or the pesticide industry innovation causes its dosage to change.
Furthermore, the production cost is also a key factor. The price of raw materials, the complexity of the production process, energy consumption, etc., are all related to the production cost. If the price of raw materials rises, or the production process requires high investment, the price of the product will also increase accordingly in order to ensure profits.
Regional differences should not be underestimated. Different regions, due to the level of economic development, logistics costs, tax policies, etc., have different selling prices. Economically developed areas, with strong consumption capacity and convenient logistics, or due to market competition, prices may have different performance; remote areas, high logistics costs, or higher prices.
In addition, the degree of market competition also affects prices. If there are many market participants and the competition is fierce, companies may attract customers with price advantages, resulting in lower prices; conversely, if the market is monopolistic, the price may be controlled by monopolies.
Overall, the market price of 2-bromo-4-methylpyridine fluctuates frequently. To know its exact price, it is necessary to pay attention to market dynamics in real time and consider various factors such as supply and demand, cost, geography and competition.