2-Bromo-4-methyl-3-nitropyridine

2-Bromo-4-methyl-3-nitropyridine is one of the organic compounds. Its chemical properties are unique and quite important.
First, the bromine atom in this compound has nucleophilic substitution activity. Because the bromine atom is a good leaving group, nucleophilic substitution reactions can occur in the presence of many nucleophilic reagents. For example, when interacting with nucleophilic reagents such as alkoxides and amines, the bromine atom will be replaced by the corresponding group, resulting in the formation of new pyridine derivatives. This reaction mechanism usually follows the general formula of nucleophilic substitution. Nucleophilic reagents attack bromine-containing carbon atoms and bromine ions leave.
Furthermore, the presence of nitro groups also gives the compound special chemical properties. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the pyridine ring, making the pyridine ring more prone to electrophilic substitution reaction, and the substitution check point is mostly in the nitro interposition. At the same time, nitro can be reduced to amino groups under specific reduction conditions, and this process involves electron transfer and chemical bond breaking and recombination. Commonly used reducing agents include iron, hydrochloric acid, lithium aluminum hydride, etc., which can gradually reduce nitro to amino groups, and then obtain amino-containing pyridine derivatives. This derivative is widely used in drug synthesis, materials science and other fields.
In addition, although the 4-position methyl group is relatively stable, under strong oxidation conditions, methyl groups can be oxidized to other functional groups such as carboxyl groups. For example, when treated with strong oxidants such as potassium permanganate, methyl groups may be oxidized, thereby altering the chemical properties and reactivity of the entire molecule.
2-Bromo-4-methyl-3-nitropyridine, with its bromine atom, nitro and methyl properties, can be used as a key intermediate in the field of organic synthesis. Through various chemical reactions, organic compounds with diverse structures can be constructed, laying the foundation for drug research and development, material creation and many other fields.

The common synthesis methods of 2-bromo-4-methyl-3-nitropyridine are often studied in the field of organic synthetic chemistry. There are several common ways to synthesize this compound.
First, pyridine is used as the starting material. First, pyridine is nitrified. Under appropriate conditions, pyridine is treated with a mixed acid system of nitric acid and sulfuric acid, and nitro groups can be introduced into the pyridine ring. Due to the electron cloud distribution characteristics of the pyridine ring, nitro groups tend to be introduced at specific positions. This step requires precise control of the reaction conditions, such as temperature and reactant ratio, to obtain the desired 3-nitropyridine. Then, 3-nitropyridine is brominated, usually with brominating reagents such as N-bromosuccinimide (NBS), in the presence of appropriate solvents and initiators, to achieve bromination at the 2-position, and then to obtain 2-bromo-3-nitropyridine. Finally, through methylation, suitable methylating reagents are selected, such as methyl negative ions produced by the interaction of iodomethane and strong bases, and 2-bromo-3-nitropyridine is reacted with 2-bromo-3-nitropyridine to introduce methyl at the 4-position, and then the target product 2-bromo-4-methyl-3-nitropyridine is obtained.
Second, 4-methylpyridine can also be used as the starting material. First, 4-methylpyridine is nitrified, similar to the above conditions, nitro is introduced to obtain 3-nitro-4-methylpyridine. After that, the bromination step is carried out, and a suitable brominating agent is selected to introduce bromine atoms at the 2-position to synthesize 2-bromo-4-methyl-3-nitropyridine.
Each synthetic method has its own advantages and disadvantages. In actual operation, the choice needs to be weighed according to many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, the requirements of yield and purity, etc., in order to achieve the purpose of efficient and high-quality synthesis of 2-bromo-4-methyl-3-nitropyridine.

2-Bromo-4-methyl-3-nitropyridine is a very useful compound in organic synthesis. In the field of medicinal chemistry, it has a wide range of applications. The structural properties of this compound make it a key intermediate for the preparation of a variety of biologically active drug molecules. When developing antibacterial drugs, its unique substituent arrangement can be used to construct structures with high affinity to key bacterial targets through specific chemical reactions to achieve antibacterial effect.
It also has its uses in the field of materials science. Because its structure contains specific functional groups, it can be chemically modified into polymer materials, thereby giving the materials unique electrical, optical or thermal properties. For example, materials with special photoelectric conversion properties can be prepared for use in solar cells and other devices, which is expected to improve their energy conversion efficiency.
Furthermore, in the field of pesticide chemistry, 2-bromo-4-methyl-3-nitropyridine can also be an important synthetic building block. By chemically modifying it, new pesticides with high efficacy against specific pests and low impact on the environment and non-target organisms can be created, providing new strategies for agricultural pest control.
In conclusion, 2-bromo-4-methyl-3-nitropyridine has important applications in many fields such as medicine, materials, and pesticides due to its unique chemical structure, providing strong support for the development of related fields.

2-Bromo-4-methyl-3-nitropyridine is one of the organic compounds. Its physical properties are quite unique, let me tell you in detail.
Looking at its properties, at room temperature, this compound is mostly in a solid state. As for its color, it is usually a white-like to light yellow powder or crystal. The formation of this color is related to the arrangement of atoms in its molecular structure and the distribution of electron clouds.
When it comes to melting point, the melting point of 2-bromo-4-methyl-3-nitropyridine is within a specific range, and this value is crucial for the identification and purification of this substance. The determination of the melting point can provide a strong basis for judging its purity. If impurities are mixed, the melting point often changes.
Furthermore, its solubility is also an important physical property. In common organic solvents, such as dichloromethane, chloroform, etc., 2-bromo-4-methyl-3-nitropyridine exhibits some solubility, but in water, its solubility is quite limited. This difference in solubility is due to the polar characteristics of its molecules. In the molecular structure, functional groups such as bromine and nitro give it a certain polarity, but due to the existence of pyridine rings and methyl groups, the overall polarity is not very high. Therefore, the solubility of polar solvent water and non-polar or weakly polar organic solvents is significantly different.
In addition, the density of the compound is also one of the inherent physical properties. Its density is closely related to the type and quantity of atoms and the way molecules are deposited. Although the specific value needs to be determined by precise experiments, this property is of great significance in practical application scenarios such as chemical production, separation and purification, and is related to material ratio, phase separation, and many other links.
In summary, the physical properties of 2-bromo-4-methyl-3-nitropyridine, from appearance, melting point, solubility to density, play a pivotal role in its application in organic synthesis, drug development, and other fields. When researchers and practitioners use it, they cannot ignore it.

I don't know what the market price of 2 - Bromo - 4 - methyl - 3 - nitropyridine is. The price of this compound often varies due to multiple factors and is difficult to determine.
First, purity is the key factor. If its purity is extremely high and almost perfect, it is suitable for high-end scientific research experiments, fine chemical synthesis and other fields, and the price will be high. The preparation of high-purity substances requires exquisite craftsmanship and strict processes, and the cost will be high. If the purity is slightly lower, it can only be used for general industrial purposes, and the price should be relatively low.
Second, market supply and demand also determine its price. If many scientific research institutions and chemical companies have strong demand for this material, but the supply is limited, just like there are few porridge monks and many monks, the price will rise. On the contrary, if the demand is weak and the supply is sufficient, just like there are many goods and few customers, the price will easily fall.
Third, the difficulty of preparation has a great impact. If the synthesis of this compound requires complex steps, rare raw materials, and special reaction conditions, the cost will increase greatly, and the price will also rise. If the preparation is relatively simple, the cost is controllable, and the price will tend to be easy.
Fourth, sales channels and purchase volume also play a role. Purchased by regular large-scale reagent suppliers, although the quality is guaranteed, the price may be high; if purchased through special channels or in large quantities, preferential prices may be available. Therefore, in order to know the exact market price of 2 - Bromo - 4 - methyl - 3 - nitropyridine, it is necessary to carefully investigate its purity, consult multiple suppliers, and consider many factors such as current market supply and demand and purchase volume. Only by comprehensively weighing can a more accurate price be obtained.