2-Bromo-4-(hydroxymethyl)pyridine

2-Bromo-4- (hydroxymethyl) pyridine is one of the organic compounds. Its physical properties are quite worthy of investigation.
Looking at its properties, at room temperature, this substance is mostly in a solid state. As for the color, or white to off-white powder, this is due to the characteristics of its structure and molecular arrangement. The shape of the powder is due to the interaction between molecules, which causes it to aggregate under normal conditions.
When it comes to the melting point, it is within a certain range, which is determined by the strength of the intermolecular force. The interaction between bromine atoms in the molecule and pyridine rings and hydroxymethyl groups allows the molecules to be arranged in an orderly manner. A specific energy is required to break this order, and the melting point is in a specific numerical range.
Solubility is also an important physical property. In water, because it contains hydroxymethyl, this group is hydrophilic, so it has a certain solubility. However, the pyridine ring and the bromine atom have a certain hydrophobicity, so it is not very soluble in water. In organic solvents such as ethanol and dichloromethane, its solubility is better due to the principle of similar miscibility. The hydroxyl group of ethanol and the hydroxymethyl group of the compound can form hydrogen bonds, which is conducive to its dissolution; the non-polar part of dichloromethane interacts with the electron cloud around the pyridine ring and the bromine atom, which also promotes dissolution.
In addition, its density is also characterized. Due to the large relative atomic weight of the bromine atom in the molecule, its density is higher than that of some common organic compounds, and the molecule is tightly packed, which increases the unit volume mass
In summary, the physical properties of 2-bromo-4- (hydroxymethyl) pyridine, such as its properties, melting point, solubility, density, etc., are determined by its unique molecular structure, which is of great value in its synthesis, separation, and application.

The synthesis method of 2-bromo-4- (hydroxymethyl) pyridine, although the ancient book "Tiangongkai" does not directly describe the synthesis method of this specific compound, it can be deduced by its chemical process idea.
First, the compound containing the pyridine ring can be used as the starting material. If 4-methyl pyridine is found, the bromination reaction can be used first to obtain 2-bromo-4-methyl pyridine with a suitable brominating agent, such as liquid bromine, under the catalysis of a suitable catalyst (such as iron powder), the bromine atom is substituted for the hydrogen of the 4-methyl pyridine methyl ortho position to obtain 2-bromo-4-methyl pyridine. Then, the product is moderately oxidized with a mild oxidizing agent, such as a mixed system of manganese dioxide and sulfuric acid, to convert the methyl to hydroxymethyl, and 2-bromo-4- (hydroxymethyl) pyridine can be obtained.
Second, if 2-bromopyridine is used as the starting material, metal-organic reagents, such as n-butyllithium, can be used to react with 2-bromopyridine at low temperature to lithium the pyridine ring at a specific position, and then react with formaldehyde to introduce hydroxymethyl. After subsequent treatment, 2-bromopyridine can also be obtained.
Third, you can also consider using pyridine-4-formaldehyde as a raw material to protect the aldehyde group first to prevent it from being affected during bromination. After protecting with acetal formed by ethylene glycol and aldehyde group, brominate with a brominating agent, then hydrolyze the acetal under acidic conditions to restore the aldehyde group, and finally reduce the aldehyde group to hydroxymethyl group with a suitable reducing agent, such as sodium borohydride, to obtain the target product 2-bromo-4- (hydroxymethyl) pyridine. This is based on the basic principles of chemistry and the synthesis of similar compounds, hoping to provide some ideas for the synthesis of this compound.

2-Bromo-4- (hydroxymethyl) pyridine, which is wonderfully useful in many fields. In the field of pharmaceutical creation, it can be a key synthetic building block. The characteristics of the Gainpyridine ring and bromine and hydroxymethyl groups can be used for chemical synthesis to build complex drug molecules, which is of great value for the development of new drugs and the treatment of various diseases.
In the field of materials science, it also has its uses. Its hydroxymethyl group can participate in specific polymerization reactions and cross-link with other monomers to create polymer materials with specific properties. Or it has unique mechanical properties and thermal stability, and can be used as an important raw material in the manufacture of high-end materials.
In the field of organic synthetic chemistry, as a reaction substrate, it has a wide range of uses. Bromine atoms are active and can introduce other functional groups through reactions such as nucleophilic substitution to expand the structural diversity of molecules. Hydroxymethyl can also participate in reactions such as oxidation and esterification, providing many possibilities for the synthesis of complex organic compounds and assisting organic chemists to construct various novel molecular structures. From this perspective, 2-bromo-4- (hydroxymethyl) pyridine plays an indispensable role in the fields of medicine, materials, and organic synthesis, promoting the sustainable development and innovation of various fields.

2-Bromo-4- (hydroxymethyl) pyridine is also a chemical substance. The key to its storage is related to the quality and use of this substance, and it should not be careless.
The first thing to store is the temperature and humidity of the environment. It should be placed in a cool place, away from direct sunlight. Sunlight can promote its chemical reactions, causing it to decompose or deteriorate. As for the temperature, it is better not to be higher than 25 degrees Celsius. If it is too high, the molecular movement will intensify and it will be prone to changes. Humidity must also be controlled. If the humidity is too high, water vapor will easily attach to it, or cause reactions such as hydrolysis.
Furthermore, the storage must be dry and ventilated. If it is dry, there will be no water vapor. Ventilation can remove harmful gas and prevent it from accumulating and causing harm. And this material should be isolated from oxidants, acids, etc. Oxidants have strong oxidizing properties and may react violently when exposed; acids can also interact with it and damage its quality.
Also, the storage container is also particular. A sealed container must be used to prevent it from coming into contact with air. Glass or plastic utensils can be selected if the material is suitable. However, it is necessary to check whether they are compatible with the object and do not react.
When handling, it should also be handled with care to prevent it from being damaged by earthquakes. If the container is damaged, this object will be exposed and dangerous. In conclusion, store 2-bromo-4- (hydroxymethyl) pyridine under all conditions to preserve its quality for later use.

I don't know what the market price of 2 - Bromo - 4 - (hydroxymethyl) pyridine is. However, if you want to know its price, you can explore it in many ways.
In the world of "Tiangong Kaiwu", the price of a product often varies depending on the place of origin, supply and demand, and age. The same is true of today's 2 - Bromo - 4 - (hydroxymethyl) pyridine. First, you can consult traders of chemical raw materials. This generation is often involved in the sale of this product and is familiar with the ups and downs of its price. Traders in different places may quote different prices due to different regions and channels. Second, the chemical product trading platform can also be a way to explore prices. This kind of platform gathers a lot of buying and selling information, and can compare the prices quoted by different sellers to see the price range. Third, refer to relevant industry reports, which may include the analysis of the market price trend of this product and the current approximate price.
However, the price changes rapidly, which is influenced by many factors such as raw material costs, production process improvements, policies and regulations, and international situations. If the price of raw materials rises, or production encounters difficulties, the price may rise; if new processes are introduced, production capacity increases greatly, or demand decreases sharply, the price may fall. Therefore, in order to know the real-time and accurate market price, it is necessary to inquire through multiple channels and pay attention to it often to respond to changes.