2-bromo-4-cyanopyridine

2-Bromo-4-cyanopyridine is also an important compound in organic synthesis. Its main uses are multi-terminal, and it is often a key intermediate in the field of medicinal chemistry. When covering the creation of medicine, it is necessary to build a specific chemical structure. 2-Bromo-4-cyanopyridine can introduce other functional groups through various chemical reactions, such as nucleophilic substitution and cyano groups, to build a complex molecular structure that meets pharmacological requirements, and to help the development of new drugs.
In the field of materials science, it also has important functions. Through appropriate chemical reactions, it can be integrated into polymer materials or functional materials. Due to its special structure, it may endow materials with unique electrical, optical or mechanical properties, such as for the preparation of organic semiconductor materials with specific optoelectronic properties, which contributes to the development of organic electronic devices.
Furthermore, in the field of pesticide chemistry, it is also indispensable. Using it as a starting material and through series transformation, a variety of pesticide products with high-efficiency insecticidal, bactericidal or herbicidal activities can be created. Using its chemical activity, effective molecules that interact with pests and pathogens can be constructed, providing a powerful means for pest control in agricultural production.
In conclusion, 2-bromo-4-cyanopyridine plays a key role in many fields such as medicine, materials, and pesticides, and provides important support for the development of various fields due to its unique chemical structure and reactivity.

The synthesis method of 2-bromo-4-cyanopyridine has been known in ancient times, and the routes are different. Today, it is detailed by you.
One of them can be started from 4-cyanopyridine. The cyanyl group of 4-cyanopyridine is active and can be substituted with brominating reagents. Commonly used brominating reagents, such as bromine (Br ²), can replace the 2-position hydrogen atom of 4-cyanopyridine with a bromine atom under appropriate reaction conditions, resulting in 2-bromo-4-cyanopyridine. However, for this reaction, it is necessary to choose a suitable solvent, such as dichloromethane and other inert organic solvents, to ensure the smooth progress of the reaction. And the reaction temperature, time and other conditions also need to be carefully regulated. If the temperature is too high, there may be a risk of excessive bromination; if the temperature is too low, the reaction rate will be slow and take a long time. When reacting, it is also necessary to pay attention to the amount of bromine. If the amount is too small, the reaction will not be complete; if the amount is too much, not only will the reagent be wasted, but also impurities may be introduced.
Second, the pyridine derivative can be started. First, a suitable substituent is introduced into the pyridine ring to construct a suitable intermediate, and then a cyano group and bromine atom are gradually introduced through a multi-step reaction For example, pyridine can be used as a raw material, and a group that can be converted into a cyanyl group, such as a halogen atom, can be introduced at the 4-position of the pyridine ring through a Friedel-Crafts reaction. Then, through a nucleophilic substitution reaction, the halogen atom is replaced with a cyanyl negative ion to obtain a 4-cyanopyridine derivative. After a bromination reaction, a bromine atom is introduced at the 2-position to obtain 2-bromo-4-cyanopyridine. Although this route is slightly complicated, the order and position of the substituents on the pyridine ring can be precisely regulated, which is conducive to improving the purity and yield of the product.
Third, there are also methods of metal catalysis. Metal-containing catalysts, such as palladium catalysts, are used to catalyze the coupling reaction between specific substrates. Suitable halogenated pyridine derivatives and cyanogen-containing reagents can be selected. Under the action of palladium catalysts and ligands, a cyanation reaction occurs, and a cyanyl group is introduced at the 4-position of the pyridine ring. Subsequently, a bromination reaction can be carried out to obtain the target product. This method relies on high-efficiency metal catalysts, and requires a high purity of the reaction system. Trace impurities may affect the activity of the catalyst, which in turn affects the progress of the reaction. However, its advantages are that the reaction conditions are relatively mild, environmentally friendly, and the product selectivity is good, which is expected to play an important role in large-scale production.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to choose carefully according to the availability of raw materials, cost, operability of reaction conditions, and requirements for product purity and yield, etc., in order to achieve the purpose of efficient synthesis of 2-bromo-4-cyanopyridine.

2-Bromo-4-cyanopyridine is an organic compound, and its physical properties are worthy of investigation. This substance is usually solid at room temperature, and its appearance is mostly white to light yellow crystalline powder with fine texture. Its melting point is between 125-128 ° C, which makes it undergo physical state transformation under specific temperature conditions, providing an important reference for related operations and applications.
From the perspective of solubility, 2-bromo-4-cyanopyridine has good solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. In dichloromethane, it can disperse and dissolve relatively quickly to form a homogeneous solution, which is attributed to the adaptation of the forces between the two molecules. However, it has little solubility in water. Due to the bromine atom, cyano group and pyridine ring structure contained in its molecular structure, it is difficult to form effective interactions with water molecules, making it difficult to dissolve in water.
The density of this compound is about 1.66 g/cm ³. This density value determines its floating condition in a liquid system and is of great significance in operations involving liquid-solid separation or mixed systems. In terms of stability, it is relatively stable under conventional conditions, but when it encounters strong oxidizing agents, strong acids or strong bases, chemical reactions may occur and structural changes may occur. During storage and use, it is necessary to avoid contact with such substances, usually in a cool, dry and well-ventilated place to ensure the stability of their physical properties and chemical structures.

2-Bromo-4-cyanopyridine is an organic compound with many unique chemical properties. Its molecules contain bromine atoms, cyano groups and pyridine rings, which give it a variety of reactivity.
As far as nucleophilic substitution is concerned, bromine atoms are easily replaced by nucleophiles due to their good departure properties. In case of hydroxyl negative ions, bromine atoms can be replaced by hydroxyl groups to generate 2-hydroxy-4-cyanopyridine. This reaction is more likely to occur under alkaline conditions, and bases can assist nucleophiles in attacking and accelerating the reaction process.
Cyanos are also active groups and can participate in a variety of reactions. If it can be hydrolyzed under acidic or basic conditions, it can be converted into carboxyl groups when acidic to generate 2-bromo-4-pyridinecarboxylic acid; when basic, amide intermediates are first generated, and then further hydrolyzed to carboxylic acids. Cyanyl groups can also be added to compounds containing active hydrogen, such as imide ether intermediates with alcohols under alkali catalysis, which are then converted into amide derivatives. The presence of the
pyridine ring makes the compound have a certain alkalinity. The nitrogen atom of the pyridine can accept protons and react with strong acids to form salts. This basic property affects its solubility and reactivity in different solvents. In some organic synthesis, this alkalinity can be used to control the reaction direction and rate by adjusting the pH of the reaction system.
2-bromo-4-cyanopyridine exhibits rich chemical properties due to the interaction of bromine atom, cyano group and pyridine ring, providing many possibilities for organic synthetic chemistry, and has important application potential in medicinal chemistry, materials science and other fields.

It is difficult to determine the price range of 2-bromo-4-cyanopyridine in the market. The price of the cover often varies due to various reasons.
In terms of production sources, if the origin is wide and the output is abundant, the price may be more affordable; if the production source is narrow and the production is small, the price will be more expensive. In addition, the demand of the market is also the main reason. If there are many people who want it, the supply will exceed the demand, and the price will rise; if there is a shortage of goods, the price should be reduced.
Furthermore, the cost of production is also related to the price. The price of raw materials, the simplicity of the manufacturing process, and the cost of labor can all make the price different. If the price of raw materials is high, the manufacturing process is complicated, and the labor is expensive, the price of the finished product must be high; otherwise, the price may be low.
Today in the market, the price of 2-bromo-4-cyanopyridine ranges from a few yuan to a few tens of yuan per gram. If you buy a small quantity, the price may be higher; if you buy a large quantity, you may reduce the price slightly to facilitate the transaction. However, this is only a rough estimate. The actual price still needs to be consulted with drug dealers, chemical material vendors or relevant trading platforms to determine the exact number.