2-Bromo-4-cyanopyridine;2-Bromoisoniconinonitrile

2-Bromo-4-cyanopyridine (2-Bromo-4-cyanopyridine), also known as 2-bromo-isonicotinitrile (2-Bromoisoniconinonitrile), is an organic compound with unique chemical properties.
It has a double activity check point of halopyridine and cyano. The halogen atom has high activity of bromine and can participate in nucleophilic substitution reactions. Under the action of alkali, nucleophiles such as alkoxides and amines can attack the carbon atoms attached to the bromine atom, and the bromine ions leave to form new carbon-heteroatom bond compounds. Ether products can be obtained by reacting with sodium alcohol; when reacting with ammonia or amines, the corresponding amino substitution products are generated. This reaction is of great significance for the preparation of nitrogen-containing heterocyclic derivatives in organic synthesis.
Cyanyl groups are active and can undergo a variety of reactions. Cyanyl hydrolysis, under acidic or basic conditions, forms amides and then hydrolyzes into carboxylic acids; cyanyl groups can also react with Grignard reagents, through nucleophilic addition and rehydrolysis, ketones can be obtained, providing an effective way to construct complex organic structures.
The conjugated system of 2-bromo-4-cyanopyridine makes its electron cloud distribution special, which affects its reactivity and physical properties. The conjugated structure makes its stability different from that of ordinary saturated compounds, and affects the spectral properties of the compounds. For example, there are characteristic absorption peaks in the ultraviolet-visible spectrum, which provides a basis for qualitative and quantitative analysis.
In addition, the compound has a certain polarity due to the presence of bromine and cyanyl groups, which affects its solubility in different solvents. It has better solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), but poor solubility in non-polar solvents. This property needs to be taken into account in the separation, purification and reaction system selection of compounds.

The synthesis of 2-bromo-4-cyanopyridine (2-bromo-4-cyanopyridine) and 2-bromo-isonicotinitrile (2-Bromoisoniconinonitrile, Note: This English expression is wrong, it should be 2-Bromoisonicotinonitrile), which is an important topic in organic synthetic chemistry.
In the past, the synthesis of these two often followed the following path. Using pyridine as the initial raw material, the pyridine ring has a unique electron cloud distribution, which lays the foundation for the subsequent reaction. First, brominated reagents react with it to obtain brominated pyridine derivatives. Commonly used brominating reagents, such as liquid bromine and iron powder catalytic system, this system uses iron powder and bromine to form iron bromide, and iron bromide catalyzes the reaction of bromine and pyridine, introducing bromine atoms at specific positions in the pyridine ring to form bromine-containing pyridine intermediates.
After obtaining bromine-containing pyridine intermediates, cyanide reagents are often used to introduce cyanide groups. Conventional cyanide reagents such as potassium cyanide react with bromine-containing pyridine intermediates in a suitable organic solvent under base catalysis. Nucleophilic substitution reaction occurs. In this reaction, the cyanide negative ion as a nucleophilic agent attacks the check point of bromine atom connection of bromine-containing pyridine intermediates, and the bromine ion leaves, thus successfully introducing the cyanyl group to generate 2-bromo-4-cyanopyridine.
Another synthesis strategy is to use 4-cyanopyridine as the starting material and brominate it first, and the target product can also be obtained. Selecting the appropriate brominating agent and reaction conditions can realize the substitution of bromine atoms at the designated position of the pyridine ring, so as to achieve the synthesis of 2-bromo-4-cyanopyridine. < Br >
When synthesizing 2-bromo isonicotinitrile, the isonicotinitrile-related derivatives can be prepared first, and then the bromination step can be carried out. With isonicotinic acid as the raw material, the isonicotinitrile derivative is appropriately converted, and then the bromine atom is introduced at the appropriate position through the bromination reaction to complete the synthesis of 2-bromo isonicotinitrile.
The fine regulation of the reaction conditions is crucial for the synthesis of these two. Factors such as temperature, reaction time, and the proportion of reactants all have a profound impact on the reaction yield and selectivity. Only by accurately controlling each factor can the synthesis of the target product

2-Bromo-4-cyanopyridine (2-Bromo-4-cyanopyridine) and 2-bromo-isonicotinitrile (2-Bromoisoniconinonitrile, this name may be wrong, it is speculated that 2-bromo-isonicotinitrile should be 2-Bromoisonicotinonitrile) are used in various fields.
In the field of medicinal chemistry, it is a key organic synthesis intermediate. It can be converted into biologically active compounds by chemical reactions. For example, using this as a starting material, drug molecules with specific structures can be constructed to work against specific disease targets. For example, when developing new antibacterial drugs, their special structures are used to bind to specific proteins in bacteria, interfering with the normal physiological activities of bacteria, and achieving antibacterial effect.
In the field of materials science, such compounds can participate in the preparation of functional materials. Due to the characteristics of bromine and cyanyl groups in the molecular structure, they can be introduced into the main chain or side chain of polymer materials through polymerization or modification reactions, giving the materials unique properties, such as changing the optical properties, electrical properties or thermal stability of the materials. For example, when preparing organic optoelectronic materials, adding such compounds may improve the absorption and conversion efficiency of light by the materials, and be used to fabricate better Light Emitting Diodes or solar cells.
In the field of organic synthetic chemistry, it is an important synthetic building block. With the active reactivity of bromine atoms and cyanyl groups, many reactions such as nucleophilic substitution and electrophilic addition can occur to construct complex organic molecular structures. Chemists can use 2-bromo-4-cyanopyridine or 2-bromo isonitrile to construct organic compounds with special spatial configurations and functional groups by carefully designing reaction routes, which contribute to the development of organic synthetic chemistry.

I am inquiring about the market prices of 2-bromo-4-cyanopyridine (2-bromo-4-cyanopyridine) and 2-bromo-isonicotinitrile (2-Bromoisoniconinonitrile). However, the prices of the two are often changed due to various reasons, and it is difficult to determine a certain number.
First, the price of raw materials has a great impact on it. If the raw materials required to synthesize the two are abundant and affordable, the cost of the product will be low, and the price will not be high; conversely, if the raw materials are scarce and expensive, the price of the finished product will rise.
Second, market supply and demand are also key. If the market demand for the two is strong and the output is limited, the merchant will raise the price to sell; if the demand is low and the supply is excessive, the price will decline.
Third, the origin and quality also affect the price. Different origins have different prices due to differences in production processes and costs; those with better quality often have higher prices than ordinary ones.
According to past market conditions, the prices of the two may fluctuate between tens of yuan and hundreds of yuan per kilogram. However, the market is changing rapidly. To know the exact price, you should consult chemical raw material suppliers, chemical trading platforms, or related industry people to get the current accurate price.

2-Bromo-4-cyanopyridine (2-Bromo-4-cyanopyridine) and 2-bromo-isonicotinitrile (2-Bromoisoniconinonitrile) refer to the same substance. This medicine should be placed in a cool, dry and well-ventilated place, away from open flames and hot topics. Because of its chemical activity, it is necessary to keep away from strong oxidants, strong acids, strong bases and other substances to prevent violent reactions from causing safety hazards.
When storing, use a sealed container to prevent it from contacting with air and moisture. Water vapor in the air may cause it to hydrolyze, which affects the quality and purity. And it should be stored separately from food and feed to prevent the risk of accidental ingestion.
Warehouse management also needs to be strict, and a special person is responsible for establishing detailed warehousing records. Regularly check the storage status. If the packaging is damaged or the drug properties change, deal with it in time. Be careful during handling to avoid packaging damage caused by collision and dumping. Follow the above storage conditions to ensure the quality and stability of 2-bromo-4-cyanopyridine (2-Bromoisoniconinonitrile) and reduce safety risks.